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| 1 | The immunology of human cytomegalovirus latency: could latent infection be cleared by novel immunotherapeutic strategies?显示文摘当跟随主要人的 cytomegalovirus (HCMV ) 感染的主人免疫者反应在停止病毒复制和传播通常是有效的时,病毒从来没被主人并且象所有 herpesviruses 一样清除,永久坚持。至少部分地,这坚持被知道被 HCMV 的能力便于在感染是实质上沉默的与的 myeloid 在房间建立潜伏,重要地新病毒生产的全部的缺乏。然而,尽管病毒的抄写计划很在潜伏期间被压制,很多病毒的基因在蛋白质水平在潜伏的感染期间被表示,这些中的许多被显示了在潜伏的房间和它的环境上有深刻效果。有趣地,许多也在 lysin 的感染期间这些联系潜伏的基因被表示。因此,一样的有势力主人免疫者回答为什么在 lysin 的感染期间产生了到这些病毒的基因产品,没在潜伏期间被认出,从而允许隐而不见地的感染的房间的清理,是远非清楚的。从潜伏的复活也是调停 HCMV 的疾病的一个主要原因,特别地在损害的免疫者和免疫者天真,并且也是可能的是在被建议了与象动脉粥样硬化和一些瘤形成那样的长期的疾病被联系的长期的无临床症状的 HCMV 感染的病毒的主要来源。因而,理解潜伏并且隐而不见地的感染的房间为什么看起来是 immunoprivileged,为 HCMV 的致病的理解是关键的并且可以帮助设计策略消除潜伏的病毒水库,至少在某些临床的背景。 | Mark R Wills Emma Poole Betty Lau Ben Krishna John H Sinclair | 2015 | Cellular & Molecular Immunology2015，12，2： | 6 |
| 2 | Preslaughter diet management in sheep and goats:effects on physiological responses and microbial loads on skin and carcass显示文摘Sixteen crossbred buck goats(Kiko x Spanish;BW = 32.8 kg) and wether sheep(Dorset x Suffolk;BW = 39.9 kg) were used to determine the effect of preslaughter diet and feed deprivation time(FDT) on physiological responses and microbial loads on skin and carcasses.Experimental animals were fed either a concentrate(CD) or a hay diet(HD)for 4 d and then deprived of feed for either 12-h or 24-h before slaughter.Blood samples were collected for plasma Cortisol and blood metabolite analyses.Longisimus muscle(LM) pH was measured.Skin and carcass swabs were obtained to assess microbial loads.Plasma creatine kinase activity(863.9 and 571.7 ± 95.21 IU) and non-esterified fatty acid concentrations(1,056.1 and 589.8 + 105.01 mEq/L) were different(P< 0.05) between sheep and goats.Species and diet treatments had significant effects on the ultimate pH of LM.Pre-holding total coliform(TCC) and aerobic plate counts(APC) of skin were significantly different between species.Goats had lower(P < 0.05) TCC(2.1 vs.3.0 log_(10) CFU/cm^2) and APC(8.2 vs.8.5 log_(10) CFU/cm^2) counts in the skin compared to sheep.Preslaughter skin E.coli counts and TCC were different(P < 0.05) between species.Goats had lower(P < 0.05) counts of E.coli(2.2 vs.2.9 log_(10) CFU/cm^2) and TCC(2.3 vs.3.0 log_(10) CFU/cm^2) in the skin compared with those in sheep.Diet,species,and FDT had no effect(P> 0.05) on E.coli and TCC in carcass swab samples.The APC of carcass swab samples were only affected(P < 0.05) by the FDT.The results indicated that preslaughter dietary management had no significant changes on hormone and blood metabolite concentrations and sheep might be more prone for fecal contamination than goats in the holding pens at abattoir. | Govind Kannan Venkat R Gutta Jung Hoon Lee Brou Kouakou Will R Getz George W McCommon | 2015 | Journal of Animal Science and Biotechnology2015，6，1： | 2 |
| 3 | Effect of acute and established anemia on O2 transport at rest, submaximal and maximal work显示文摘 | WOODSON R D WILLS R E LENFANT C | 1978 | J Appl Physiol1978，44，1： | 1 |
| 4 | Harnessing senescence delaying gases nitric oxide and nitrous oxide:a novel approach to postharvest control of fresh horticultural produce显示文摘 | Leshem Y Y Wills R B H | 1998 | Biologicat Plantacum1998，41，1： | 1 |
| 5 | Duration of infection and proportion of pigs persistently infected with porcine reproductive and respiratory syndrome virus显示文摘 | Wills R W Doster A R Galeota J A | 2003 | J Clin Microbiol2003，41，1： | 1 |
| 6 | Evidence for the function of the free radical gas - nitric oxide (NO) - as an endogenous maturation and senescence regulating factor in higher plants 显示文摘 | Leshem Y Y Wills R B H Ku V V V | 1998 | Plant Physiol Biochem1998，36，： | 1 |
| 7 | A triadic approach to formal concept analysis显示文摘 | LEHMANN F WILLE R | 1995 | Lecture Notes in Computer Science1995，954，： | 1 |
| 8 | Chemistry and clinical biology of the bryostatins 显示文摘 | Mutter R Wills M | 2000 | Bioorg Med Chem2000，8，： | 1 |
| 9 | A new variant of Creutzfeldt-Jakob disease in the UK显示文摘 | Will R G Ironside Zeidler | 1996 | Lancet1996，347，： | 1 |
| 10 | Inter-company comparison using modified TOPSIS with objective weights显示文摘 | Wills R J | 2000 | Computers & Operations Research2000，27，10： | 1 |
| 11 | Spliceosomal UsnRNP biogenesis,structure and function显示文摘 | Will CL Luhrmann R | 2001 | Curr Opin Cell Biol2001，13，： | 1 |
| 12 | Spliceosome structure and function 显示文摘 | Will CL Ltihrmann R | 2011 | Cold Spring Harb Perspect Biol2011，3，00： | 1 |
| 13 | Optimization of storage conditions for shogur broccoli显示文摘 | Klieber A R Wills B H | | 0，，： | 1 |
| 14 | Duration of infection and proportion of pigs persistently infected with porcine reproductive and respiratory syndrome virus 显示文摘 | Wills R W Doster A R Galeota J A | | Journal of Clinical Microbiology0，41，1： | 1 |
| 15 | The human cytotoxic T lymphocyte (CTL) response to cytomegalovirus is dominated by structural protein pp65 : frequency, specificity, and T cell receptor usage of pp65-sepcific CTL显示文摘 | Wills M R Carmichael A J Mymard K | 1996 | J Virol1996，70，： | 1 |
| 16 | A phase Ⅱ study of Rituximab in rheumatoid arthritis patients with recurrent disease following haematopoietic stem cell transplantation显示文摘 | Moore J Ma D Will R | 2004 | Bone Marrow Transplant2004，34，： | 1 |
| 17 | Genes expressed in the male gametophyte of flowering plants and their isolation显示文摘 | Stinson J R Eisenberg A J Willing R P | 1987 | Plant Physiology1987，83，： | 1 |
| 18 | Interstital lung disease in recent-onset rheumatoid arthritis显示文摘 | Gabbay E Tarala R Will R | 1997 | Am J Respir Grit Cɑre Med1997，156，： | 1 |
| 19 | Evidence for the function of the free radical gas-nitric oxide (NO)-as an endogenous maturation and senescence regulating factor in higher plants显示文摘 | Leshem Y Y Wills R B H Ku V V V | 1998 | Plant Physiol Biochem1998，36，11： | 1 |
| 20 | Recovery from brain injury in an- imals: relative efficacy of environmental enrichment, physical exercise or formal training ( 1990 - 2002) 显示文摘 | Will B Galani R Kelch C | 2004 | Prog Neurobiol2004，72，3： | 1 |
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