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| 1 | Reduced bone mineral density and altered bone turnover markers in patients with non-cirrhotic chronic hepatitis B or C infection显示文摘AIM: Previous studies suggest that loss of bone mineral density (BMD) frequently occurs in patients with chronic viral liver disease, presenting with histologically proven liver cirrhosis. However, little is known about the occurrence of bone disease in non-cirrhotic patients with chronic hepatitis B or C. Therefore, it was the aim of this study to evaluate this particular population for BMD and bone turnover markers.METHODS: Biochemical markers of bone turnover and BMD were measured in 43 consecutive patients with HCV (n = 30)or HBV (n = 13) infection without histological evidence for liver cirrhosis. Mean age was 49 years (range 26-77 years). BMD was measured by dual X-ray absorptiometry in the femoral neck (FN) and the lumbar spine (LS) region. In addition, bone metabolism markers were measured.RESULTS: BMD was lowered in 25 (58%) of the patients with chronic hepatitis B or C (FN: 0.76 (0.53-0.99); LS:0.96 (0.62-1.23) g/cm2). Eight (32%) osteopenic patients were diagnosed with osteoporosis. Bone-specific alkaline phosphatase (P = 0.005) and intact parathyroid hormone (iPTH) (P = 0.001) were significantly elevated in the more advanced stages of fibrosis. Mean 7-score value was lower in patients with chronic hepatitis C as compared to patients suffering from chronic hepatitis B; however, the difference was not statistically significant (P = 0.09).CONCLUSION: There was a significantly reduced BMD in non-cirrhotic patients with chronic hepatitis B or C infection. Alterations of bone metabolism already occurred in advanced liver fibrosis without cirrhosis. According to our results, these secondary effects of chronic viral hepatitis should be further investigated. | Ingolf Schiefke Andreas Fach Marcus Wiedmann Andreas V.Aretin Eva Schenker Gudrun Borte Manfred Wiese Joachim Moessner | 2005 | World Journal of Gastroenterology2005，11，12： | 23 |
| 2 | 海洋放线菌——新活性代谢物的重要来源(英文)显示文摘放线菌是一类产生活性代谢物最多的微生物资源。目前人类认识的活性代谢物有22000余种,其中10100多种由放线菌产生。海洋覆盖了75%的地表面积,为发现新活性化合物和新用途提供了巨大的潜在资源。本文简要评述了海洋放线菌的多样性及其产生的活性物质的种类与功能(包括:酶抑制剂、抗肿瘤化合物、抗菌物质和其他活性代谢物),讨论了新放线菌活性代谢物开发中值得重视的几个问题以及研究前景。 | 姜怡 Jutta Wiese 徐丽华 Johannes F.Imhoff 姜成林 | 2007 | 中国抗生素杂志2007，32，12： | 12 |
| 3 | 超重力法合成纳米碳酸钙的研究(Ⅰ)最佳反应时间的确定显示文摘采用红外光谱法动态跟踪研究在超重力法下合成纳米碳酸钙的整个碳化过程。实验表明 ,该方法得到的结果符合常规 pH计与电导仪记录的转化点 ,并与电镜形貌分析观察到晶形完全转化为立方型的反应时间相吻合。 | 朱开明 刘春光 饶国瑛 王玉红 陈建峰 Harm Wiese | 2001 | 北京化工大学学报(自然科学版)2001，28，3： | 8 |
| 4 | 纳米CaCO_3合成及原位改性的研究显示文摘在旋转填充床反应器中合成了纳米CaCO3悬浮液,利用pH计跟踪Ca(OH)2碳化反应过程, 研究了碳化反应过程原理。结果表明:旋转填充床能极大地强化相间传质与微观混合,提高体系中CaCO3的过饱和度,增大其成核及生长速率。加入适当的添加剂对纳米CaCO3进行原位改性; 利用TEM照片研究了原位改性过程中纳米CaCO3的成核生长机理,并考察了添加剂的作用机理。 | 刘春光 朱开明 王玉红 陈建峰 饶国英 Harm Wiese | 2001 | 高校化学工程学报2001，15，5： | 6 |
| 5 | 磨矿介质材质与捕收剂添加方式对某铜镍硫化矿浮选的影响显示文摘通过磨矿和浮选试验研究了低碳钢和不锈钢两种磨矿介质与捕收剂添加方式对某铜镍硫化矿(Nkomati矿)浮选的影响。试验研究使用实验室用圆筒形棒磨机和机械搅拌式挂槽浮选机完成,通过浮选水回收率、精矿产率和有用矿物回收率分析了磨矿介质和捕收剂添加方式对铜镍硫化物浮选行为的影响。研究中对矿浆pH值、氧化还原电位(Eh)和溶解氧(Do)等溶液化学性质进行了测定,以考察磨矿介质及捕收剂添加方式对溶液化学性质的影响。磨矿介质对Nkomati矿的矿浆溶液化学性质和浮选行为具有显著影响,经低碳钢磨矿后,具有较高的铜、镍和磁黄铁矿回收率,EDTA可浸出铁的含量更高,Do值更低。不同磨矿介质磨矿条件下,捕收剂添加方式对铜镍矿浮选的影响规律不同,低碳钢磨矿时,捕收剂添加在浮选槽中的铜回收率较高;不锈钢磨矿时,捕收剂添加在磨机中的铜和镍的回收率较高。 | 宋振国 K Corin J G Wiese C T O'Connor | 2017 | 矿产保护与利用2017，37，6： | 6 |
| 6 | APP physiological and pathophysiological functions: insights from animal models显示文摘淀粉的先锋蛋白质(应用软件) 在最近的年里的集中的学习下面,主要由于它在 Alzheimer 的疾病(广告) 的致病的关键角色。β淀粉(Aβ) 从应用软件解朊的劈开产生的肽能聚集,在人的广告大脑导致匾形成。削尖影响 Aβ 的应用软件的变化;生产被发现为世袭早发作原因家庭广告。它是很可能的那阐明应用软件的生理的性质将极大地在广告致病便于它的角色的理解。很多个应用软件 loss-of-function 和 gain-of-function 模型包括 Caenorhabditis elegans,果蝇, zebrafish 和老鼠在模型有机体被建立了。这些在 vivo 模型提供我们珍贵卓见进应用软件生理的函数。另外,几只敲门在里面老鼠当模特儿在生理的水平表示变异的应用软件是可得到的允许我们没有应用软件 overexpression,学习广告致病。这篇文章将考察生理的水流和应用软件的 pathophysiological 动物模型。 | Qinxi Guo Zilai Wang Hongmei Li Mary Wiese Hui Zheng | 2012 | Cell Research2012，22，1： | 5 |
| 7 | Potential of embryonic and adult stem cells in vitro显示文摘 | Czyz J Wiese C Rolletschek A | 2003 | Biol Chem2003，384，1011： | 5 |
| 8 | Alloying effect of silver in magnesium on the development of microstructure and mechanical properties by indirect extrusion显示文摘The effect of Ag in solid solution on the microstructure,texture and the deformation behaviour of indirectly extruded Mg was investigated.Ag as a solid solution strengthener affects the behaviour during extrusion,resulting in enhanced deformation related heating and corresponding coarser grained microstructures.No substantial effect on the texture development is revealed.The mechanical properties simultaneously increase in stress and strain levels with increasing Ag content,especially in tension as a result of the changing impact of the slip modes which can be associated with a decrease of the lattice parameters as well as the c/a ratio of the hcp lattice structure.In compression tests with twin dominated flow,the impact is much smaller on the compressive yield stress but higher with respect to the twinning related strain hardening rate.Solid solution strength functions for Fleischer and Labusch were determined,also confirming the anisotropic behaviour of the extruded Mg alloys. | Bjorn Wiese Regine Willumeit-Römer Dietmar Letzig Jan Bohlen | 2021 | Journal of Magnesium and Alloys2021，9，1： | 3 |
| 9 | Deteriorated corrosion performance of micro-alloyed Mg-Zn alloy after heat treatment and mechanical processing显示文摘The corrosion performances of the as-cast and solution-treated Mg-0.5Zn samples were investigated in 0.9%Na Cl solution and compared.From the electrochemical measurement results and corrosion morphology observations,it is found that the corrosion resistance of Mg-0.5Zn deteriorated with the extension of solution treatment duration.The main reason was the formation of Fe-Si precipitates with higher Fe concentrations during heat treatment.The Fe-Si precipitates,especially the ones with high Fe contents influenced the corrosion initiation and propagation significantly.In regard of corrosion performance,the solution-treated and then extruded sample was also performing not as good as the cast and then directly extruded sample. | Yiming Jin Carsten Blawert Hong Yang Bjorn Wiese Jan Bohlen Di Mei Min Deng Frank Feyerabend Regine Willumeit | 2021 | Journal of Materials Science & Technology2021，，33： | 3 |
| 10 | Factors influencing the spinal motoneurons in development显示文摘The development of the spinal cord needs a concerted interaction of transcription factors activating diverse genes and signals from outside acting on the specification of the different cells. Signals have to act on the segments of the embryo as well as on the cranial-caudal axis and the dorso-ventral axis. Additionally the axons of the motoneurons have to cross the central nervous system barrier to connect to the periphery. Intensive anatomical studies have been followed by molecular characterization of the different subsets of transcription factors that are expressed by cells of the developing spinal cord. Here, intensive studies for the most important appearing cells, the motoneurons, have resulted in a good knowledge on the expression patterns of these proteins. Nonetheless motoneurons are by far not the only important cells and the concert activity of all cells besides them is necessary for the correct function and integrity of motoneurons within the spinal cord. This article will briefly summarize the different aspects on spinal cord development and focuses on the differentiation as well as the functionalization of motoneurons. | Stefan Wiese | 2015 | Neural Regeneration Research2015，10，11： | 2 |
| 11 | High-resolution ex vivo analysis of the degradation and osseointegration of Mg-xGd implant screws in 3D显示文摘Biodegradable magnesium(Mg)alloys can revolutionize osteosynthesis,because they have mechanical properties similar to those of the bone,and degrade over time,avoiding the need of removal surgery.However,they are not yet routinely applied because their degradation behavior is not fully understood.In this study we have investigated and quantified the degradation and osseointegration behavior of two biodegradable Mg alloys based on gadolinium(Gd)at high resolution.Mg-5Gd and Mg-10Gd screws were inserted in rat tibia for 4,8 and 12 weeks.Afterward,the degradation rate and degradation homogeneity,as well as bone-to-implant interface,were studied with synchrotron radiation micro computed tomography and histology.Titanium(Ti)and polyether ether ketone(PEEK)were used as controls material to evaluate osseointegration.Our results showed that Mg-5Gd degraded faster and less homogeneously than Mg-10Gd.Both alloys gradually form a stable degradation layer at the interface and were surrounded by new bone tissue.The results were correlated to in vitro data obtained from the same material and shape.The average bone-to-implant contact of the Mg-xGd implants was comparable to that of Ti and higher than for PEEK.The results suggest that both Mg-xGd alloys are suitable as materials for bone implants. | Diana Krüger Silvia Galli Berit Zeller-Plumhoff D.C.Florian Wieland Niccolo Peruzzi Bjorn Wiese Philipp Heuser Julian Moosmann Ann Wennerberg Regine Willumeit-Romer | 2022 | Bioactive Materials2022，7，7： | 2 |
| 12 | Outcome in a hepatitis C (genotype 1b) single source outbreak in Germany—a 25-year multicenter study显示文摘 | Manfred Wiese Kurt Grüngreiff Wolfgang Güthoff Michael Lafrenz Ute Oesen Heiner Porst | 2005 | Journal of Hepatology2005，，4： | 2 |
| 13 | 陶瓷涂层对柴油机性能和排放的影响显示文摘 | Wiese,AD 杜任方 | 1992 | 国外内燃机1992，24，6： | 2 |
| 14 | The response of sulphide and gangue minerals in selected Merensky ores to increased depressant dosages显示文摘 | J. Wiese P. Harris D. Bradshaw | 2007 | Minerals Engineering2007，，10： | 2 |
| 15 | Formation of the sinus node head and differentiation of sinus node myocardium are independently reg- ulated by Tbxl8 and Tbx3显示文摘 | Wiese C Grieskamp T Airik R | 2009 | Circ Res2009，104，3： | 1 |
| 16 | Pathologic evaluation of sentinel lymph nodes in colorectal carcinoma显示文摘 | Wiese D Saha S Badin J | 2000 | Arch Pathol Lab Med2000，124，7： | 1 |
| 17 | A novel hypoxia-response element in the lactate dehydrogen- ase-B gene of the killifish Fundulus heteroclitus 显示文摘 | Rees B B Figueroa Y G Wiese T E | 2009 | Comparative Biochemistry and Physiology A-Molecular Integrative Physiology2009，154，1： | 1 |
| 18 | Molecular staging of early colon cancer on the basis of sentinel node analysis:a multicenter phase Ⅱ trial显示文摘 | Bilchik AJ Saha S Wiese D | 2001 | Clin Oncol2001，19，4： | 1 |
| 19 | Structural organization and differential expression of three stilbene synthase genes located on a 13 kb grapevine DNA fragment显示文摘 | Wilfried Wiese Barbara Vornam Elvira Krause | 1994 | Plant Molecular Biology1994，26，2： | 1 |
| 20 | A recent history of metal accumulation in the sediments of the Thames Estuary,United Kingdom显示文摘 | Wiese S B O Macleod C L Lester J N | 1997 | Estuaries1997，20，3： | 1 |
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