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| 1 | Fecal microbiota transplantation as novel therapy in gastroenterology:A systematic review显示文摘AIM:To study the clinical efficacy and safety of Fecal microbiota transplantation(FMT).We systematically reviewed FMT used as clinical therapy.METHODS:We searched MEDLINE,EMBASE,the Cochrane Library and Conference proceedings from inception to July,2013.Treatment effect of FMT was calculated as the percentage of patients who achieved clinical improvement per patient category,on an intention-to-treat basis.RESULTS:We included 45 studies;34 on Clostridium difficile-infection(CDI),7 on inflammatory bowel disease,1 on metabolic syndrome,1 on constipation,1 on pouchitis and 1 on irritable bowel syndrome(IBS).In CDI 90% resolution of diarrhea in 33 case series(n = 867) was reported,and 94% resolution of diarrhea after repeated FMT in a randomized controlled trial(RCT)(n = 16).In ulcerative colitis(UC) remission rates of 0% to 68% were found(n = 106).In Crohn's disease(CD)(n = 6),no benefit was observed.In IBS,70% improvement of symptoms was found(n = 13).100% Reversal of symptoms was observed in constipation(n = 3).In pouchitis,none of the patients(n = 8) achieved remission.One RCT showed significant improvement of insulin sensitivity in metabolic syndrome(n = 10).Serious adverse events were rare.CONCLUSION:FMT is highly effective in CDI,and holds promise in UC.As for CD,chronic constipation,pouchitis and IBS data are too limited to draw conclusions.FMT increases insulin sensitivity in metabolic syndrome. | Noortje G Rossen John K Mac Donald Elisabeth M de Vries Geert R D'Haens Willem M de Vos Erwin G Zoetendal Cyriel Y Ponsioen | 2015 | World Journal of Gastroenterology2015，21，17： | 41 |
| 2 | Inhibition of the B7-H3 immune checkpoint limits tumor growth by enhancing cytotoxic lymphocyte function显示文摘在肿瘤和免疫系统之间的相互作用仍然糟糕被理解。重要临床的回答在对 CTLA4 和 PD-1/PD-L1 检查点与抗体对待的癌症病人被完成了;然而,仅仅病人的小部分对治疗作出回应,显示需要探索为癌症治疗的另外的 co 禁止的分子。B7-H3, B7 总科的一个成员,被我们以前显示出禁止 T 房间激活和 autoimmunity。在这研究,我们在肿瘤免疫分析了 B7-H3 的功能。B7-H3 的表示在多重肿瘤线,渗入肿瘤的树枝状的房间,和巨噬细胞被发现。与对抗抗体对待到 B7-H3 的 B7-H3-deficient 老鼠或老鼠显示出多重肿瘤的减少的生长,它取决于 NK 和 CD8 + T 房间。与细胞毒素的淋巴细胞表示的通常认为的受体, B7-H3 禁止了他们的激活,并且它的缺乏在忍受肿瘤的鼠标导致了增加的细胞毒素的淋巴细胞功能。B7-H3 和 PD-1 的联合封锁导致了迟了阶段的肿瘤的进一步提高的治疗学的控制。一起拿,我们的结果显示 B7-H3 检查点可以对癌症为免疫疗法用作一个新奇目标。 | Young-hee Lee Natalia Martin-Orozco Peilin Zheng Jing Li Peng Zhang Haidong Tan Hyun Jung Park Mira Jeong Seon Hee Chang Byung-Seok Kim Wei Xiong Wenjuan Zang Li Guo Yang Liu Zhong-jun Dong Willem W Overwijk Patrick Hwu Qing Yi Larry Kwak Zhiying Yang Tak W Mak Wei-Li Laszlo G Radvanyi Ling Ni Dongfang Liu Chen Dong | 2017 | Cell Research2017，27，8： | 29 |
| 3 | Colonic stenting versus emergency surgery for acute left-sided malignant colonic obstruction: a multicentre randomised trial显示文摘 | Jeanin E van Hooft Willem A Bemelman Bas Oldenburg Andreas W Marinelli Martijn F Lutke Holzik Marina J Grubben Mirjam A Sprangers Marcel G Dijkgraaf Paul Fockens | 2011 | Lancet Oncology2011，，4： | 3 |
| 4 | Coronary artery disease in congenital single coronary artery in adults:A Dutch case series显示文摘AIM:To assess the current diagnostic and therapeutic management and the clinical implications of congenital single coronary artery(SCA) in adults.METHODS:We identified 15 patients with a SCA detected from four Dutch angiography centers in the period between 2010 and 2013.Symptomatic patients who underwent routine diagnostic coronary angiography(CAG) for suspected coronary artery disease and who incidentally were found to have isolated SCA were analyzed.RESULTS:Fifteen(7 females) with a mean age of 58.5 ± 13.78 years(range 43-86) had a SCA.ConventionalCAG demonstrated congenital isolated SCA originating as a single ostium from the right sinus of Valsalva in 6 patients and originating from the left in 9 patients.Minimal to moderate coronary atherosclerotic changes were found in 4,and severe stenotic lesions in another 4 patients.Seven patients were free of coronary atherosclerosis.Runs of non-sustained ventricular tachycardia were documented in 2 patients,one of whom demonstrated transmural ischemic changes on presentation.Myocardial perfusion scintigraphic evidence of transmural myocardial ischemia was found in 1 patient due to kinking and squeezing of the SCA with an interarterial course between the aorta and pulmonary artery.Multi-slice computed tomography(MSCT) was helpful to delineate the course of the anomalous artery relative to the aorta and pulmonary artery.Percutaneous coronary intervention was successfully performed in 3 patients.Eight patients were managed medically.Arterial bypass graft was performed in 4 patients with the squeezed SCA.CONCLUSION:SCA may be associated with transient transmural myocardial ischemia and aborted sudden death in the absence of coronary atherosclerosis.The availability and sophistication of MSCT facilitates the delineation of the course of a SCA.We present a Dutch case series and review of the literature. | Salah AM Said Willem G de Voogt Suat Bulut Jacques Han Peter Polak Rogier LG Nijhuis Jeroen W op den Akker Andries Slootweg | 2014 | World Journal of Cardiology2014，6，4： | 3 |
| 5 | Evaluation and inter-comparison of Global Climate Models' performanee over Katonga and Buizi catchments in Lake Victoria Basin 显示文摘 | Nyeko-Ogiramoi P Ngirane-Katashaya G Willems P | 2010 | Physics and Chemistry of the Earth2010，35，1314： | 1 |
| 6 | AHTN and HHCB show weak estrogenic-butno uterotrophic activity显示文摘 | Willem Seinen Josephine G Lemmen Raymond H HPieters et a1 | 1999 | Toxicology Letters1999，111，： | 1 |
| 7 | Outcome of proximal internal iliac artery coil embolization prior to stent-graft extension in patients previously treated by endovascular aortic repair显示文摘 | Maleux G Willems E Vaninbroukx J | 2010 | J Vasc Interv Radiol2010，21，7： | 1 |
| 8 | Influence of the Pt electrode on the properties of sol-gel PZT-films显示文摘 | Willems G J Wouters D J Maes H E | 1995 | Microelectronic Engineering1995，29，14： | 1 |
| 9 | 显示文摘 | Willems J J G Buschow K H | 1987 | J Les-Common Met1987，13，： | 1 |
| 10 | Reduced prefrontal glutamate/ glutamine and gamma-aminobutyric acid levels in major depression determined using proton magnetic resonance spectroscopy 显示文摘 | Hasler G Willem J Tumonis T | 2007 | Areh Gen Psychiatry2007，64，： | 1 |
| 11 | An integrated approachfor visual analysis of a multisource moving objectsknowledge base 显示文摘 | Willems N van Hage W R de Vries G | 2010 | International Journal of Geographical InformationScience2010，24，10： | 1 |
| 12 | Multi-detector row CT systems and imaging reconstruction techniques显示文摘 | Thomas G Stefan S Willems TP | 2005 | Radiology2005，235，3： | 1 |
| 13 | 显示文摘 | Willems J J G | 1983 | Philips J Res1983，1，1： | 1 |
| 14 | Assessment of glomerular filtration rate in healthy subjects and normoalbuminuric diabetic patients:validity of a new (MDRD) prediction equation显示文摘 | Vervoort G Willems HL Wetzels JF | 2002 | Nephrol Dial Transplant2002，17，： | 1 |
| 15 | 显示文摘 | Judith E G Wijnhoven J Willem L V | 1998 | Science1998，281，： | 1 |
| 16 | Assessment of glomerular filtration rate in healthy subjects and normoalbuminuric diabetic patients:validity of a new (MDRD) prediction equation显示文摘 | VERVOORT G WILLEMS H L WETZELS J F | 2002 | Nephrol Dial Transplant2002，17，11： | 1 |
| 17 | HRS/ EHRA expert consensus statement on the state of genetic testing for the channelopathies and cardiomyopathies this document was developed as a partnership between the Heart Rhythm Society (HRS) and the European Heart Rhythm Association(EHRA) 显示文摘 | ACKERMAN M J PRIORI S G WILLEMS S | 2011 | Heart Rhythm2011，8，8： | 1 |
| 18 | Spinal osteotomy in patients with ankylosing spondylitis: complications during first postoperative year显示文摘 | Willems K F Slot G H Anderson P G | 2005 | Spine2005，30，1： | 1 |
| 19 | Dental age estimation in Belgian children:Demirjian's Technique revisited显示文摘 | G Willems A Van Olmen B Spiessens | 2001 | J Forensic Sci2001，46，4： | 1 |
| 20 | Nonsyndromic hearing impairment:Unpairalleled heterogeneity显示文摘 | Willems P J Smith R J H | 1997 | Am J Hum Genet1997，60，： | 1 |
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