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| 1 | Schizophrenia 显示文摘 | Schultz S Andreasen N | 1999 | Lancet1999，353，： | 2 |
| 2 | How should liver hypertrophy be stimulated?A comparison of upfront associating liver partition and portal vein ligation for staged hepatectomy(ALPPS)and portal vein embolization(PVE)with rescue possibility显示文摘Background:The role of associating liver partition and portal vein ligation for staged hepatectomy(ALPPS)in comparison to portal vein embolization(PVE)is debated.The aim of this study was to compare successful resection rates(RR)with upfront ALPPS vs.PVE with rescue ALPPS on demand and to compare the hypertrophy of the liver between ALPPS and PVE plus subsequent rescue ALPPS.Methods:A retrospective analysis of all patients treated with PVE for colorectal liver metastasis(CRLM)or ALPPS(any diagnosis,rescue ALPPS included)at five Scandinavian university hospitals during the years 2013-2016 was conducted.A Chi-square test and a Mann-Whitney U test were used to assess the difference between the groups.A successful RR was defined as liver resection without a 90-day mortality.Results:A total of 189 patients were included.Successful RR was in 84.5%of the patients with ALPPS upfront and in 73.3%of the patients with PVE and rescue ALPPS on demand(P=0.080).The hypertrophy of the future liver remnants(FLRs)with ALPPS upfront was 71%(48-97%)compared to 96%(82-113%)after PVE and rescue ALPPS(P=0.010).Conclusions:Upfront ALPPS offers a somewhat higher successful RR than PVE with rescue ALPPS on demand.The sequential combination of PVE and ALPPS leads to a higher overall degree of hypertrophy than upfront ALPPS. | Ernesto Sparrelid Kristina Hasselgren Bård Ingvald Røsok Peter Nørgaard Larsen Nicolai Aagaard Schultz Ulrik Carling Eva Fallentin Stefan Gilg Per Sandström Gert Lindell Bergthor Björnsson | 2021 | Hepatobiliary Surgery and Nutrition2021，10，1： | 2 |
| 3 | 星形胶质细胞转录组分析指导的脑卒中靶标鉴定显示文摘星形胶质细胞支持正常的脑功能,但在卒中等病理条件下,星形胶质细胞反应性激活,其也可能参与神经退行性改变。反应性星形胶质细胞增生对机体有益或有害,与环境背景有关,但其分子基础仍未得到充分解释。借助RiboTag技术,我们在特异性地短暂性大脑中动脉闭塞(tMCAO)72h后的小鼠星形胶质细胞中,纯化翻译mRNA,构建卒中特异性星形胶质细胞翻译组数据库。我们发现,与对照组脑组织相比,tMCAO后的反应性星形胶质细胞显示与A2表型相关的转录物的富集,这与神经保护相关。星形胶质细胞也会上调大量潜在的神经毒性基因。我们共鉴定了1003个基因和38个转录因子的差异表达,其中Stat3,Sp1和Spi1变化最明显。为了进一步探索Stat3介导的通路对卒中发病机制的影响,我们选择星形胶质细胞特异性条件性缺失Stat3的小鼠制造tMCAO模型,发现这些小鼠的局灶性缺血卒中体积减少,且梗死72h后小鼠的运动结果改善。综上所述,本研究扩展了新兴的星形胶质细胞特异性靶向卒中治疗数据库,并肯定了星形胶质细胞是脑功能的关键保障细胞。 | Rakers C Schleif M Blank N Matu?ková H Ulas T H?ndler K Torres SV Schumacher T Tai K Schultze JL Jackson WS Petzold GC 聂昊 | 2019 | 神经损伤与功能重建2019，14，6： | 2 |
| 4 | Yolk sac ab- sorption and initiation of growth m broilers显示文摘 | Chamblee T N Brake J D Schultz C D | 1992 | Poul Sci1992，71，： | 1 |
| 5 | EEG - adjus- ted target - controlled infusion: Propofol target concentration with different doses of remifentanil 显示文摘 | BUTTNER N SCHULTZ B GROUVEN U | 2010 | Anaesthesist2010，59，： | 1 |
| 6 | Defining the spermatogonial stem cell显示文摘 | Hamra FK Schultz N Chapman KM | 2004 | Dev Biol2004，269，2： | 1 |
| 7 | Neural mecha-nisms of observational learning显示文摘 | Burke C J Tobler P N Baddeley M Schultz W | 2010 | Proc Natl Acad Sci USA2010，107，14： | 1 |
| 8 | Integrative genomic profi- ling of human prostate cancer 显示文摘 | Taylor BS Schultz N Hieronymus H | 2010 | Cancer Cell2010，18，1： | 1 |
| 9 | Identification of a new class of small molecules that efficiently reactivate latent Epstein - Barr virus显示文摘 | Tikhmyanova N Schultz D C Lee T | 2014 | ACS chemical biology2014，9，3： | 1 |
| 10 | Pterygia pathogenesis: corneal invasion by matrix metalloproteinase expressing altered limbal epithelial basal cells显示文摘 | Dushku N John MK Schultz GS | 2001 | Arch Ophthalrnol2001，119，5： | 1 |
| 11 | Headache and major depression: Is association specific to migraine显示文摘 | Breslau N Schultz LR Stewart WF | 2000 | Neurology2000，54，2： | 1 |
| 12 | ZrNbCuNiAI bulk metallic glass matrix composites containing dendritic bcc phase precipitates显示文摘 | KUHN LJ ECKERT J MATTERN N SCHULTZ L | 2002 | Appl Phys Lett2002，80，： | 1 |
| 13 | Development and mapping of SSR markers for maize显示文摘 | SHAROPOVA N MCMULLEN M D SCHULTZ L | 2002 | Plant Mol Biol2002，48，： | 1 |
| 14 | Expression of MSY2 in mouse oocytes and preimplantation embryos 显示文摘 | Yu J Hecht N B Schultz R M | 2001 | Biology of Reproduction2001，65，4： | 1 |
| 15 | Increased expression of androgen receptor(AR) and enzymes in- volved in androgen synthesis in metastatic prostate cancer- Targets for novel personalized therapies显示文摘 | Mitsiades N Schultz N Taylor B S | 2009 | J Clin Oncol [45th Annu Meet Am Soc Clin Oncol (AS- CO) (May 29 June 2 Orlando) 200912009，27，15： | 1 |
| 16 | Growth factors and wonnd hesling:biochemical properties of growth factors and their receptors显示文摘 | BENNETT N T SCHULTZ GS GAINESVILLE | | The Amercan Journal of Surgery0，165，1： | 1 |
| 17 | GMRES:A generalized minimal residual algorithm for solving nonsymmetric linear systems显示文摘 | Schultz M N | 1986 | SI-AM journal of Science and Statistical Computing1986，7，3： | 1 |
| 18 | Pterygia pathogenesis:corneal invasion by matrix metalloproteinase expressing altered limbal epithelial basal cells显示文摘 | Dushku N John MK Schultz GS Reid TW | 2001 | Arch Ophthalmol2001，119，5： | 1 |
| 19 | Central nervous system diseases in patientswith systemic lupus erythematosus 显示文摘 | Futrell N Schultz LR Millikan C | 1992 | Neurology1992，42，11： | 1 |
| 20 | Headache types and panic disorder:directionality and specificity显示文摘 | Breslau N Schultz LR Stewart WF | 2001 | Neurology2001，56，3： | 1 |
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