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| 1 | 免疫组化联合检测PLK1、p21和p53蛋白预测TP53基因状态:一个独立的乳腺癌预测因子显示文摘有学者认为仅用免疫组化检测p53蛋白难以准确预测TP53基因状态,本实验采用免疫组化联合检测p53和p53调节蛋白预测TP53基因突变状态的准确性。本组38例乳腺癌患者中有19例(50%)检测到TP53基因突变,其中7例TP53截短突变中有5例053免疫组化完全阴性,另外12例TP53点突变中有11例p53免疫组化强阳性。 | Watanabe G Ishida T Furuta A 魏开鹏 邱建龙 | 2015 | 临床与实验病理学杂志2015，31，11： | 7 |
| 2 | Randomized phase II study of gemcitabine and S-1 combination versus gemcitabine alone in the treatment of unresectable advanced pancreatic cancer (Japan Clinical Cancer Research Organization PC-01 study)显示文摘 | Masato Ozaka Yuji Matsumura Hiroshi Ishii Yasushi Omuro Takao Itoi Hisatsugu Mouri Keiji Hanada Yasutoshi Kimura Iruru Maetani Yoshinobu Okabe Masaji Tani Takaaki Ikeda Susumu Hijioka Ryouhei Watanabe Shinya Ohoka Yuki Hirose Masafumi Suyama Naoto Egawa A | 2012 | Cancer Chemotherapy and Pharmacology2012，，5： | 3 |
| 3 | Vitamin K2 selectively induced apoptosis in ovarian TYK-nμ and pancreatic MIA PaCa-2 cells out of eight solid tumor cell lines through a mechanism different from geranylgeraniol显示文摘 | Shibayama Imaau T Sakairi S Watanabe A | | J Cancer Res Clin Oncol0，，： | 2 |
| 4 | Effects of osmotic pressure and adsorption on ultrafiltration of ovalbumin显示文摘 | Nahetani H Nakajima M Watanabe A | 1990 | AIChE J1990，36，： | 2 |
| 5 | Combined deletion of Fxr and Shp in mice induces Cyp17a1 and results in juvenile onset cholestasis显示文摘 | Anakk Sayeepriyadarshini Watanabe Mitsuhiro Ochsner Scott A McKenna Neil J Finegold Milton J Moore David D | 2011 | Journal of Clinical Investigation2011，，1： | 2 |
| 6 | Prognostic value of cyclin E and p53 expression in gastric carcinoma显示文摘 | Sakaguchi T Watanabe A SawadaH Yamada Y Yamashita J Matsuda M Nakajima M Miwa T Hirao T Nakano H | | 0，，： | 2 |
| 7 | Human β-defensin-3 induction in H pylori-infected gastric mucosal tissues显示文摘AIM: To examine human β-defensin-3 (hBD-3) expression in inflamed gastric mucosal tissues or MKN45 gastric cancer cells with or without H pylori infection for better understanding the innate immune response to H pylori. METHODS: We used reverse transcription-polymerase chain reactions and immunohistochemistry to examine hBD-3 expression in inflamed gastric mucosal tissues or MKN45 gastric cancer cells with or without H pylori. Effects of hBD-3 against H pylori were also evaluated. RESULTS: The mean mRNA expression of hBD-3 in H pylori -positive specimens was significantly higher than that in H pylori-negative specimens (P = 0.0002, Mann-Whitney). In addition, unlike uninfected samples, 8 of 15 (53.33%) infected mucosal samples expressed hBD-3 protein. H pylori dose-dependently induced mRNA expression of hBD-3 in MKN45 cells, an effect inhibited by adding anti-toll-like receptor (TLR)-4 antibody. HBD-3 protein completely inhibited H pylori growth. CONCLUSION: Our results suggest that like hBD-2, hBD-3 may be involved in the pathophysiology of H pylori-induced gastritis. | K Kawauchi A Yagihashi N Tsuji N Uehara D Furuya D Kobayashi N Watanabe | 2006 | World Journal of Gastroenterology2006，12，36： | 2 |
| 8 | Transcatheter arterial embolization for the treatment of liver metastases in a patient with malignant pheochromoeytoma显示文摘 | Watanabe D Tanabe A Naruse M el al | 2006 | Endocr J2006，53，： | 1 |
| 9 | The tryptophan hydroxylase 1 (TPH1) gene and risk of schizophrenia: a moderate-scale case-control study and meta-analysis显示文摘 | Watanabe Y Nunokawa A Kaneko N | 2007 | Neurosci Res2007，59，： | 1 |
| 10 | Pivotal role of interleukin-8 in the acute respiratory distress syndrome and cerebral reperfusion injury 显示文摘 | Yokoi K Mukaida N Harada A Yamashita J Watanabe Y Matsushima K | 1997 | J Leukoc Biol1997，62，5： | 1 |
| 11 | Induction of antibodies to a kV region by gene immunization显示文摘 | Raz E Kohsaka H | 1993 | J Immunol1993，151，： | 1 |
| 12 | Conversion of degummed soybean oil to biodiesel fuel with immobilized Candida Antarctica lipase 显示文摘 | Watanabe Y Shimada Y Sugihara A | 2002 | Journal of Molecular Catalysis B: Enzymatic2002，17，： | 1 |
| 13 | Optimization of oligodendrocyte progenitor cell culture method for enhanced survival显示文摘 | Yang Z Watanabe M Nishiyama A | 2005 | J Neurosci Methods2005，149，1： | 1 |
| 14 | Synthesis of palau'amide and its diastereomers:Confirmation of its stereostructure显示文摘 | Sugiyama H Watanabe A Teruya T | 2009 | Tetrahedron Lett2009，50，52： | 1 |
| 15 | Heteroge-neous smooth muscle cell population derived from small andlarger arteries显示文摘 | NAKAMURA A ISOYAMA S WATANABE T | 1998 | Microvasc Res1998，55，1： | 1 |
| 16 | Isolation and identification of alkaline lipase producing microorganisms, cultural conditions and some properties of crude enzymes显示文摘 | Watanabe N Yasuhide O T A Yasuji M | 1997 | Agric Biol Chem1997，41，8： | 1 |
| 17 | Detection of salient curvature features on polygonal surfaces显示文摘 | Watanabe K Belyaev A G | 2001 | Eurographics2001，20，3： | 1 |
| 18 | Effects of Hydrogen Peroxide on Intergranular Stress Corrosion Cracking of Stainless Steel in High Temperature Water, ( Ⅲ ) Crack Growth Rates in Corrosive Environment Determined by Hydrogen Peroxide 显示文摘 | Wada Watanabe A Tachibana M | 2000 | Journal of Nuclear Science and Technology2000，37，10： | 1 |
| 19 | Tacrolimus in corticssteroid-resistant ulcerative colitis 显示文摘 | Matsuhashi N Nakajima A Watanabe K | 2000 | Journal Gastroenterology2000，35，8： | 1 |
| 20 | Partially mismatched pediatric transplants with allogeneic CD34+ blood cells from a related donor显示文摘 | Kawano Y Takaue Y Watanabe A | 1998 | Blood1998，92，9： | 1 |
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