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| 1 | Current concepts on osteonecrosis of the femoral head显示文摘It is estimated that 20000 to 30000 new patients are diagnosed with osteonecrosis annually accounting for approximately 10% of the 250000 total hip arthroplasties done annually in the United States. Thelack of level 1 evidence in the literature makes it difficult to identify optimal treatment protocols to manage patients with pre-collapse avascular necrosis of the femoral head, and early intervention prior to collapse is critical to successful outcomes in joint preserving procedures. There have been a variety of traumatic and atraumatic factors that have been identified as risk factors for osteonecrosis, but the etiology and pathogenesis still remains unclear. Current osteonecrosis diagnosis is dependent upon plain anteroposterior and frog-leg lateral radiographs of the hip, followed by magnetic resonance imaging(MRI). Generally, the first radiographic changes seen by radiograph will be cystic and sclerotic changes in the femoral head. Although the diagnosis may be made by radiograph, plain radiographs are generally insufficient for early diagnosis, therefore MRI is considered the most accurate benchmark. Treatment options include pharmacologic agents such as bisphosphonates and statins, biophysical treatments, as well as joint-preserving and joint-replacing surgeries. the surgical treatment of osteonecrosis of the femoral head can be divided into two major branches: femoral head sparing procedures(FHSP) and femoral head replacement procedures(FHRP). In general, FHSP are indicated at pre-collapse stages with minimal symptoms whereas FHRP are preferred at post-collapse symptomatic stages. It is difficult to know whether any treatment modality changes the natural history of core decompression since the true natural history of core decompression has not been delineated. | Joaquin Moya-Angeler Arianna L Gianakos Jordan C Villa Amelia Ni Joseph M Lane | 2015 | World Journal of Orthopedics2015，6，8： | 94 |
| 2 | Role of retinoids in the prevention and treatment of colorectal cancer显示文摘Vitamin A and its derivatives, retinoids, have been widely studied for their use as cancer chemotherapeutic agents. With respect to colorectal cancer(CRC), several critical mutations dysregulate pathways implicated in progression and metastasis, resulting in aberrant Wnt/β-catenin signaling, gain-of-function mutations in K-ras and phosphatidylinositol-3-kinase/Akt, cyclooxygenase-2 over-expression, reduction of peroxisome proliferatoractivated receptor γ activation, and loss of p53 function. Dysregulation leads to increased cellular proliferation and invasion and decreased cell-cell interaction and differentiation. Retinoids affect these pathways by various mechanisms, many involving retinoic acid receptors(RAR). RAR bind to all-trans-retinoic acid(ATRA) to induce the transcription of genes responsible for cellular differentiation. Although most research concerning the chemotherapeutic efficacy of retinoids focuses on the ability of ATRA to decrease cancer cell proliferation, increase differentiation, or promote apoptosis; as CRC progresses, RAR expression is often lost, rendering treatment of CRCs with ATRA ineffective. Our laboratory focuses on the ability of dietary vitamin A to decrease CRC cell proliferation and invasion via RAR-independent pathways. This review discusses our research and others concerning the ability of retinoids to ameliorate the defective signaling pathways listed above and decrease tumor cell proliferation and invasion through both RAR-dependent and RAR-independent mechanisms. | Catherine C Applegate Michelle A Lane | 2015 | World Journal of Gastrointestinal Oncology2015，7，10： | 2 |
| 3 | Topotecan in the treatment of relapsed small cell lung cancer patients with poor performance status显示文摘 | Treat J Huang C H Lane S R | 2004 | Oncologist2004，9，2： | 1 |
| 4 | Echinoderm faunas of the Hon-gguleleng Formation,Late Devonian(Famennian),Xinjiang-uygur Autonomous Region,People's Republic of China显示文摘 | Lane N G Waters J A Maples C G | 1997 | The Paleonto-logical Society Memoir1997，47，： | 1 |
| 5 | Factorial invariance of LibQUAL + as a measure of library service quality over time 显示文摘 | Lane F C Anderson B Ponce H F | 2012 | Library & Information Science Research2012，34，1： | 1 |
| 6 | Simultaneous,quantitative detection of five whey proteins in multiple samples by surface plasmon resonance显示文摘 | BILLAKANTIJ M FEE C J LANE F R | 2010 | International Dairy Journal2010，20，2： | 1 |
| 7 | Pediatric and adult cochlear implantation 显示文摘 | Witte R J Lane J I Driscoll C L W | 2003 | RadioGraphics2003，23，5： | 1 |
| 8 | Development of Normative Date for the Profile of Mood States for Use with Athletic Samples 显示文摘 | TERRY P C LANE A M | 2000 | JAppl Sport Psycho12000，12，： | 1 |
| 9 | Principles and continuous quality improvement applied to intravenous therapy显示文摘 | Dunavin MK Lane C Parker PE | 1994 | J Intraven Nurs1994，17，5： | 1 |
| 10 | Review of fish swimming modes for aquatic locomotion显示文摘 | SFAKIOTAKIS M LANE D M DAVIES J B C | 1999 | IEEE Journal of Oceanic Engineering1999，24，2： | 1 |
| 11 | A quadrupling of Famen-man pelmatozoan diversity:new late Devonian blastoids and crinoids from northwest China显示文摘 | Waters J A Maples C G Lane N G | 2003 | Journal of Paleontology2003，77，5： | 1 |
| 12 | Association of risperidone treatment response with a polymorphism in the 5--HT2A receptor gene显示文摘 | Lane H Y Chang Y C Chiu C C | 2002 | Am J Psychiatry2002，159，： | 1 |
| 13 | Drugging the p53 pathway: understanding the route to clinical efficacy 显示文摘 | HOE K K VERMA C S LANE D P | 2014 | Nat Rev Drug Discov2014，13，3： | 1 |
| 14 | Image and perceived risk: A study of Uganda and its official tourism website 显示文摘 | Lepp A Gibson H Lane C | 2011 | Tourism Management2011，32，3： | 1 |
| 15 | The growth profile, thermotolerance and biofilm formation of Enterobacter sakazakii grown in infant for- mula milk显示文摘 | Iversen C Lane M Forsythe S | 2004 | Letters in Applied Microbiology2004，38，5： | 1 |
| 16 | Differential niche and Wnt requirements during acute myeloid leukemia progression 显示文摘 | Lane SW Wang YJ Lo Celso C | 2011 | Blood2011，118，10： | 1 |
| 17 | Bisphosphonate treatment in osteoporosis: optimal duration of therapy and the incorporation of a drug holiday 显示文摘 | VILLA J C GIANAKOS A LANE J M | 2016 | HSSJ2016，12，1： | 1 |
| 18 | Partitioning of mono-and polycyclic aromatic hydrocarbons in a river sediment adjacent to a former manufactured gas plant site 显示文摘 | Jafvert C T Lane D Lee L S | 2006 | Chemosphere2006，62，： | 1 |
| 19 | Comparative safety of long-acting inhaled bronchodilators:a cohort study using the UK THIN primary care database显示文摘 | Jara M Lanes SF Wentworth C | 2007 | Drug Saf2007，30，12： | 1 |
| 20 | Some effects of model resolution onsimulated gravity waves generated by deep,mesoscale convec-tion显示文摘 | Lane T P Knievel J C | 2005 | J Atmos Sci2005，62，： | 1 |
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