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您的检索式：作者名="Valner A.F.S.N.Mussel"
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| 1 | Physics, chemistry, and Hirshfeld surface analyses of gamma-irradiated thalidomide to evaluate behavior under sterilization doses显示文摘Thalidomide was indicated as a sedative and antiemetic and prescribed for pregnant women. Its tragic teratogenic effects culminated in withdrawal from the market. Since the discovery of its anti-angiogenic and anti-inflammatory actions, thalidomide has been used in the treatment of leprosy and multiple myeloma,which justify studies of its stability. We investigated the effects of irradiation of thalidomide up to 100 k Gy(fourfold the usual sterilizing dose for pharmaceutics). The β polymorph of thalidomide was obtained in an isothermal experiment at 270 °C. All samples underwent gamma irradiation for specific times. At different doses, decomposition of the pharmaceutical was not observed up to 100 k Gy. The observed effect was angle turning between the phthalimide and glutarimide rings modulated by repulsion towards the carbonyl group,leading to a stable energetic configuration, as measured by the equilibrium in the torsion angle after irradiation. The thalidomide molecule has a center of symmetry, so a full turn starting from 57.3° will lead to an identical molecule. Further irradiation will start the process again. Samples irradiated at 30 and 100 k Gy have more compact unit cells and a lower volume, which leads to an increase in the intermolecular hydrogen interaction within the unit cell, resulting in higher thermal stability for polymorph α. | Valner A.F.S.N.Mussel Max R Ferreira Maria B.E Marques Maria I.Yoshida Mariana R.Almeida Bernardo L.Rodrigues Wagner N.Mussel | 2018 | Journal of Pharmaceutical Analysis2018，8，3： | 0 |
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