| 4 | MEF promotes stemness in the pathogenesis of gliomas显示文摘High-grade gliomas are aggressive and uniformly fatal tumors,composed of a heterogeneous population of cells that include many with stem-cell-like properties.The acquisition of stem-like traits might contribute to glioma initiation,growth,and recurrence.Here we investigated the role of the transcription factor myeloid Elf-1 like factor(MEF,also known as ELF4) in gliomas.We found that MEF is highly expressed in both human and mouse glioblastomas and its absence impairs gliomagenesis in a PDGF-driven glioma mouse model.We show that modulation of MEF levels in both mouse neural stem cells and human glioblastoma cells has a significant impact on neurosphere formation.Moreover,we identify Sox2 as a direct downstream target of MEF.Taken together,our studies implicate MEF as a previously unrecognized gatekeeper gene in gliomagenesis that promotes stem cell characteristics through Sox2 activation. | Bazzoli E Pulvirenti T Oberstadt MC Perna F Wee B Schultz N Huse JT Fomchenko EI Voza F Tabar V Brennan CW DeAngelis LM Nimer SD Holland EC Squatrito M | 2013 | 中国神经肿瘤杂志2013，11，1： | 0 |
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