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| 1 | Chronic myeloid leukemia-from the Philadelphia chromosome to specific target drugs:A literature review显示文摘Chronic myeloid leukemia(CML)is a myeloproliferative neoplasm and was the first neoplastic disease associated with a well-defined genotypic anomaly―the presence of the Philadelphia chromosome.The advances in cytogenetic and molecular assays are of great importance to the diagnosis,prognosis,treatment,and monitoring of CML.The discovery of the breakpoint cluster region(BCR)-Abelson murine leukemia(ABL)1 fusion oncogene has revolutionized the treatment of CML patients by allowing the development of targeted drugs that inhibit the tyrosine kinase activity of the BCR-ABL oncoprotein.Tyrosine kinase inhibitors(known as TKIs)are the standard therapy for CML and greatly increase the survival rates,despite adverse effects and the odds of residual disease after discontinuation of treatment.As therapeutic alternatives,the subsequent TKIs lead to faster and deeper molecular remissions;however,with the emergence of resistance to these drugs,immunotherapy appears as an alternative,which may have a cure potential in these patients.Against this background,this article aims at providing an overview on CML clinical management and a summary on the main targeted drugs available in that context. | Mariana Miranda Sampaio Maria Luísa Cordeiro Santos Hanna Santos Marques Vinícius Lima de Souza Gonçalves Glauber Rocha Lima Araújo Luana Weber Lopes Jonathan Santos Apolonio Camilo Santana Silva Luana Kauany de SáSantos Beatriz Rocha Cuzzuol Quézia Estéfani Silva Guimarães Mariana Novaes Santos Breno Bittencourt de Brito Filipe Antônio França da Silva Márcio Vasconcelos Oliveira Cláudio Lima Souza Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，2： | 3 |
| 2 | Benazepril plus amlodipine or hydrochlorothiazide for hypertension in high-risk patients显示文摘 | Jamerson K Weber MA Bakris CL | 2008 | N Engl J Med2008，359，23： | 1 |
| 3 | Climate change policy and international trade: Policy considerations in theUS显示文摘 | Weber CL Peters GP | 2009 | Energy Policy2009，，2： | 1 |
| 4 | Effects of ion channel blockade on the distribution of Na, K, Ca and other elements in soxygen-glucose deprived CA 1 hippocampal neuro- ns显示文摘 | LoPachin RM Gaughan CL Lehning E J Weber ML Taylor CP | 2001 | Neuroscience2001，103，4： | 1 |
| 5 | The Drivers of Chinese CO2Emissions from 1980 to 2030显示文摘 | Guan DB Hubacek K Weber CL | 2008 | Global Environmental Change2008，，18： | 1 |
| 6 | Differential activation of cyclophosphamide and ifosphamide by cytochromes P-450 2B and 3A inhuman liver microsomes显示文摘 | Chang TK Weber GF Crespi CL | 1993 | Cancer Res1993，53，23： | 1 |
| 7 | Study of disorder in pulsed laser deposited double perovskite oxides by first-principle structure prediction显示文摘Double perovskite oxides,with generalized formula A_(2)BB'O_(6),attract wide interest due to their multiferroic and charge transfer properties.They offer a wide range of potential applications such as spintronics and electrically tunable devices.However,great practical limitations are encountered,since a spontaneous order of the B-site cations is notoriously hard to achieve.In this joint experimental-theoretical work,we focused on the characterization of double perovskites La2TiFeO6 and La_(2)VCuO_(6) films grown by pulsed laser deposition and interpretation of the observed B-site disorder and partial charge transfer between the B-site ions.A random structure sampling method was used to show that several phases compete due to their corresponding configurational entropy.In order to capture a representative picture of the most relevant competing microstates in realistic experimental conditions,this search included the potential formation of non-stoichiometric phases as well,which could also be directly related to the observed partial charge transfer.We optimized the information encapsulated in the potential energy landscape,captured via structure sampling,by evaluating both enthalpic and entropic terms.These terms were employed as a metric for the competition of different phases.This approach,applied herein specifically to La_(2)TiFeO_(6),highlights the presence of highly entropic phases above the ground state which can explain the disorder observed frequently in the broader class of double perovskite oxides. | Edoardo Fertitta Sujit Das Debalina Banerjee Farbod Ebrahimi Clément Barraud Kai Du He Tian Chris J.Pickard Cedric Weber Ramamoorthy Ramesh Peter Littlewood David Dubbink | 2021 | npj Computational Materials2021，，1： | 1 |
| 8 | The contribution of Chinese exports to climate change 显示文摘 | WEBER CL PETERS GP GUAN D | 2008 | Energy Policy2008，36，9： | 1 |
| 9 | A unified approach to serial search spread-spectrum code acquisition,Part h General theory 显示文摘 | POLYDOROS A WEBER CL | 1984 | IEEE Trans Communication1984，32，： | 1 |
| 10 | The drivers of Chi- nese CO2 emissions from 1980 to 2030显示文摘 | Guan D Hubacek K Weber CL etal | 2008 | Global Environmental Change2008，，4： | 1 |
| 11 | Spinal cord paralysis following sclerotherapy for esophageal varices显示文摘 | Seidman E Weber AM Mofin CL | 1984 | Hepatology1984，4，5： | 1 |
| 12 | One-hour blood xylose test: a reliable index of small bowel function显示文摘 | Buts JP Morin CL Roy CC Weber A and Bonin A | 1978 | The Journal of Pediatrics1978，90，5： | 1 |
| 13 | Nicotine increases oxidative stress,activates NF-kappaB and GRP78,induces apoptosis and sensitizes cells to genotoxic/xenobiotic stresses by a multiple stress inducer,deoxycholate:relevance to colon carcinogenesis显示文摘 | Crowley Weber CL Dvorakova K Crowley C | 2003 | Chem Biol Interact2003，145，： | 1 |
| 14 | Life Cycle Carbon Footprint of Shale Gas:Review of Evidence and Implications显示文摘 | Weber CL Clavin C | 2012 | Environmental Science & Technology2012，46，11： | 1 |
| 15 | Spinal cord paralysis following sclerotherapy for esophageal varices显示文摘 | Seidman E Weber AM Morin CL | 1984 | Hepatology1984，4，： | 1 |
| 16 | VEGF over - expression induces post - ischaemic neuro - protection, but facilitates haemodynamic stem phenomena 显示文摘 | Wang Y Kilic E Kilic U Weber B Bassetti CL Marti HH Hermann DM | 2005 | Brain2005，，： | 1 |
| 17 | Epidemiological and clinical characteristics of COVID-19 in a Brazilian public hospital显示文摘BACKGROUND The coronavirus disease 2019(COVID-19)pandemic has become a major health concern worldwide.In that context,the understanding of epidemiological and clinical features associated with the disease and its severity is crucial for the establishment of strategies aimed at disease control and remedy.AIM To describe epidemiological features,signs,symptoms,and laboratory findings among severely ill COVID-19 patients from an inten-sive care unit in northeastern Brazil as well as to evaluate predictor factors for disease outcomes.METHODS This is a prospective single-center study that evaluated 115 patients admitted to the intensive care unit in a northeastern Brazilian hospital.RESULTS The patients had a median age of 65.60±15.78 years.Dyspnea was the most frequent symptom,affecting 73.9%of the patients,followed by cough(54.7%).Fever was reported in approximately one-third of patients and myalgia in 20.8%of the patients.At least two comorbidities were found in 41.7%of the patients,and hypertension was the most prevalent(57.3%).In addition,having two or more comorbidities was a predictor of mortality,and lower platelet count was positively associated with death.Nausea and vomiting were two symptoms that were predictors of death,and the presence of a cough was a protective factor.CONCLUSION This is the first report of a negative correlation between cough and death in severely ill severe acute respiratory syndrome coronavirus 2-infected individuals.The associations between comorbidities,advanced age,and low platelet count and the outcomes of the infection were similar to the results of previous studies,highlighting the relevance of these features. | Fillipe Dantas Pinheiro Luana Weber Lopes Rafael Santos Dantas Miranda Dórea Glauber Rocha Lima Araújo Filipe Antônio França da Silva Breno Bittencourt de Brito Maria Luísa Cordeiro Santos Geovani Moreno Santos Júnior Maria Teresa Araújo de Lorenzo Barcia Renata de Amorim Marques AndréBezerra Botelho Anna Carolina Saúde Dantas Davi Tanajura Costa Adriano Fernandes Teixeira Cláudio Lima Souza Lucas Miranda Marques Guilherme Barretos Campos Márcio Vasconcelos Oliveira Dulciene Maria de Magalhães Queiroz Fabrício Freire de Melo | 2023 | World Journal of Clinical Cases2023，11，8： | 0 |
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