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| 1 | Pioglitazone, a specific ligand of peroxisome proliferator-activated receptor-gamma, protects pancreas against acute cerulein-induced pancreatitis显示文摘ABM: To determine the effect of pioglitazone, a specific peroxisome proliferator-activated receptor-γ(PPARγ) ligand, on the development of acute pancreatitis (AP) and on the expression of heat shock protein 70 (HSP70) in the pancreas. METHODS: AP was induced in rats by subcutaneous infusion of cerulein for 5 h. Pancreatic blood flow was measured by laser Doppler flowmetry. Plasma lipase activity, interleukin-1β (IL-1β) and IL-10 were determined, Pancreatic weight and histology were evaluated and pancreatic DNA synthesis and blood flow as well as pancreatic mRNA for IL-1β and HSP70 were assessed in rats treated with pioglitazone alone or in combination with cerulein. RESULTS: Pioglitazone administered (10-100 mg/kg i.g.) 30 min before cerulein, attenuated dose-dependently the pancreatic tissue damage in cerulein-induced pancreatitis (CIP) as demonstrated by the improvement of pancreatic histology, reduction in plasma lipase activity, plasma concentration of pro-inflammatory IL-1β and its gene expression in the pancreas and attenuation of the pancreatitis-evoked fall in pancreatic blood flow. CIP increased pancreatic HSP70 mRNA and protein expression in the pancreas and this effect was enhanced by pioglitazone treatment. CONCLUSION: Pioglitazone attenuates CIP and the beneficial effect of this pioglitazone is multifactorial probably due to its anti-inflammatory activities, to the suppression of IL-1β and to the over-expression of HSP70. PPARγ ligands could represent a new therapeutic option in the treatment of AP. | Peter C Konturek Artur Dembinski Zygmunt Warzecha Grzegorz Burnat Piotr Ceranowicz Eckhart G Hahn Marcin Dembinski Romana Tomaszewska Stanislaw J Konturek | 2005 | World Journal of Gastroenterology2005，11，40： | 7 |
| 2 | Ischemic preconditioning inhibits development of edematous cerulein-induced pancreatitis: Involvement of cyclooxygenases and heat shock protein 70显示文摘AIM: To determine whether ischemic preconditioning (IP)affects the development of edematous cerulein-induced pancreatitis and to assess the role of cyclooxygenase-1 (COX-1), COX-2, and heat shock protein 70 (HSP 70) in this process.METHODS: In male Wistar rats, IP was performed by damping of celiac artery (twice for 5 min at 5-min intervals).Thirty minutes after IP or sham operation, acute pancreatitis was induced by cerulein. Activity of COX-1 or COX-2 was inhibited by resveratrol or rofecoxib, respectively (10 mg/kg).RESULTS: IP significantly reduced pancreatic damage in cerulein-induced pancreatitis as demonstrated by the improvement of pancreas histology, reduction in serum lipase and poly-C ribonuclease activity, and serum concentration of pro-inflammatory interleukin (IL)-1β.Also, IP attenuated the pancreatitis-evoked fall in pancreatic blood flow and pancreatic DNA synthesis.Serum level of anti-inflammatory IL-10 was not affected by IP. Cerulein-induced pancreatitis and IP increased the content of HSP 70 in the pancreas. Maximal increase in HSP 70 was observed when IP was combined with cerulein-induced pancreatitis. Inhibition of COXs, especially COX-2, reduced the protective effect of IP in edematous pancreatitis.CONCLUSION: Our results indicate that IP reduces pancreatic damage in cerulein-induced pancreatitis and this effect, at least in part, depends on the activity of COXs and pancreatic production of HSP 70. | Zygmunt Warzecha Artur Dembinski Piotr Ceranowicz Stanislaw J Konturek Marcin Dembinski Wieslaw W Pawlik Romana Tomaszewska Jerzy Stachura Beata Kusnierz-Cabala Jerzy W Naskalski Peter C Konturek | 2005 | World Journal of Gastroenterology2005，11，38： | 2 |
| 3 | The puta-tive cancer stem cell marker USP22 is a subunit of the human SAGA complexrequired for activated transcription and cell-cycle progression显示文摘 | Zhang XY Varthi M Sykes SM Phillips C Warzecha C Zhu W | 2008 | Mol Cell2008，299，9： | 1 |
| 4 | Oral immunogenicity of human papillomavirus-like particles expressed in potato显示文摘 | Warzecha H Mason H S Lane C | 2003 | J Virol2003，77，： | 1 |
| 5 | Traumatic chronic instability of the proximal tibiofibular jolnt显示文摘 | JANKE M WARZECHA C BALLMER PM | 2008 | Unfallchirurg2008，111，12： | 1 |
| 6 | Oral immunogenicity of human papillomavirus-like particles expressed in potato显示文摘 | Warzecha H Mason HS Lane C | 2003 | J Virol2003，77，16： | 1 |
| 7 | Oral immunogenicity of human papillomavirus-like expressed in potato显示文摘 | Warzecha H Mason HS Lane C | 2003 | J Virol2003，7，16： | 1 |
| 8 | Plant-based solutions for veterinary immunothera-peutics and prophylactics显示文摘 | Igor Kolotilin Ed Topp Eric Cox Devriendt B Conrad U Joensuu J Stger E Warzecha H McAllister T Potter A McLean M D Hall J C Menassa R | 2014 | Vet Res2014，45，1： | 1 |
| 9 | Oral immunogenicity of human papillomavirus-like particles expressed in potato 显示文摘 | Warzecha H Mason HS Lane C | 2003 | J Virol2003，77，16： | 1 |
| 10 | Oral immunogenicity of hu-man papillomavirus-like particles expressed in potato显示文摘 | WARZECHA H MASON H S LANE C | 2003 | Journal of Virology2003，77，16： | 1 |
| 11 | Oral lmmunogenicity of hu-man papillomavirus-like particles expressed in potato显示文摘 | Warzecha H Mason HS Lane C | 2003 | J Virol2003，77，16： | 1 |
| 12 | Oral immunogenicity of human papillomavirus-like particles expressed in potato 显示文摘 | Warzecha H Mason H S Lane C | 2003 | Journal of Virology2003，77，： | 1 |
| 13 | Oral immunogenicity of human papillomavirus-like particles expressed in potato显示文摘 | Warzecha H Mason HS Lane C | | 0，，16： | 1 |
| 14 | Traumatic chronic in- stability of the proximal tibiofibular joint 显示文摘 | Janke M Warzecha C Ballmer PM | 2008 | Unfallchiru- rg2008，111，12： | 1 |
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