|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Long-term outcome and prognostic factors of patients with hilar cholangiocarcinoma显示文摘AIM: To evaluate the long-term outcome and prognostic factors of patients with hilar cholangiocarinoma. METHODS: Ninety-six consecutive patients underwent treatment for malignant hilar bile duct tumors during 1995–2005. Of the 96 patients, 20 were initially treated with surgery (n = 2 R0 / n = 18 R1). In non-operated patients, data analysis was performed retrospectively. RESULTS: Among the 96 patients, 76 were treated with endoscopic transpapillary (ERC, n = 45) and/or percutaneous transhepatic biliary drainage (PTBD, n = 31). The mean survival time of these 76 patients undergoing palliative endoscopic and/or percutaneous drainage was 359 ± 296 d. The mean survival time of patients with initial bilirubin levels > 10 mg/dL was significantly lower (P < 0.001) than patients with bilirubin levels < 10 mg/dL. The mean survival time of patients with Bismuth stage Ⅱ (n = 8), Ⅲ (n = 28) and Ⅳ (n = 40) was 496 ± 300 d, 441 ± 385 d and 274 ± 218 d, respectively. Thus, patients with advanced Bismuth stage showed a reduced mean survival time, but the difference was not significant. The type of biliary drainage had no significant beneficial effect on the mean survival time (ERC vs PTBD, P = 0.806). CONCLUSION: Initial bilirubin level is a significant prognostic factor for survival of patients. In contrast, age, tumor stage according to the Bismuth-Corlette classification, and types of intervention are not significant prognostic parameters for survival. Palliative treatment with endoscopic or percutaneous biliary drainage is still suboptimal, new diagnostic and therapeutic tools need to be evaluated. | Andreas Weber Sonja Landrock Jochen Schneider Manfred Stangl Bruno Neu Peter Born Meinhard Classen Thomas Rsch Roland M Schmid Christian Prinz | 2007 | World Journal of Gastroenterology2007，13，9： | 23 |
| 2 | 气溶胶OCEC切割点确定方法改进及应用显示文摘用MOUDI采样器分级(0.18~18μm,8级)采集北京(BD)及美国亚特兰大(GT)2011年7、8月大气气溶胶样品,测定有机碳(OC)及元素碳(EC).结果表明,由于石英膜结构在灼烧过程中变化,空白膜激光值在OCEC分析过程会随温度改变而变化,且整体呈下降趋势,扣除空白膜激光值变化后手动确定切割点,即激光校正切割可以提高切割点准确性.采用激光校正切割法得到的OC、EC浓度及粒径分布与有氧无氧切割法不同.一些样品切割点出现在通氧前,原因可能是气溶胶中金属等可在无氧环境中催化氧化EC或受热后分解、变色的吸光物质含量较高等.GT气溶胶碳质组分浓度低于BD,且除GT采样点EC外,均呈双峰分布.BD及GT两个采样点OC浓度在0.56~1.0μm、3.2~5.6μm两个粒径段出现峰值,采样期间BD峰值浓度分别为(2.82±1.59)μg.m-3、(1.95±0.76)μg.m-3,GT峰值浓度分别为(1.28±0.41)μg.m-3、(0.64±0.19)μg.m-3.BD采样点EC浓度峰值出现在1.0~1.8μm、3.2~5.6μm,分别为(0.32±0.24)μg.m-3、(0.26±0.19)μg.m-3.GT采样点EC呈三峰分布,集中于粒径更小的气溶胶中,粒径为0.18~0.56μm气溶胶中EC含量占总采样粒径段44.6%.GT采样点OC、EC浓度均较BD更集中于积聚模态,原因可能为夏季GT主要污染源是机动车尾气排放,而BD存在较多工业活动等排放. | 王莉华 董华斌 闫才青 曾立民 郑玫 张延君 刘久萌 Weber R J | 2012 | 环境科学2012，33，9： | 6 |
| 3 | Correlation of endoscopic disease severity with pediatric ulcerative colitis activity index score in children and young adults with ulcerative colitis显示文摘AIM To investigate of pediatric ulcerative colitis activity index(PUCAI) in ulcerative colitis correlate with mucosal inflammation and endoscopic assessment of disease activity(Mayo endoscopic score).METHODS We reviewed charts from ulcerative colitis patients who had undergone both colonoscopy over 3 years. Clinical assessment of disease severity within 35 d(either before or after) the colonoscopy were included. Patients were excluded if they had significant therapeutic interventions(such as the start of corticosteroids or immunosuppressive agents) between the colonoscopy and the clinical assessment. Mayoendoscopic score of the rectum and sigmoid were done by two gastroenterologists. Inter-observer variability in Mayo score was assessed.RESULTS We identified 99 patients(53% female, 74% pancolitis) that met inclusion criteria. The indications for colonoscopy included ongoing disease activity(62%), consideration of medication change(10%), assessment of medication efficacy(14%), and cancer screening(14%). Based on PUCAI scores, 33% of patients were in remission, 39% had mild disease, 23% had moderate disease, and 4% had severe disease. There was 'moderate-substantial' agreement between the two reviewers in assessing rectal Mayo scores(kappa = 0.54, 95%CI: 0.41-0.68). CONCLUSION Endoscopic disease severity(Mayo score) assessed by reviewing photographs of pediatric colonoscopy has moderate inter-rater reliability, and agreement was less robust in assessing patients with mild disease activity. Endoscopic disease severity generally correlates with clinical disease severity as measured by PUCAI score. However, children with inflamed colons can have significant variation in their reported clinical symptoms. Thus, assessment of both clinical symptoms and endoscopic disease severity may be required in future clinical studies. | Basavaraj Kerur Heather J Litman Julia Bender Stern Sarah Weber Jenifer R Lightdale Paul A Rufo Athos Bousvaros | 2017 | World Journal of Gastroenterology2017，23，18： | 5 |
| 4 | Bcl-x_L and Myeloid cell leukaemia-1 contribute to apoptosis resistance of colorectal cancer cells显示文摘AIM: To explore the role of Bcl-xL and Myeloid cell leukaemia (Mcl)-1 for the apoptosis resistance of colorectal carcinoma (CRC) cells towards current treat-ment modalities. METHODS: Bcl-xL and Mcl-1 mRNA and protein ex-pression were analyzed in CRC cell lines as well as human CRC tissue by Western blot,quantitative PCRand immunohistochemistry. Bcl-xL and Mcl-1 protein expression was knocked down or increased in CRC cell lines by applying specific siRNAs or expression plas-mids,respectively. After modulation of protein expres-sion,CRC cells were treated with chemotherapeutic agents,an antagonistic epidermal growth factor recep-tor (EGFR1) antibody,an EGFR1 tyrosine kinase inhibi-tor,or with the death receptor ligand TRAIL. Apoptosis induction and cell viability were analyzed. RESULTS: Here we show that in human CRC tis-sue and various CRC cell lines both Bcl-xL and Mcl-1 are expressed. Bcl-xL expression was higher in CRC tissue than in surrounding non-malignant tissue,both on protein and mRNA level. Mcl-1 mRNA expression was significantly lower in ma-lignant tissues. However,protein expression was slightly higher. Viability rates of CRC cells were significantly decreased after knock down of Bcl-xL expression,and,to a lower extent,after knock down of Mcl-1 expression. Furthermore,cells with reduced Bcl-xL or Mcl-1 expression was more sensitive towards oxaliplatin-and irinotecan-induced apoptosis,and in the case of Bcl-xL also towards 5-FU-induced apoptosis. On the other hand,upregulation of Bcl-xL by transfec-tion of an expression plasmid decreased chemothera-peutic drug-induced apoptosis. EGF treatment clearly induced Bcl-xL and Mcl-1 expression in CRC cells. Apop-tosis induction upon EGFR1 blockage by cetuximab or PD168393 was increased by inhibiting Mcl-1 and Bcl-xL expression. More strikingly,CD95-and TRAIL-induced apoptosis was increased by Bcl-xL knock down. CONCLUSION: Our data suggest that Bcl-xL and,to a lower extent,Mcl-1,are important anti-apoptotic factors in CRC. Specific downregulation of Bcl-xL is a promising approach to sensitize CRC cells towards chemotherapy and targeted therapy. | Henning Schulze-Bergkamen Roland Ehrenberg Lothar Hickmann Binje Vick Toni Urbanik Christoph C Schimanski Martin R Berger Arno Schad Achim Weber Steffen Heeger Peter R Galle Markus Moehler | 2008 | World Journal of Gastroenterology2008，14，24： | 4 |
| 5 | 热应激和低营养摄入对猪肠道完整性和功能的影响显示文摘热应激会损害肠道完整性,并诱发肠渗漏。因此,本试验研究了直接或间接热应激(通过减少采食量)对生长猪肠道通透性的影响。选用体重(43±4)kg的杂交后备母猪(n=48),分别安置在以下控制环境中:热中性(TN)环境(20℃,湿度35%~50%,自由采食)、热应激(HS)环境(35℃,湿度20%~35%,自由采食)、热中性环境配对饲喂(PFTN,以消除不同采食量的交互影响)。第1、3、7天使猪只安乐死,采集的空肠样品被安装到尤式灌流室,测定跨膜电阻抗值(TER)和异硫氰基荧光标记的脂多糖(LPS)渗透性(APP,表示为表观渗透系数)。此外,评估肠道完整性以及应激基因和蛋白标志物。结果表明,不考虑热应激天数,HS组与TN组猪相比,血浆内毒素水平增加45%(P〈0.05),空肠TER降低30%(P〈0.05),LPS渗透率增加2倍(P〈0.01)。此外,与PFTN组相比,HS组第7天的猪LPS渗透性有增加的趋势(P=0.06)。整个试验阶段HS组溶菌酶和碱性磷酸酶活性下降,分别下降46%和59%(P〈0.05);然而,3 d和7 d空肠免疫细胞标记物——髓过氧化物酶活性增加(P〈0.05)。由此可见,热应激和减少采食量都会降低肠道完整性,并增加内毒素渗透性。推测这可能会导致炎症加重,在炎热的夏季可能是导致猪生长性能降低的原因。 | Pearce S C Mani V Weber T E Rhoads R P Patience J F Baumgard L H Gabler N K | 2016 | 中国饲料2016，，3： | 3 |
| 6 | 24h动态中心动脉收缩压和左心室质量的关系:一项前瞻性多中心研究显示文摘研究者在7个欧洲中心中调查左心室质量与肱动脉诊室血压以及肱动脉压和中心动脉动态收缩压之间的关系。使用校准的示波装置测量,经平均压/舒张压校准和转换函数计算中心动脉收缩压。由不知道血压值的单个操作者通过M型超声心动图测定左心室质量。研究者调查了未使用抗高血压药物的受试者289人(女性137人,平均年龄50.8岁)。 | 黄洁 叶鹏 Weber T Wassertheurer S Schmidt-Trucks?ss A Rodilla E Ablasser C Jankowski P Lorenza Muiesan M Giannattasio C Mang C Wilkinson I Kellermair J Hametner B Pascual JM Zweiker R Czarnecka D Paini A Salvetti M Maloberti A McEniery C | 2017 | 中华高血压杂志2017，25，11： | 2 |
| 7 | Measurement of excited-state-absorption loss for Ce^3+ in Y3Al5O12 and implications for tunable 5d→4f rare earth laser显示文摘 | Jacobs R R Krupke W F Weber M | 1978 | J Appl Phys Lett(S0003-6951)1978，，33： | 1 |
| 8 | Formation of low molecular weight carbonyl compounds by sensitized photochemical decomposition of aliphatic hydro-carbon in seawater 显示文摘 | EHRHARDT M G WEBER R R | 1991 | Frsenirus J Anal Chem1991，339，： | 1 |
| 9 | Photopoly-met8 for holography显示文摘 | Smothers W K Monroe R M Weber A M | 1990 | SPIE1990，1212，： | 1 |
| 10 | Seed yield losses from lodging combine harvesting in soybeans 显示文摘 | Weber C R Fehr W R | 1966 | Agronomy Journal1966，58，： | 1 |
| 11 | Evaluation of the effects of total sleep deprivation on cerebral blood flow using single photo emission computerized tomography 显示文摘 | Volk SA Kaendler SH Weber R | 1992 | Acta Psychiatr Scand1992，86，3： | 1 |
| 12 | Effective Bandwidths for Stationary Source显示文摘 | Weber R | 1995 | Probability in Engineering and Informational Sceinces1995，9，2： | 1 |
| 13 | Muhirod resonators for high-power solid-state lasers with improved beam quality 显示文摘 | Driedger K P Ifflander R M Weber H | 1988 | IEEE J Quantum Electron1988，24，4： | 1 |
| 14 | Internet of things - Need for a new legal environment 显示文摘 | Weber R H | 2009 | Computer Law and Security Report2009，25，6： | 1 |
| 15 | Changing patterns of practice in the management of nasopharynx carcinoma ( NPC ) : analysis of the National Cancer Database ( NCDB ) 显示文摘 | Hoffman H Cooper JS Weber R | 2004 | J Clin Oncol2004，22，5： | 1 |
| 16 | Mosaic genes and mosaic chromosomes: intra - and interspecies genomic variation of Streptococcus pneumoniae显示文摘 | Hakenbeck R Balmelle N Weber B | 2001 | Infect Immun2001，69，4： | 1 |
| 17 | Glucose induce beta-cell apoptosis via upregulation of the Fas receptor in human islets显示文摘 | Maedler K Spinas GA Lehmann R Sergeev P Weber M Fontana A | 2001 | Diabetes2001，50，8： | 1 |
| 18 | Vendor Selection Criteria and Methods显示文摘 | Weber C A Current J R Benton W C | 1991 | European Journal of Operational Research1991，50，： | 1 |
| 19 | Zeigerwerte Von Pflanzen in Mitteleuropa显示文摘 | EUenberg H Weber H E Dull R | 1991 | Scripta Geobotanica1991，18，： | 1 |
| 20 | Endothelial progenitor cells mo- bilization, differentiation, and homing 显示文摘 | Hristov M Erl R Weber PC | 2003 | Arterioscler Thromb Vasc Biol2003，23，7： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员