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| 1 | Schistosoma mansoni proteins attenuate gastrointestinal motility disturbances during experimental colitis in mice显示文摘AIM:To investigate the therapeutic effect of Schistosoma mansoni(S.mansoni) soluble worm proteins on gastrointestinal motility disturbances during experimental colitis in mice. METHODS:Colitis was induced by intrarectal injection of trinitrobenzene sulphate(TNBS) and 6 h later,mice were treated ip with S.mansoni proteins.Experiments were performed 5 d after TNBS injection.Inflammationwas quantified using validated inflammation parameters. Gastric emptying and geometric center were measured to assess in vivo gastrointestinal motility.Peristaltic activity of distal colonic segments was studied in vitro using a modified Trendelenburg set-up.Cytokine profiles of T-lymphocytes isolated from the colon were determined by real time reverse transcriptase-polymerase chain reaction. RESULTS:Intracolonic injection of TNBS caused severe colitis.Treatment with S.mansoni proteins significantly ameliorated colonic inflammation after 5 d.TNBS did not affect gastric emptying but significantly decreased the geometric center and impaired colonic peristaltic activity 5 d after the induction of colitis.Treatment with S.mansoni proteins ameliorated these in vivo and in vitro motility disturbances.In addition,TNBS injection caused a downregulation of effector T cell cytokines after 5 d,whereas a S.mansoni protein effect was no longer observed at this time point. CONCLUSION:Treatment with S.mansoni proteins attenuated intestinal inflammation and ameliorated motility disturbances during murine experimental colitis. | Nathalie E Ruyssers Benedicte Y De Winter Joris G De Man Natacha D Ruyssers Ann J Van Gils Alex Loukas Mark S Pearson Joel V Weinstock Paul A Pelckmans Tom G Moreels | 2010 | World Journal of Gastroenterology2010，16，6： | 11 |
| 2 | 心血管疾病病死率与血清25-羟基维生素D浓度相关性研究显示文摘目的研究心衰死亡、心血管疾病死亡和过早死亡与血清25-羟基维生素D[25(OH)D]浓度的相关性。方法在第3次美国健康和营养调查中,1988~1994年为基线数据,纳入35岁以上参与者13 131名(男性6130名,女性7 001名),随访至2000年12月31日。结果随访8年期间,共有3 266人死亡(24.9%),其中心衰死亡101人,心血管疾病死亡1 451人,早死1 066人。心衰死亡者中有37%血清25(OH)D水平低于20ng/mL,非心衰死亡者为26%(P<0.001)。多元Cox模型显示,血清25(OH)D水平低于20ng/mL的心衰死亡风险是超过30ng/mL的2.06倍(95%CI:1.01~4.25)(P<0.001),过早死亡风险为1.40倍(95%CI:1.17~1.68;P<0.001);血清25(OH)D浓度20~29ng/mL的过早死亡风险是超过30ng/mL的1.11倍(95%CI:0.93~1.33)。结论血清25(OH)D水平不足的成年人死于心血管病、心衰和过早死亡的风险较高。 | 刘隆健 魏敏 陈明 Shelley R Hankins Ana E.Nùez Robert A Watson Perry J Weinstock Craig J.Newschaffer Howard J Eisen 邹强 杨书 陈卫中 | 2013 | 成都医学院学报2013，8，2： | 6 |
| 3 | Complications and cost associated with parenteral nutrition delivered to hospitalized patients through either subclavian or peripherally-inserted central catheters显示文摘 | C.T. COWL J.V. WEINSTOCK A. AL-JURF K. EPHGRAVE J.A. MURRAY K. DILLON | 2000 | Clinical Nutrition2000，，4： | 3 |
| 4 | Randomised clinical trial: the safety and tolerability of T richuris suis ova in patients with Crohn’s disease显示文摘 | W. J. Sandborn D. E. Elliott J. Weinstock R. W. Summers A. Landry‐Wheeler N. Silver M. D. Harnett S. B. Hanauer | 2013 | Aliment Pharmacol Ther2013，，3： | 2 |
| 5 | Where are we on worms?显示文摘 | David E. Elliott Joel V. Weinstock | 2012 | Current Opinion in Gastroenterology2012，，6： | 2 |
| 6 | Translatability of helminth therapy in inflammatory bowel diseases显示文摘 | Joel V. Weinstock David E. Elliott | 2012 | International Journal for Parasitology2012，，： | 2 |
| 7 | Evaluating the Management Journals:A Second Look显示文摘 | WEINSTOCK I | 1984 | Academy of Management Journal1984，27，3： | 1 |
| 8 | Keratinocyte carcinoma显示文摘 | Albert MR Weinstock MA | 2003 | CA Cancer J Clin2003，53，： | 1 |
| 9 | Peritoneal implants of o- varian serous borderline tumors: histologie features and prognosis 显示文摘 | Bell D A Weinstock M A Scully R E | 1988 | Cancer1988，62，10： | 1 |
| 10 | Structural reorganization of alpha-synuclein at low pH observed by NMR and REMD simulations显示文摘 | Wu K P Weinstock D S Narayanan C | 2009 | J Mol Biol2009，391，4： | 1 |
| 11 | Nonmelanoma skin cancer in the United States:incidence显示文摘 | Miller DL Weinstock MA | 1994 | J Am Acad Dermatol1994，30，： | 1 |
| 12 | Insights into social insects from the genome of the honeybee Apis mellifera 显示文摘 | WEINSTOCK G M ROBINSON G E GIBBS R A | 2006 | Nature2006，443，： | 1 |
| 13 | Effects of Enterococcus faecalis for genes on production of gelatinase and a serine protease and virulence显示文摘 | Qin X Singh K V Weinstock G M | 2000 | Infect Immun2000，68，5： | 1 |
| 14 | Malignant melanoma of the vulva and vagina in the United States: patterns of incidence and population-based estimates of survival显示文摘 | Martin A Weinstock MD | 1994 | Am J Obstet Gynecol1994，171，12： | 1 |
| 15 | Epidemiology and prognosis of anorectal melanoma 显示文摘 | Weinstock MA | 1993 | Gastroenterology1993，104，1： | 1 |
| 16 | Study of mitoxantrone for the treatment of recurrent neuromyelitis optica (Devic's disease) 显示文摘 | Weinstock GB Ramanathan M Lincoff N | 2006 | Arch Neuro12006，63，7： | 1 |
| 17 | Outcome of infe-rior oblique recession with or without vertical rectus re-cession for unilateral superior oblique paresis 显示文摘 | Morad Y Weinstock V M Kraft S P | 2001 | Bin-ocul Vis Strabismus Q2001，16，1： | 1 |
| 18 | Neuroticism as a common feature of the depressive and anxiety disorders: a test of the re- vised integrative hierarchical model in a national sample 显示文摘 | WEINSTOCK LM WHISMAN MA | 2006 | J Abnorm Psychol2006，115，1： | 1 |
| 19 | 显示文摘 | Weinstock DM Feinstein MB Sepkowitz KA | 2003 | Bone Marrow Transplant2003，31，： | 1 |
| 20 | Epidemiology and prognosis of anorectal melanoma 显示文摘 | | 1993 | Gastroenterology1993，104，1： | 1 |
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