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| 1 | Shifting equilibriums in Alzheimer’s disease: the complex roles of microglia in neuroinflammation, neuronal survival and neurogenesis显示文摘Alzheimer's disease is the leading cause of dementia.Its increased prevalence in developed countries,due to the sharp rise in ageing populations,presents one of the costliest challenges to modern medicine.In order to find disease-modifying therapies to confront this challenge,a more complete understanding of the pathogenesis of Alzheimer's disease is necessary.Recent studies have revealed increasing evidence for the roles played by microglia,the resident innate immune system cells of the brain.Reflecting the well-established roles of microglia in reacting to pathogens and inflammatory stimuli,there is now a growing literature describing both protective and detrimental effects for individual cytokines and chemokines produced by microglia in Alzheimer's disease.A smaller but increasing number of studies have also addressed the divergent roles played by microglial neurotrophic and neurogenic factors,and how their perturbation may play a key role in the pathogenesis of Alzheimer's disease.Here we review recent findings on the roles played by microglia in neuroinflammation,neuronal survival and neurogenesis in Alzheimer's disease.In each case,landmark studies have provided evidence for the divergent ways in which microglia can either promote neuronal function and survival,or perturb neuronal function,leading to cell death.In many cases,the secreted molecules of microglia can lead to divergent effects depending on the magnitude and context of microglial activation.This suggests that microglial functions must be maintained in a fine equilibrium,in order to support healthy neuronal function,and that the cellular microenvironment in the Alzheimer's disease brain disrupts this fine balance,leading to neurodegeneration.Thus,an understanding of microglial homeostasis,both in health and across the trajectory of the disease state,will improve our understanding of the pathogenic mechanisms underlying Alzheimer's disease,and will hopefully lead to the development of microglial-based therapeutic strategies to restore equilibrium in the Alzheimer's disease brain. | Sophie C. Gray Kerri J. Kinghorn Nathaniel S. Woodling | 2020 | Neural Regeneration Research2020，15，7： | 13 |
| 2 | 个体化免疫抑制疗法III:西罗莫司与恶性病变发生率降低有关显示文摘 | Yakupoglu YK Buell JF Woodle S Kahan BD | 2006 | 中国处方药2006，5，5： | 3 |
| 3 | Increasing prevalence of nonalcoholic steatohepatitis as an indication for liver transplantation显示文摘 | R. Cutler Quillin Gregory C. Wilson Jeffrey M. Sutton Dennis J. Hanseman Flavio Paterno Madison C. Cuffy Ian M. Paquette Tayyab S. Diwan E. Steve Woodle Daniel E. Abbott Shimul A. Shah | 2014 | Surgery2014，，4： | 2 |
| 4 | Bortezomib Provides Effective Therapy for Antibody- and Cell-Mediated Acute Rejection显示文摘 | Matthew J. Everly Jason J. Everly Brian Susskind Paul Brailey Lois J. Arend Rita R. Alloway Prabir Roy-Chaudhury Amit Govil Gautham Mogilishetty Adele H. Rike Michael Cardi George Wadih Amit Tevar E Steve Woodle | 2008 | Transplantation2008，，12： | 2 |
| 5 | Harnessing in vivo siRNA delivery for drug discovery and therapeutic development 显示文摘 | Xie FY Woodle MC Lu PY | 2006 | Drug Discov Today2006，11，12： | 1 |
| 6 | Tumor necrosis factor a-lpha can contribute to focal toss of cartitage in osteoarthritis显示文摘 | Westacott CI Barakat AF WoodL | 2000 | Osteoarthritis Cartilage2000，8，： | 1 |
| 7 | Resveratrol, a dietary polyphenolic phytoalexin, is a functional scavenger of peroxynitrite显示文摘 | Joseph H. Holthoff Kellie A. Woodling Daniel R. Doerge Samuel T. Burns Jack A. Hinson Philip R. Mayeux | 2010 | Biochemical Pharmacology2010，，8： | 1 |
| 8 | Resveratrol,a dietary polyphenolic phytoalexin,is a functional scavenger of peroxynitrite显示文摘 | Holthoff JH Woodling KA Doerge Dr | | 0，，08： | 1 |
| 9 | Modulation of angiogenesis with siRNA inhibitors for novel therapeutics显示文摘 | Lu PY Xie FY Woodle MC | 2005 | Trends Mol Med2005，11，3： | 1 |
| 10 | 显示文摘 | Kernochan LE Russo ML Woodling NS | 2005 | Hum Mol Genet2005，14，9： | 1 |
| 11 | Harnessing in vivo siRNA delivery for drug discovery and therapeutie development显示文摘 | XIE F Y WOODLE M C LU P Y | 2006 | Drug Discovery Today2006，11，： | 1 |
| 12 | Sterically stabilized liposomes显示文摘 | Lasic DD | 1992 | Biochim Biophys Acta1992，1113，2： | 1 |
| 13 | Tacrolimu s for primary treatment of steroid-resistant hepatic allograft rejection显示文摘 | Millis JM Woodle ES Piper JB | 1996 | T ransplantation1996，61，9： | 1 |
| 14 | Sterically stabilized liposomes显示文摘 | Woodle M C Lasic D D | 1992 | Biochim Biophys Acta1992，1113，： | 1 |
| 15 | A prospective,randomized,multicenter study evaluating early corticosteroid withdrawal with thymoglobulin in liv ingdonor kidney withdrawal with thymoglobulin in living donor kidney transplantation显示文摘 | Woodle ES Peddi VR Tomlanovich S | | 0，，1： | 1 |
| 16 | Benzocaine-induced methemoglobinemia in an acute-exposure rat model 显示文摘 | VON TUNGELN LINDA S ZHOU T WOODLING K A | 2011 | Food & Chemical Toxicology2011，49，10： | 1 |
| 17 | Delivering small interfering RNA for novel therapeutics显示文摘 | Lu PY Woodle MC | | 0，，： | 1 |
| 18 | Malignancy Mter transplantation 显示文摘 | Buell J F Gross T G Woodle E S | 2005 | Transplantation2005，80，2： | 1 |
| 19 | siRNA-mediated antitumorigenesis for drug target validation and therapeutics显示文摘 | Lu PY Xie FY Woodle MC | 2003 | Curr Opin Mol Ther2003，5，3： | 1 |
| 20 | 查看详情显示文摘 | Fisher JS Woodle ES | | 0，，： | 1 |
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