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| 1 | Comparative analysis of ERCP,IDUS,EUS and CT in predicting malignant bile duct strictures显示文摘AIM:To compare endoscopic retrograde cholangio-pancreatography(ERCP),intraductal ultrasound(IDUS),endosonography(EUS),endoscopic transpapillary forceps biopsies(ETP)and computed tomography(CT)with respect to diagnosing malignant bile duct strictures.METHODS:A patient cohort with bile duct strictures of unknown etiology was examined by ERCP and IDUS,ETP,EUS,and CT.The sensitivity,specificity,and accuracy rates of the diagnostic procedures were calculated based on the definite diagnoses proved by histopathology or long-term follow-up in those patients who did not undergo surgery.For each of the diagnostic measures,the sensitivity,specificity,and accuracy rates were calculated.In all cases,the gold standard was the histopathologic staging of specimens or long-term follow-up of at least 12 mo.A comparison of the accuracy rates between the localization of strictures was performed by using the Mann-Whitney U-test and theχ2test as appropriate.A comparison of the accuracy rates between the diagnostic procedures was performed by using the McNemar’s test.Differences were considered statistically significant if P<0.05.RESULTS:A total of 234 patients(127 males,107 females,median age 64,range 20-90 years)with indeterminate bile duct strictures were included.A total of 161patients underwent operative exploration;thus,a surgical histopathological correlation was available for those patients.A total of 113 patients had malignant disease proven by surgery;in 48 patients,benign disease was surgically found.In these patients,the decision for surgical exploration was made due to the suspicion of malignant disease in multimodal diagnostics(ERCP,CT,or EUS).Fifty patients had a benign diagnosis and were followed by a surveillance protocol with a followup of at least 12 mo;the median follow-up was 34 mo.Twenty-three patients had extended malignant disease,and thus were considered palliative.A comparison of the different diagnostic tools for detecting bile duct malignancy resulted in accuracy rates of 91%(ERCP/IDUS),59%(ETP),92%(IDUS+ETP),74%(EUS),and 73%(CT),respectively.In the subgroup analysis,the accuracy rates(%,ERCP+IDUS/ETP/IDUS+ETP;EUS;CT)for each tumor entity were as follows:cholangiocellular carcinoma:92%/74%/92%/70%/79%;pancreatic carcinoma:90%/68%/90%/81%/76%;and ampullary carcinoma:88%/90%/90%/76%/76%.The detection rate of malignancy by ERCP/IDUS was superior to ETP(91%vs 59%,P<0.0001),EUS(91%vs74%,P<0.0001)and CT(91%vs 73%,P<0.0001);EUS was comparable to CT(74%vs 73%,P=0.649).When analyzing accuracy rates with regard to localization of the bile duct stenosis,the accuracy rate of EUS for proximal vs distal stenosis was significantly higher for distal stenosis(79%vs 57%,P<0.0001).CONCLUSION:ERCP/IDUS is superior to EUS and CT in providing accurate diagnoses of bile duct strictures of uncertain etiology.Multimodal diagnostics is recommended. | Hauke S Heinzow Sara Kammerer Carina Rammes Johannes Wessling Dirk Domagk Tobias Meister | 2014 | World Journal of Gastroenterology2014，20，30： | 14 |
| 2 | 树脂填充EVAL纤维吸附剂的制备及其吸附性能表征显示文摘采用具有亲水性的乙烯-乙烯醇共聚物(EVAL)作为纤维吸附剂基质材料,粉末型Lewatit阳离子交换树脂CNP80ws为功能材料,采用可控相分离方法,制备了不同表面形态结构的树脂填充EVAL吸附剂。当使用外部液体调控相分离过程时,在纤维的表面形成了粗糙的开孔结构,并且随树脂的填充量提高纤维表面的粗糙度与开孔度有所提高。研究结果表明:树脂填充EVAL纤维吸附剂具有较大的吸附容量与较高的脱附率,其吸附容量不低于53.9mgBSA/g吸附剂(树脂填充量50%)。 | 张玉忠 李然 李泓 肖长发 Zandrie Borneman Geert-Henk Koops Matthias Wessling | 2005 | 离子交换与吸附2005，21，3： | 4 |
| 3 | Investigating the Synthesis of RBF Networks显示文摘InvestigatingtheSynthesisofRBFNetworks￥V.DavidSanchezA.(GermanAerospaceResearchEstablishment,DLROberpfaffenhofenInstituteforR... | V. David Sanchez A.(German Aerospace Research Establishment, DLR OberpfaffenhofenInstitute for Robottes and System DynamicsD-82230 Wessling, Germany) | 1996 | Journal of Systems Engineering and Electronics1996，7，3： | 2 |
| 4 | Anion exchange membranes for alkaline fuel cells: A review显示文摘 | Géraldine Merle Matthias Wessling Kitty Nijmeijer | 2011 | Journal of Membrane Science2011，，1： | 2 |
| 5 | 树脂填充聚醚砜纤维吸附剂对牛血清蛋白吸附性能的研究显示文摘重点研究树脂填充聚醚砜(PES)纤维吸附剂与模型蛋白质牛血清蛋白(BSA)之间的吸附与脱附行为.结果表明,蛋白质BSA在树脂填充PES纤维吸附剂中的平衡吸附过程较好地符合朗格缪尔吸附模型,树脂Lewatit CNP80ws填充PES吸附剂的最大吸附容量约为139mg BSA/g吸附剂.表面具有开孔结构的树脂填充PES纤维吸附剂的吸附速率较快,在不同结构纤维吸附剂中BSA的扩散系数在1.82×10^-14~8.7×10^-14m^2/s范围内变化.另外,考察了BSA溶液的pH与洗脱剂等因素对吸附剂吸附与脱附性能的影响,研究结果对蛋白质的实际分离纯化具有重要的参考价值. | 张玉忠 Borneman Z Koops G-H Wessling M | 2006 | 高分子学报2006，16，2： | 1 |
| 6 | detection of colorectal polyps:comparison of multi-detector row CT and MR colonography in a colon phantom显示文摘 | Wessling J Fishbach R Borchert A | 2006 | Radiology2006，241，1： | 1 |
| 7 | Characterization of poly(p-phenylene-cis-benzobisoxazole) in methanesulfonic acid 显示文摘 | Roitman D B Wessling R A | 1993 | Macromolecules1993，26，19： | 1 |
| 8 | Passivation of metals by coating with polyani- line:Corrosion potential shift and morphological changes 显示文摘 | WESSLING B | 1994 | Advanced Materials1994，6，3： | 1 |
| 9 | Transforming biogas into biomethane using membrane technology显示文摘 | Scholz M Melin T Wessling M | 2013 | Renewable & Sustainable Energy Reviews2013，17，： | 1 |
| 10 | Corrosion Protection of Mild Steel by Coatings Containing Polyaniline 显示文摘 | Lu W K Elsenbaumer R L Wessling B | 1995 | Synthetic Metal1995，71，： | 1 |
| 11 | Corrosion protection of mild steel by coatings containing polyaniline显示文摘 | Lu W K Elsenbaumer R L Wessling B | 1995 | Synthetic Metal1995，71，： | 1 |
| 12 | Use of twist-drill craniostomy with drain in evacuation of chronic subdural hematomas:independent predictors of recurrence 显示文摘 | Escosa Ba6 M Wessling H Salca HC | 2011 | Acta Neurochir(Wien)2011，153，5： | 1 |
| 13 | 显示文摘 | MERLEG WESSLING M NIJMEIJER K | 2011 | J Membrane Science2011，37，12： | 1 |
| 14 | Nutrient removal by NF and RO membranes in a decentralized sanitation system 显示文摘 | Ellen Mvan Voorthuizen Arie Zwijnenburg Matthias Wessling | 2005 | Water Res2005，39，15： | 1 |
| 15 | Corrosion Protection of Iron by Polypyrrole Coatings Containing Polyaniline 显示文摘 | Lu W K Elsenbaumer R L Wessling B | 1995 | Synthetic Metals1995，71，13： | 1 |
| 16 | Comparison of dose standard units for drug utilization studies显示文摘 | Merlo J Wessling A Melander A | 1996 | Eur J Clin pharmacol1996，50，12： | 1 |
| 17 | The thermal decomposition ofpoly(vinylidene chloride)in the solid state显示文摘 | R D Bohme R A Wessling | 1972 | Journal ofApplied Polymer Science1972，16，： | 1 |
| 18 | Colorectal polyps: detection with multi-slice CT colonography显示文摘 | Wessling J Fischbach R Domagk D | 2001 | Rofo Fortschr Geb Rontgenstr Neuen Bildgeb Verfahr2001，173，12： | 1 |
| 19 | Protonation of CIS-PBO in metanesulfonic acid solutions显示文摘 | Daniel B Roitman Jan McAlister Marc McAdon Ritchie A Wessling | 1994 | Journal of Polymer Science Part B:Polymer Physics1994，7，32： | 1 |
| 20 | Passivation of Metals by Coating with Polyani-line: Corrossion Potential Shift and Morphological Changes 显示文摘 | WESSLING B | 1994 | Advanced Materals1994，6，： | 1 |
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