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您的检索式：作者名="Wagner N.Mussel"
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| 1 | Physicochemical characterization, the Hirshfeld surface, and biological evaluation of two meloxicam compounding pharmacy samples显示文摘Meloxicam(MLX) is an anti-inflammatory drug susceptible to variations and crystalline transitions. In compounding pharmacies, the complete crystallographic evaluation of the raw material is not a routine procedure. We performed a complete crystallographic characterization of aleatory raw MLX samples from compounding pharmacies. X-ray diffraction indicated the presence of two crystalline forms in one sample. DSC experiments suggested that crystallization, or a crystal transition, occurred differently between samples. The FTIR and ~1H NMR spectra showed characteristic assignments.^(13)C solid-state NMR spectroscopy indicated the presence of more than one phase in a sample from pharmacy B. The Hirshfeld surface analysis, with electrostatic potential projection, allowed complete assignment of the UV spectra in ethanol solution. The polymorph I of meloxicam was more active than polymorph III in an experimental model of acute inflammation in mice. Our results highlighted the need for complete crystallographic characterization and the separation of freely used raw materials in compounding pharmacies,as a routine procedure, to ensure the desired dose/effect. | Luciana F.A.Romani Maria I.Yoshida Elionai C.L.Gomes Renes R.Machado Felipe F.Rodrigues Marcio M.Coelho Marcelo A.Oliveira Maria B.Freitas-Marques Rosane A.S.San Gil Wagner N.Mussel | 2018 | Journal of Pharmaceutical Analysis2018，8，2： | 0 |
| 2 | Physics, chemistry, and Hirshfeld surface analyses of gamma-irradiated thalidomide to evaluate behavior under sterilization doses显示文摘Thalidomide was indicated as a sedative and antiemetic and prescribed for pregnant women. Its tragic teratogenic effects culminated in withdrawal from the market. Since the discovery of its anti-angiogenic and anti-inflammatory actions, thalidomide has been used in the treatment of leprosy and multiple myeloma,which justify studies of its stability. We investigated the effects of irradiation of thalidomide up to 100 k Gy(fourfold the usual sterilizing dose for pharmaceutics). The β polymorph of thalidomide was obtained in an isothermal experiment at 270 °C. All samples underwent gamma irradiation for specific times. At different doses, decomposition of the pharmaceutical was not observed up to 100 k Gy. The observed effect was angle turning between the phthalimide and glutarimide rings modulated by repulsion towards the carbonyl group,leading to a stable energetic configuration, as measured by the equilibrium in the torsion angle after irradiation. The thalidomide molecule has a center of symmetry, so a full turn starting from 57.3° will lead to an identical molecule. Further irradiation will start the process again. Samples irradiated at 30 and 100 k Gy have more compact unit cells and a lower volume, which leads to an increase in the intermolecular hydrogen interaction within the unit cell, resulting in higher thermal stability for polymorph α. | Valner A.F.S.N.Mussel Max R Ferreira Maria B.E Marques Maria I.Yoshida Mariana R.Almeida Bernardo L.Rodrigues Wagner N.Mussel | 2018 | Journal of Pharmaceutical Analysis2018，8，3： | 0 |
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