|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Involvement of cholangiocyte proliferation in biliary fibrosis显示文摘Cholangiocytes are the epithelial cells that line the biliary tree.In the adult liver,they are a mitotically dormant cell population,unless ductular reaction is triggered by injury.The ability of cholangiocytes to proliferate is important in many different human pathological liver conditions that target this cell type,which are termed cholangiopathies(i.e.primary biliary cirrhosis,primary sclerosing cholangitis and biliary atresia).In our article,we provide background information on the morphological and functional heterogeneity of cholangiocytes,summarize what is currently known about their proliferative processes,and briefly describe the diseases that target these cells.In addition,we address recent findings that suggest cholangiocyte involvement in epithelial-to-mesenchymal transformation and liver fibrosis,and propose directions for future studies. | Sally Priester Candace Wise Shannon S Glaser | 2010 | World Journal of Gastrointestinal Pathophysiology2010，1，2： | 10 |
| 2 | Mechanisms of biliary carcinogenesis and growth显示文摘Cholangiocarcinoma is a rare cancer originating from the neoplastic transformation of the epithelial cells (i.e. cholangiocytes) that line the biliary tract. The prognosis for patients with cholangiocarcinoma is grim due to lack of viable treatment options. The increase in world-wide incidence and mortality from cholangiocarcinoma highlights the importance of understanding the intracellular mechanisms that trigger the neoplastic transformation of cholangiocytes and the growth of biliary cancers. The purpose of the following review is to address what has been learned over the past decade concerning the molecular basis of cholangiocarcinogenesis. The material presented is divided into two sections:(1) mechanisms regulating neoplastic transformation of cholangiocytes; and (2) factors regulating cholangiocarcinoma growth. An understanding of the growth regulatory mechanisms of cholangiocarcinoma will lead to the identification of therapeutic targets for this devastating cancer. | Candace Wise Metaneeya Pilanthananond Benjamin F Perry Gianfranco Alpini Michael McNeal Shannon S Glaser | 2008 | World Journal of Gastroenterology2008，14，19： | 5 |
| 3 | High efficiency, high power 808nm laser array and stacked arrays optimized for elevated temperature operation显示文摘Operation of 808-nm laser diode pumping at elevated temperature is crucial to many applications. Reliable operation at high power is limited by high thermal load and low catastrophic optical mirror damage (COMD) threshold at elevated temperature range. We demonstrated high efficiency and high power operation at elevated temperature with high COMD power. These results were achieved through device design optimization such as growth conditions, doping profile, and materials composition of the quantum-well and other layers. Electrical-to-optical efficiency as high as 62% was obtained through lowered threshold current, lowered series resistance and increased slope efficiency. The performance of single broad-area laser diodes scales to that of high power single bars on water-cooled copper micro-channel heatsinks or conductively-cooled CS heatsinks. No reduction in bar performance or significant spectral broadening is seen when these micro-channel coolers are assembled into 6-bar and 18-bar CW stacks for the highest power levels. | Crump P A Crum T R DeVito M Farmer J Grimshaw M Huang Z Igl S A Macomber S Thiagarajan P Wise D | 2004 | 光机电信息2004，21，6： | 4 |
| 4 | Individual patterns of functional reorganization in the human cerebral cortex after capsular infarction显示文摘 | Weiler C Ramsay S Wise R | 1993 | Ann Neurol1993，33，： | 2 |
| 5 | RNA-dependent RNA polymerase gene analysis of worldwide Newcastle disease virus isolates representing different virulence types and their phylogenetic relationship with other members of the paramyxoviridae 显示文摘 | Wise M G Sellers H S Alvarez R | 2004 | Virus Res2004，104，1： | 1 |
| 6 | Effect of interleukin-10 on gene expression of osteoclastogenic regulatory molecules in the rat dental follicle 显示文摘 | Liu D Yao S Wise GE | 2006 | Eur J Oral Sci2006，114，1： | 1 |
| 7 | Traumatic axonal damage in the brain can be detected using beta-APP immunohistochemistry within 35 miniters after head injury to human adults显示文摘 | Hortobagyi T Wise S Hunt N | 2007 | Neurobiol2007，33，2： | 1 |
| 8 | Selectivity and stoichiometry of copper oxide in propylene oxidation显示文摘 | Wood B J Wise H Yolles R S | 1969 | J Catalys1969，15，： | 1 |
| 9 | Regulation of aecretion of osteoptegerin in rat dental follicle cells 显示文摘 | WISE GE DING D YAO S | 2004 | Eur J Oral Sci2004，112，5： | 1 |
| 10 | The feasibility of surgical site tagging with CT virtual reality of paranasal sinuses显示文摘 | Hopper K D Iyriboz A T Wise S W | 1999 | J Comput Assisi Tomogr1999，23，4： | 1 |
| 11 | Determination of organic acids in Vaccinium berry standard reference materials显示文摘 | Phillips M M Case R J Rimmer C A Sander L C Sharpless K E Wise S A Yen J H | 2010 | Analytical and Bioanalytical Chemistry2010，398，1： | 1 |
| 12 | Osteoprotegerin and osteoclast differentiation factor in tooth eruption 显示文摘 | Wise GE Lumpkin S J Huang H | 2000 | J Dent Res2000，79，12： | 1 |
| 13 | Development and validation of a PCR- based enzyme-linked immunosorbent assay with urine for use in clinical research settings to detect Trichomonas vaginalis in women 显示文摘 | KAYDOS S C SWYGARD H WISE S L | 2002 | Clin Microbiol2002，40，1： | 1 |
| 14 | Chronological gene hormone -related protein (PTHrP) in the stellate reticulum of the rat: implications for tooth eruption 显示文摘 | YAO S PAN F WISE expression of parathyroid G E | 2007 | Arch Oral Biol2007，52，3： | 1 |
| 15 | Spatial Stratification in Litter Depth by Forest-Floor Spiders 显示文摘 | WAGNER J G TOFT S WISE D H | 2003 | The Journal of Arachnology2003，31，1： | 1 |
| 16 | Mucosal Detail at CT Virtual Reality: Surfac Eversus Volume Rendering显示文摘 | Hopper K D Iyriboz A T Wise S W | 2000 | Radiology2000，214，2： | 1 |
| 17 | Pressure sensitivity in anisotropically etched thin-diaphragm pressure sensor 显示文摘 | Wise K D | 1979 | IEEE Tran On Electron Devices1979，26，12： | 1 |
| 18 | Nonlinear simulation of tumor necrosis, neo-vascularization and tissue invasionvia an adaptive finite-element/level-set method 显示文摘 | Zheng X Wise S M Cristini V | 2005 | Bull Math Biol2005，211，： | 1 |
| 19 | Effect of interleukin-10 on gene expression of osteoclastogenic regulatory molecules in the rat dental follicle 显示文摘 | LIU D YAO S WISE G E | 2006 | Eur J Oral Sci2006，114，1： | 1 |
| 20 | Integrating GIS and spatial analysis:Problems and possibilities显示文摘 | GOODCHILD M F HAINING R P WISE S | 1992 | Interna- tional Journal of Geographical Information Systems1992，6，5： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员