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| 1 | Fecal microbiota transplantation as novel therapy in gastroenterology:A systematic review显示文摘AIM:To study the clinical efficacy and safety of Fecal microbiota transplantation(FMT).We systematically reviewed FMT used as clinical therapy.METHODS:We searched MEDLINE,EMBASE,the Cochrane Library and Conference proceedings from inception to July,2013.Treatment effect of FMT was calculated as the percentage of patients who achieved clinical improvement per patient category,on an intention-to-treat basis.RESULTS:We included 45 studies;34 on Clostridium difficile-infection(CDI),7 on inflammatory bowel disease,1 on metabolic syndrome,1 on constipation,1 on pouchitis and 1 on irritable bowel syndrome(IBS).In CDI 90% resolution of diarrhea in 33 case series(n = 867) was reported,and 94% resolution of diarrhea after repeated FMT in a randomized controlled trial(RCT)(n = 16).In ulcerative colitis(UC) remission rates of 0% to 68% were found(n = 106).In Crohn's disease(CD)(n = 6),no benefit was observed.In IBS,70% improvement of symptoms was found(n = 13).100% Reversal of symptoms was observed in constipation(n = 3).In pouchitis,none of the patients(n = 8) achieved remission.One RCT showed significant improvement of insulin sensitivity in metabolic syndrome(n = 10).Serious adverse events were rare.CONCLUSION:FMT is highly effective in CDI,and holds promise in UC.As for CD,chronic constipation,pouchitis and IBS data are too limited to draw conclusions.FMT increases insulin sensitivity in metabolic syndrome. | Noortje G Rossen John K Mac Donald Elisabeth M de Vries Geert R D'Haens Willem M de Vos Erwin G Zoetendal Cyriel Y Ponsioen | 2015 | World Journal of Gastroenterology2015，21，17： | 41 |
| 2 | Double balloon endoscopy associated pancreatitis:A description of six cases显示文摘AIM:To perform a single-center analysis of all double balloon endoscopy (DBE) related cases of pancreatitis identified prospectively from a recorded DBE-complication database. METHODS:From November 2003 until January 2007, 603 DBE procedures were performed on 412 patients, with data on complications recorded in a database. The setting was a tertiary care center offering DBE. DBE was performed from the antegrade or retrograde route. Out-come measurements included age, gender, medication, indication, DBE-endoscope type, insertion depth, proce-dure duration, findings, interventions, post-procedural abdominal pain, and post-procedural hospitalization. RESULTS:This is the largest single-center study report-ing on post-DBE pancreatitis prospectively. Six patients (1.0%) developed post-DBE pancreatitis, all after antegrade DBE. There was no association with gender, duration of the procedure or type of endoscope. The mean age was 51.9 years (range 25-78). Four patients had severe pancreatitis. Of these, two had inflammatory signs in the body-tail region, one had pancreatitis in the tail region, and the total pancreas was involved in one. CONCLUSION:The incidence of post-DBE pancreatitis in our series is higher than previously reported. We found no relation with DBE-endoscope type. The inflammatory changes occurred in the body-tail region of the pancreas, suggesting that post-DBE pancreatitis is caused by repetitive mechanical strain on the pancreas. | Soeresh VA Jarbandhan Stijn JB van Weyenberg Willem M van der Veer Dimitri GN Heine Chris JJ Mulder Maarten AJM Jacobs | 2008 | World Journal of Gastroenterology2008，14，5： | 8 |
| 3 | Mobilization of hematopoietic progenitor cells in patients with liver cirrhosis显示文摘AIM:To test the hypothesis that liver cirrhosis is associated with mobilization of hematopoietic progenitor cells. METHODS:Peripheral blood samples from 72 patients with liver cirrhosis of varying etiology were analyzed by flow cytometry.Identified progenitor cell subsets were immunoselected and used for functional assays in vitro. Plasma levels of stromal cell-derived factor-1(SDF-1) were measured using an enzyme linked immunosorbent assay.RESULTS:Progenitor cells with a CD133 + /CD45 + CD14 + phenotype were observed in 61%of th patients.Between 1%and 26%of the peripheral bloo mononuclear cells(MNCs)displayed this phenotype Furthermore,a distinct population of c-kit + progenito cells(between 1%and 38%of the MNCs)could b detected in 91%of the patients.Additionally,18% of the patients showed a population of progenito cells(between 1%and 68%of the MNCs)that wa characterized by expression of breast cancer resistanc protein-1.Further phenotypic analysis disclosed tha the circulating precursors expressed CXC chemokin receptor 4,the receptor for SDF-1.In line with thi finding,elevated plasma levels of SDF-1 were presen in all patients and were found to correlate with th number of mobilized CD133 + progenitor cells. | Ursula M Gehling Marc Willems Kathleen Schlagner Ralf A Benndorf Maura Dandri Jrg Petersen Martina Sterneck Joerg-Matthias Pollok Dieter K Hossfeld Xavier Rogiers | 2010 | World Journal of Gastroenterology2010，16，2： | 4 |
| 4 | 拉科酰胺在癫痫持续状态中的应用--针对现有证据的系统评价显示文摘拉科酰胺(Lacosamide,LCM)的静脉制剂具有良好的耐受性和安全性,促使其在癫痫持续状态(Status Epilepticus,SE)中得到应用。本项系统评价的目的是确定和评估LCM在SE中的使用情况。在电子数据库中用联合检索方式对2008年—2016年10月的文献进行了系统检索,并使用标准化的评估表格从各项研究中将有关研究设计、方法框架、数据源、有效性和LCM引起的不良反应的信息进行提取并系统地报告。研究共评估了522次SE发作,其中包括486例成人和36例儿童及青少年发作,女性占51.7%。LCM的总体效力为57%。LCM对非惊厥性(57%,82/145)和全面痉挛性(61%,30/49,P=0.68)SE的效力相似,但对局灶运动性SE的总体有效率更高(92%,34/39,P<0.001)。而LCM在用药次序靠后时其疗效从100%下降到20%。治疗期间的主要不良反应是眩晕,视力异常,复视和共济失调。总体而言,LCM具有良好的耐受性,并且没有具临床意义的药物相互作用。现有数据表明LCM在SE中的使用是有前景的,有效率为57%。LCM的优势在于没有潜在的药物相互作用,并且在紧急情况需迅速增加剂量时可静脉使用。 | Adam Strzelczyk Johann Philipp Zollner Laurent M Willems 肖英凤 童馨 慕洁 Julie Jost Esther Paule Susanne Schubert-Bast Felix Rosenow Sebastian Bauer | 2018 | 癫痫杂志2018，4，5： | 2 |
| 5 | Bacterial carbonate precipitation as an alternative surface treatment for concrete显示文摘 | Willem D M Kathelijn C Nele D B | 2008 | Construction and Building Materials2008，22，5： | 1 |
| 6 | Modeling piezoelectric actuators显示文摘 | Willem L | 2000 | IEEE/ASME Transactions on Mechatronics2000，5，4： | 1 |
| 7 | Identification of uncertainty sources in distributed hydrological modelling: Case study of the Grote Nete catchment in Belgium 显示文摘 | Rubarenzya M H Willems P Berlamont J | 2007 | Water SA2007，33，： | 1 |
| 8 | Applications of Local Linking to Critical Point theory显示文摘 | Li Shujie Willem M | 1995 | J Math Anal Appl1995，189，： | 1 |
| 9 | Antimicrobial peptides from plants显示文摘 | Willem F B Cammue B P A De Bone M F C | 1997 | Critical Reviews in Plant Sciences1997，16，3： | 1 |
| 10 | Global spread of vancomycin-resistant Enterococcus faecium from distinct noso-comiai genetic complex显示文摘 | Willems RJ Top J van Santen M | 2005 | Emerg Infect Dis2005，11，6： | 1 |
| 11 | Cullinbasedubiquitinligases:Cul3BTB complexes join the family显示文摘 | Pintard L Willem A Peter M | 2004 | EMBO J2004，23，8： | 1 |
| 12 | Response of turbine flow meters to acoustic per- turbations显示文摘 | STOLTENKAMP P W BERGERVOET J T M WILLEMS J F H | 2008 | Journal of Sound Vibration2008，315，12： | 1 |
| 13 | Selective dorsal rhizotomy in cerebral palsy to improve functional abilities:evaluation of criteria for selection显示文摘 | PETRA E M JEROEN V WILLEM J R | 2005 | Childs Nerv Syst2005，21，6： | 1 |
| 14 | Solitary waves with prescribed speed on infinite lattices 显示文摘 | Smets D Willem M | 1977 | Journal of Functional Analysis1977，149，1： | 1 |
| 15 | Homoelinic orbit for a class of Hamiltonian systems显示文摘 | Omaha W Willem M | 1992 | Diff lnt Eqns1992，5，5： | 1 |
| 16 | Dislocation distributions in brown diamond显示文摘 | WILLEMS B MARTINEAU P M FISHER D | 2006 | Physical Status Solid2006，12，： | 1 |
| 17 | Homoclinic orbits for a class of Hamiltonian systems显示文摘 | Omana W Willem M | | 0，，： | 1 |
| 18 | Non-radial ground states for the Hénon equation显示文摘 | Smets D SU Jiabao Willem M | | 0，，： | 1 |
| 19 | Knowledge sharing in public sector organizations:the effect of organizational characteristics on inter-departmental knowledge sharing显示文摘 | WILLEM A BUELENS M | | 0，，14： | 1 |
| 20 | The phylogeny of the genus Clostridium: proposal of five new genera and eleven new species eombinations显示文摘 | COLLINS M D LAWSON P A WILLEMS A | 1994 | Int J Syst Baeteriol1994，44，4： | 1 |
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