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| 1 | Passive expansion of sub-maximally dilated transjugular intrahepatic portosystemic shunts and assessment of clinical outcomes显示文摘AIM To assess for passive expansion of sub-maximally dilated transjugular intrahepatic portosystemic shunts(TIPS) and compare outcomes with maximally dilated TIPS.METHODS Polytetrafluoroethylene covered TIPS(Viatorr) from July 2002 to December 2013 were retrospectively reviewed at two hospitals in a single institution. Two hundred and thirty patients had TIPS maximally dilated to 10 mm(m TIPS), while 43 patients who were at increased risk for hepatic encephalopathy(HE), based on clinical evaluation or low pre-TIPS portosystemic gradient(PSG), had 10 mm TIPS sub-maximally dilated to 8 mm(sm TIPS). Group characteristics(age, gender, Model for End-Stage Liver Disease score, post-TIPS PSG and clinical outcomes were compared between groups, including clinical success(ascites or varices), primary patency,primary assisted patency, and severe post-TIPS HE. A subset of fourteen patients with sm TIPS underwent follow-up computed tomography imaging after TIPS creation, and were grouped based on time of imaging(< 6 mo and > 6 mo). Change in diameter and crosssectional area were measured with 3D imaging software to evaluate for passive expansion.RESULTS Patient characteristics were similar between the sm TIPS and m TIPS groups, except for pre-TIPS portosystemic gradient, which was lower in the sm TIPS group(19.4 mm Hg ± 6.8 vs 22.4 mm Hg ± 7.1, P = 0.01). Primary patency and primary assisted patency between sm TIPS and m TIPS was not significantly different(P = 0.64 and 0.55, respectively). Four of the 55 patients(7%) with sm TIPS required TIPS reduction for severe refractory HE, while this occurred in 6 of the 218 patients(3%) with m TIPS(P = 0.12). For the 14 patients with follow-up computed tomography(CT) imaging, the median imaging follow-up was 373 d. There was an increase in median TIPS diameter, median percent diameter change, median area, and median percent area change in patients with CT follow-up greater than 6 mo after TIPS placement compared to follow-up within 6 mo(8.45 mm, 5.58%, 56.04 mm^2, and 11.48%, respectively, P = 0.01).CONCLUSION Passive expansion of sm TIPS does occur but clinical outcomes of sm TIPS and m TIPS were similar. Sub-maximal dilation can prevent complications related to overshunting in select patients. | Michael C Hsu Charles N Weber S William Stavropoulos Timothy W Clark Scott O Trerotola Richard D Shlansky Goldberg Michael C Soulen Gregory J Nadolski | 2017 | World Journal of Hepatology2017，9，12： | 11 |
| 2 | Relationship between Th17 immune response and cancer显示文摘Cancer is the second leading cause of death worldwide and epidemiological projections predict growing cancer mortality rates in the next decades.Cancer has a close relationship with the immune system and,although Th17 cells are known to play roles in the immune response against microorganisms and in autoimmunity,studies have emphasized their roles in cancer pathogenesis.The Th17 immune response profile is involved in several types of cancer including urogenital,respiratory,gastrointestinal,and skin cancers.This type of immune response exerts pro and antitumor functions through several mechanisms,depending on the context of each tumor,including the protumor angiogenesis and exhaustion of T cells and the antitumor recruitment of T cells and neutrophils to the tumor microenvironment.Among other factors,the paradoxical behavior of Th17 cells in this setting has been attributed to its plasticity potential,which makes possible their conversion into other types of T cells such as Th17/Treg and Th17/Th1 cells.Interleukin(IL)-17 stands out among Th17-related cytokines since it modulates pathways and interacts with other cell profiles in the tumor microenvironment,which allow Th17 cells to prevail in tumors.Moreover,the IL-17 is able to mediate pro and antitumor processes that influence the development and progression of various cancers,being associated with variable clinical outcomes.The understanding of the relationship between the Th17 immune response and cancer as well as the singularities of carcinogenic processes in each type of tumor is crucial for the identification of new therapeutic targets. | Hanna Santos Marques Breno Bittencourt de Brito Filipe Antônio França da Silva Maria Luísa Cordeiro Santos Júlio César Braga de Souza Thiago Macêdo Lopes Correia Luana Weber Lopes Nayara Silva de Macêdo Neres Rafael Santos Dantas Miranda Dórea Anna Carolina Saúde Dantas Lorena Lôbo Brito Morbeck Iasmin Souza Lima Amanda Alves de Almeida Maiara Raulina de Jesus Dias Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，10： | 5 |
| 3 | Laparoscopic adrenalectomy: new gold standard显示文摘 | Smith C D Weber C J Amerson JR | 1999 | World J Surg1999，23，： | 2 |
| 4 | 24h动态中心动脉收缩压和左心室质量的关系:一项前瞻性多中心研究显示文摘研究者在7个欧洲中心中调查左心室质量与肱动脉诊室血压以及肱动脉压和中心动脉动态收缩压之间的关系。使用校准的示波装置测量,经平均压/舒张压校准和转换函数计算中心动脉收缩压。由不知道血压值的单个操作者通过M型超声心动图测定左心室质量。研究者调查了未使用抗高血压药物的受试者289人(女性137人,平均年龄50.8岁)。 | 黄洁 叶鹏 Weber T Wassertheurer S Schmidt-Trucks?ss A Rodilla E Ablasser C Jankowski P Lorenza Muiesan M Giannattasio C Mang C Wilkinson I Kellermair J Hametner B Pascual JM Zweiker R Czarnecka D Paini A Salvetti M Maloberti A McEniery C | 2017 | 中华高血压杂志2017，25，11： | 2 |
| 5 | Effect of salinity,light and temperature on germination in Allenrolfea occidentalis显示文摘 | Gul B Weber D J | 1999 | Canadian Journal of Botany1999，77，： | 1 |
| 6 | The development of an orthotic management protocol for preambulatory children with spastic diplegic cerebral palsy显示文摘 | | 1994 | J Prosthetics Orthotics1994，6，3： | 1 |
| 7 | Ultrasonography in the initial evaluation and follow-up of blunt abdominal injury显示文摘 | Ofner D Weber F | 1993 | Surgery1993，114，3： | 1 |
| 8 | Thalidomide alone Or with dexame, thasone for previously untreated显示文摘 | Weber D Rankink Gavino M | 2003 | Multiple Myeloma J Clin Oncol2003，21，1： | 1 |
| 9 | Rac-PAK signaling stimulates extracellular signal-regulated kinase (ERK) activation by regulating formation of MEK1-ERK eomplexes显示文摘 | Eblen S T Slack J K Weber M J Catling A D | 2002 | Mol Cell Biol2002，22，60： | 1 |
| 10 | Ocean Surface Currents Mapped by Radar显示文摘 | Barrick D E Evans M W Weber B L | 1977 | Science1977，198，： | 1 |
| 11 | Comparison between the reactivity of commercial and synthetic TiO2 photocatalysts显示文摘 | PISCOPO A ROBERT D WEBER J V | 2002 | Journal of Photochem and Photobio A:Chemistry2002，139，： | 1 |
| 12 | Soft tissue reactions to nonsubmerged unloaded titanium implants in beagle dogs显示文摘 | Buser D Weber HP Donath K | 1997 | J Periodontal1997，68，： | 1 |
| 13 | Influence of fly ash on soil physical properties and turfgrass establishment显示文摘 | Adriano D C Weber J T | 2001 | Journal ofEnvironmental Quality2001，30，2： | 1 |
| 14 | Intrahepatic cholangio- carcinoma resectability,recurrence pattern,and outcimes 显示文摘 | Weber SM Jarnagin WR Klirnstra D | 2001 | J Am CoilSurg2001，193，4： | 1 |
| 15 | Limited open reduction and internal fixation of displaced intra-articular fractures of the calcaneum显示文摘 | Weber M Lehmann O Sagesser D | | 0，，12： | 1 |
| 16 | Adaptation of HIV-1to human leukocyte antigen class I显示文摘 | Kawashima Y Pfafferott K Frater J Matthews P Payne R Addo M Gatanaga H Fujiwara M Hachiya A Koizumi H Kuse N Oka S Duda A Prendergast A Crawford H Leslie A Brumme Z Brumme C Allen T Brander C Kaslow R Tang J Hunter E Allen S Mulenga J Branch S Roach T John M Mallal S Ogwu A Shapiro R Prado J G Fidler S Weber J Pybus O G Klenerman P Ndung'u T Phillips R Heckerman D Harrigan P R Walker B D Takiguchi M Goulder P | 2009 | Nature2009，458，7238： | 1 |
| 17 | Bonding properties of metals anodically bonded to glass 显示文摘 | Briand D Weber P Derooij N F | 2004 | Sensors and Actuators A:Physieal2004，114，23： | 1 |
| 18 | Outcome and patterns of failure in testicular lymphoma: a multicenter Rare Cancer Network study显示文摘 | Zouhair A Weber D Belkacémi Y | 2002 | Int J Radiat Oncol Biol Phys2002，52，3： | 1 |
| 19 | Mechanisms of epigenetic and cell -type specific regulation of Hey target genes in ES cells and cardio- myocytes显示文摘 | Weber D Heisig J Kneitz S | 2015 | J Mol Cellular Cardiol2015，79，： | 1 |
| 20 | -Nivolumab versus chemotherapy in patients with advanced melano- ma who progressed after anti-CTLA-4 treatment (CheckMate 037 ) : a randomised, controlled, open- label, phase 3 trial 显示文摘 | Weber JS D'Angelo SP Minor D | 2015 | Lancet Oncol2015，16，4： | 1 |
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