|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Approaches to establish Q-markers for the quality standards of traditional Chinese medicines显示文摘Traditional Chinese medicine(TCM) has played a pivotal role in maintaining the health of Chinese people and is now gaining increasing acceptance around the global scope. However, TCM is confronting more and more concerns with respect to its quality. The intrinsic 'multicomponent and multitarget' feature of TCM necessitates the establishment of a unique quality and bioactivity evaluation system, which is different from that of the Western medicine. However, TCM is investigated essentially as'herbal medicine' or 'natural product', and the pharmacopoeia quality monographs are actually chemicalmarkers-based, which can ensure the consistency only in the assigned chemical markers, but, to some extent, have deviated from the basic TCM theory. A concept of 'quality marker'(Q-marker), following the 'property-effect-component' theory, is proposed. The establishment of Q-marker integrates multidisciplinary technologies like natural products chemistry, analytical chemistry, bionics, chemometrics,pharmacology, systems biology, and pharmacodynamics, etc. Q-marker-based fingerprint and multicomponent determination conduce to the construction of more scientific quality control system of TCM.This review delineates the background, definition, and properties of Q-marker, and the associated technologies applied for its establishment. Strategies and approaches for establishing Q-marker-based TCM quality control system are presented and highlighted with a few TCM examples. | Wenzhi Yang Yibei Zhang Wanying Wu Luqi Huang Dean Guo Changxiao Liu | 2017 | Acta Pharmaceutica Sinica B2017，7，4： | 51 |
| 2 | Chinese Stroke Association guidelines for clinical management of cerebrovascular disorders: executive summary and 2019 update of clinical management of ischaemic cerebrovascular diseases显示文摘Aim Stroke is the leading cause of disability and death in China.Ischaemic stroke accounts for about 60%-80%of all strokes.It is of considerable significance to carry out multidimensional management of ischaemic cerebrovascular diseases.This evidence-based guideline aims to provide the latest detailed and comprehensive recommendations on the diagnosis,treatment and secondary prevention of ischaemic cerebrovascular diseases.Methods We had performed comprehensive searches of MEDLINE(via PubMed)(before 30 June 2019),and integrated the relevant information into charts and distributed to the writing group.Writing group members discussed and determined the recommendations through teleconference.We used the level of evidence grading algorithm of Chinese Stroke Association to grade each recommendation.The draft was reviewed by the Guideline Writing Committee of Chinese Stroke Association Stroke and finalised.This guideline is fully updated every 3 years.results This evidence-based guideline is based on the treatment,care and prevention of ischaemic cerebrovascular diseases,which emphasises on pathogenesis evaluation,intravenous thrombolysis,endovascular therapy,antiplatelet therapy,prevention and treatment of complications,and risk factor management.Conclusions This updated guideline presents a framework for the management of ischaemic cerebrovascular diseases.Timely first-aid measures,professional care in the acute stage,and proactive secondary prevention will be helpful to patients. | Liping Liu Weiqi Chen Hongyu Zhou Wanying Duan Shujuan Li Xiaochuan Huo Weihai Xu Li'an Huang Huaguang Zheng Jingyi Liu Hui Liu Yufei Wei Jie Xu Yongjun Wang | 2020 | Stroke & Vascular Neurology2020，5，2： | 42 |
| 3 | Pyogenic liver abscess: Changing patterns in approach显示文摘AIM: To define optimum management of the pyogenic liver abscess and assess new trends in treatment. METHODS: One hundred and sixty nine patients with pyogenic liver abscess managed at Sher-i-Kashmir In- stitute of Medical Sciences, Srinagar, Kashmir (India) from July 2001 to August 2006 were studied to evaluate and define the optimum treatment. RESULTS: Mortality in the surgically treated group of patients was 9.4% (12/119), while those treated non-surgically had a fatality rate of 16.66% (7/42). Multiple liver abscesses treated surgically had a surprisingly low mortality of 30%. The biliary tract (64.97%) was the most common cause of liver abscess. Multiple abscesses, mixed organisms and abscess complications are all associated with a significantly increased mortality. However, the lethality of the primary disease process was the most important factor in determining survival.CONCLUSION: Transperitoneal surgical drainage and antibiotics are the mainstay of treatment. Percutaneous drainage is recommended for high risk patients only. | Ajaz A Malik Shams UL Bari Khawaja Abdul Rouf Khurshid Alam Wani | 2010 | World Journal of Gastrointestinal Surgery2010，2，12： | 15 |
| 4 | Endovascular treatment with or without intravenous alteplase for acute ischaemic stroke due to basilar artery occlusion显示文摘Background and purpose It remains controversial if endovascular treatment(EVT)can improve the outcome of patients with acute basilar artery occlusion(BAO).This study aims to compare the functional outcomes between EVT with and without intravenous thrombolysis(IVT)first in patients who had acute ischaemic stroke(AIS)due to BAO.Methods Patients who had AIS with BAO who underwent EVT within 24 hours of onset were enrolled in this multicentre cohort study,and the efficacy and safety were compared between IVT+EVT and direct EVT.The primary outcome was 90-day functional independence.All outcomes were assessed with adjusted OR(aOR)from the multivariable logistic regression.In addition,a meta-analysis was performed on all recently published pivotal studies on functional independence after EVT in patients with BAO.Results Of 310 enrolled patients with BAO,241(78%)were treated with direct EVT and 69(22%)with IVT+EVT.Direct EVT was associated with a worse functional outcome(aOR,0.46(95%CI 0.24 to 0.85),p=0.01).IVT+EVT was associated with a lower percentage of patients who needed≥3 passes of stent retriever(10.14%vs 20.75%).The meta-analysis regression revealed a potential positive correlation between bridging with IVT first and functional independence(r=0.14(95%CI 0.05 to 0.24),p<0.01).Conclusions This study showed that compared with direct EVT,EVT with IVT first was associated with better functional outcomes in patients with BAO treated within 24 hours of onset.The meta-analysis demonstrated similar favourable efficacy of IVT first followed by EVT in patients with BAO. | Ximing Nie David Wang Yuehua Pu Yufei Wei Qixuan Lu Hongyi Yan Xin Liu Lina Zheng Jingyi Liu Xinxuan Yang Yarong Ding Dacheng Liu Wanying Duan Zhe Zhang Zhonghua Yang Miao Wen Weibin Gu Xinyi Hou Xinyi Leng Yuesong Pan Zhongrong Miao Liping Liu | 2022 | Stroke & Vascular Neurology2022，7，3： | 10 |
| 5 | Overexpressed miR-9 promotes tumor metastasis via targeting E-cadherin in serous ovarian cancer显示文摘MicroRNAs (miRNAs ) 玩在在各种各样的癌症的发展和前进的关键角色。不正常的 miR-9 表示仍然保持模糊,并且卵巢的癌症的变形前进上的一致都没被到达。在这研究,从生物信息学分析的结果证明 E-cadherin mRNA 的 3-UTR 被 miR-9 直接调整。酶记者试金结果证实 miR-9 能直接指向这 3-UTR。在卵巢的癌症织物的 miR-9 和 E-cadherin 表示被 qRT-PCR 确定。移植和侵略被在 SKOV3 和 A2780 愈合弯屈和 Transwell 系统试金检测。qRT-PCR 和西方的污点被执行检测上皮 ? 间充质的联系转变的 mRNA 和蛋白质。Immunofluorescence 技术被用来分析表示和 E-cadherin, N-cadherin,和 vimentin 的 subcellular 本地化。结果证明 miR-9 经常与配对的主要的相比是在变形浆液的卵巢的癌症织物的 upregulated。miR-9 的 Upregulation 能 downregulate E-cadherin 的表示但是 upregulate 间充质的标记(N-cadherin 和 vimentin ) 的表示。miR-9 的 Overexpression 能在卵巢的癌症支持房间移植和侵略,并且这些进程能有效地经由 miR-9 禁止者被禁止。因此,我们的学习证明 miR-9 可以经由指向 E-cadherin 和一条新奇潜在的治疗学的途径控制卵巢的癌症的转移支持卵巢的癌症转移。 | Bo Zhou Hongbin Xu Meng Xia Chaoyang Sun Na Li Ensong Guo Lili Guo Wanying Shan Hao Lu Yifan Wu Yuan Li Degui Yang Danhui Weng Li Meng Junbo Hu Ding Ma Gang Chen Kezhen Li | 2017 | Frontiers of Medicine2017，11，2： | 10 |
| 6 | Addition of simvastatin to carvedilol non responders: A new pharmacological therapy for treatment of portal hypertension显示文摘AIM To determine whether addition of simvastatin could be an important pharmacological rescue therapy for carvedilol non-responders. METHODS One hundred and two consecutive patients of cirrhosis of liver with significant portal hypertension were included. Hepatic venous pressure gradient(HVPG) was measured at the base line and after proper optimization of dose; chronic response was assessed at 3 mo. Carvedilol non-responders were given simvastatin 20 mg per day(increased to 40 mg per day at day 15). Carvedilol plus simvastatin was continued for 1 mo and hemodynamic response was again measured at 1 mo.RESULTS A total of 102 patients with mean age of 58.3 ± 6.6 years were included. Mean baseline HVPG was 16.75 ± 2.12 mmH g and after optimization of dose and reassessment of HVPG at 3 mo, mean reduction of HVPG from baseline was 5.5 ± 1.7 mm Hg and 2.8 ± 1.6 mm Hg among responders and non-responders respectively(P < 0.001). Addition of simvastatin to carvedilol non-responders resulted in significant response in 16 patients(42.1%) and thus overall response with carvedilol and carvedilol plus simvastatin was seen in 78 patients(80%). Two patients were removed in chronic protocol study with carvedilol and three patients were removed in carvedilol plus simvastatin study due to side effects.CONCLUSION Addition of simvastatin to carvedilol non-responders may prove to be an excellent rescue therapy in patients with portal hypertension. | Zeeshan Ahmad Wani Sonmoon Mohapatra Afaq Ahmad Khan Ashutosh Mohapatra Ghulam Nabi Yatoo | 2017 | World Journal of Hepatology2017，9，5： | 8 |
| 7 | A study on p53 gene alterations in esophageal squamous cell carcinoma and their correlation to common dietary risk factors among population of the Kashmir valley显示文摘瞄准:为了系统地检验风险因素的关联的程度,例如年龄,与原因的体的 Tp53 分子损害消费了饮食的习惯和家庭倾向在北印度的 Kashmiri 人口之中提高食道的有鳞的房间癌(ESCC ) 的致癌作用严厉。方法:所有情况(n = 51 ) 并且控制(n = 150 ) 是克什米尔山谷的永久居民。基因改变在 Tp53 肿瘤的前 ons 5-8 被决定压制或在 45 个 ESCC 盒子之中的基因组织学地由 PCR-SSCP 分析证实了。为单个癌症盒子的数据(n = 45 ) 并且住院病人控制(n = 150 ) 与非癌症,疾病在癌症的家庭历史上包括了信息,与病人的年龄组一起的三十个占优势的普通饮食的风险因素。在到从这些参数的万物有灵论的数据的 p53 前 ons 的基因损害的关联被 Chi 平方测试与健康控制一起产生到所有 45 个组织学地证实的 ESCC 盒子。结果:(77.8%) 45 中的 35 个组织学地描绘了与 45 正常样品中的 1 个对比的有的类似的体细胞突变从一样的耐心的显示出的细菌线变化从邻近的区域获得了的肿瘤样品。 SSCP 分析表明了改变在 6 上在前被发现的那很普通的 p53 基因(77.7%),那没与个人和 clinicopathological 参数的年龄相关,但是与癌症的家庭历史显示出重要词语索引( P<0.05 )( CD = 58 ),在消费的一个未知地点,和饮食的习惯建议细菌线倾向局部地种芥属蔬菜“ Hakh ”( CD = 19.5 ),红 chillies ( CD = 20.2 ),热咸苏打茶( CD = 2.37 )并且本地烤的面包( CD = 1.1 )。结论:我们的学习建议那体的染色体变化特别在 6 Tp53 基因上的前,在人种上的食道的癌症病人之中,克什米尔山谷的同质的人口是仔细与到各种各样的普通饮食的风险因素,特别热的咸茶,肉,烤的面包和“ Hakh ”的继续的暴露有关,那富于 nitrosoamines 和家庭癌症历史。 | Imtiyaz Murtaza Dhuha Mushtaq Mushtaq A Margoob Amit Dutt Nisar Ahmad Wani Ishfaq Ahmad Mohan Lal Bhat | 2006 | World Journal of Gastroenterology2006，12，25： | 8 |
| 8 | 在良性的胆汁的阻塞的 choledochoduodenostomy 的长期的结果显示文摘 AIM:To determine the long-term results of choledochodudenostomy in patients with benign billiary obstruction.METHODS:This prospective study was conducted at Sheri Kashmir Institute of Medical Sciences Srinagar Kashmir,India over a period of 10 years from January 1997 to December 2007.The total number of patients who underwent choledochoduodenostomy during this period was 270.On the basis of etiology of biliary tract obstruction,patients were divided into a calculus group,an oriental cholangiohepatitis group,a benign biliary stricture group and others.Patients were followed for a variable period of 13 mo to 15 years.RESULTS:Choledochoduodenostomy(CDD) with duodenotomy was performend in four patients.CDD with removal of T-tube,CDD with left hepatic lobectomy and CDD with removal of intra biliary ruptured hydatid was performed in three patients each.In the remaining patients only CDD was performed.Immediate post operative complications were seen in 63(23%) patients,while long-term complications were seen in 28(11%) patients,which were statistically significant.Three patients died during hospitalization while four patients died in the late post-operative period.CONCLUSION:Our conclusion is that CDD is safe and produces good long term results when a permanent biliary drainage procedure is required. | Ajaz A Malik Shiraz A Rather Shams UL Bari Khursheed Alam Wani | 2012 | World Journal of Gastrointestinal Surgery2012，4，2： | 7 |
| 9 | Room temperature ferromagnetism in ultra-thin van der Waals crystals of 1T-CrTe2显示文摘Although many emerging new phenomena have been unraveled in two dimensional(2D)materials with long-range spin orderings,the usually low critical temperature in van der Waals(vdW)magnetic material has thus far hindered the related practical applications.Here,we show that ferromagnetism can hold above 300 K in a metallic phase of 1T-CrTe2 down to the ultra-thin limit.It thus makes CrTe2 so far the only known exfoliated ultra-thin vdW magnets with intrinsic long-range magnetic ordering above room temperature.An in-plane room-temperature negative anisotropic magnetoresistance(AMR)was obtained in ultra-thin CrTe2 devices,with a sign change in the AMR at lower temperature,with−0.6%and+5%at 300 and 10 K,respectively.Our findings provide insights into magnetism in ultra-thin CrTe2,expanding the vdW crystals toolbox for future room-temperature spintronic applications. | Xingdan Sun Wanying Li Xiao Wang Qi Sui Tongyao Zhang Zhi Wang Long Liu Da Li Shun Feng Siyu Zhong Hanwen Wang Vincent Bouchiat Manuel Nunez Regueiro Nicolas Rougemaille Johann Coraux Anike Purbawati Abdellali Hadj-Azzem Zhenhua Wang Baojuan Dong Xing Wu Teng Yang Guoqiang Yu Bingwu Wang Zheng Han Xiufeng Han Zhidong Zhang | 2020 | Nano Research2020，13，12： | 6 |
| 10 | Development of the National Air Quality Health Index-China,2013−2018显示文摘What is already known about this topic?While the establishment of an air quality health index(AQHI)in some countries yielded positive outcomes in communicating health risks of air pollution,China lagged behind in developing its own AQHI.Several research studies of AQHI were conducted in China,but this scientific research has not yet been applied to standards.What is added by this report?This report introduced the method of calculation of Chinese AQHI to be launched in pilot cities.The index in this report was established on the basis of fully drawing on international experience and considering Chinese characteristics.What are the implications for public health practice?The purpose of this report is to guide unified application of the AQHI throughout China and translate scientific evidence into public services to promote public health.Based on the AQHI construction method in this report,an AQHI real-time computing platform and data transfer interface will be developed.The release of AQHI aims to communicate health risk of air pollution and provide scientific health protective guidance to the general public,accordingly to protect people’s health. | Qinghua Sun Huanhuan Zhu Wanying Shi Yu Zhong Yingjian Zhang Tiantian Li | 2021 | China CDC weekly2021，3，4： | 5 |
| 11 | Active Collision Avoidance System Design Based on Model Predictive Control with Varying Sampling Time显示文摘In active collision avoidance,the trajectory tracking controller determines the deviation from the reference path and the vehicle stability.The main objective of this study was to reduce the tracking error and improve the tracking performance in collision avoidance.Unlike the previously proposed model predictive control(MPC)strategies with constant sampling time,an improved MPC controller with varying sampling time based on the hierarchical control framework was proposed in this paper.Compared with the original MPC tracking controller,the improved MPC controller demonstrated better adaptive capability for the varying road adhesion coefficients and vehicle speed on a curved road.The simulation results revealed that the hierarchical control framework generated an optimal trajectory for collision avoidance in real-time by minimizing the potential field energy. | Wanying Xue Ling Zheng | 2020 | Automotive Innovation2020，3，1： | 5 |
| 12 | Correlations Between Single Nucleotide Polymorphisms,Cognitive Dysfunction,and Postmortem Brain Pathology in Alzheimer's Disease Among Han Chinese显示文摘In this study, the distribution of five Alzheimer's disease(AD)-related single nucleotide polymorphisms(SNPs) in the Han population was examined in combination with the evaluation of clinical cognition and brain pathological analysis. The associations among SNPs,clinical daily cognitive states, and postmortem neuropathological changes were analyzed in 110 human brains from the Chinese Academy of Medical Sciences/Peking Union Medical College(CAMS/PUMC) Human Brain Bank.APOE ?4(OR = 4.482, P = 0.004), the RS2305421 GG genotype(adjusted OR = 4.397, P = 0.015), and the RS10498633 GT genotype(adjusted OR = 2.375,P = 0.028) were associated with a higher score on the ABC(Ab plaque score, Braak NFT stage, and CERAD neuritic plaque score) dementia scale. These results advance our understanding of the pathogenesis of AD,the relationship between pathological diagnosis and clinical diagnosis, and the SNPs in the Han population for future research. | Qian Yang Kang Chen Hanlin Zhang Wanying Zhang Changlin Gong Qing Zhang Pan Liu Tianyi Sun Yuanyuan Xu Xiaojing Qian Wenying Qiu Chao Ma | 2019 | Neuroscience Bulletin2019，35，2： | 5 |
| 13 | The diagnostic accuracy of 22-gauge and 25-gauge needles in endoscopic ultrasound-guided fine needle aspiration of solid pancreatic lesions: a meta-analysis显示文摘 | M. Madhoun S. Wani A. Rastogi D. Early S. Gaddam W. Tierney J. Maple | 2013 | Endoscopy2013，，02： | 4 |
| 14 | Enrichment of thermophilic and mesophilic microbial consortia for efficient degradation of corn stalk显示文摘Six different environmental samples were applied to enrich microbial consortia for efficient degradation of corn stalk,under the thermophilic and mesophilic conditions.The consortium obtained from anaerobic digested sludge under thermophilic condition(TC-Y)had the highest lignocellulose-degrading activity.The CO_2yield was 246.73 m L/g VS in23 days,meanwhile,the maximum CO_2production rate was 15.48 mL/(CO_2·d),which was28.75%and 52.27%higher than that under mesophilic condition,respectively.The peak value of cellulase activity reached 0.105 U/mL,which was at least 34.61%higher than the other groups.In addition,49.5%of corn stalk was degraded in 20 days,moreover,the degradation ratio of cellulose,hemicellulose and lignin can reach 52.76%,62.45%and42.23%,respectively.Microbial consortium structure analysis indicated that the TC-Y contained the phylum of Gemmatimonadetes,Acidobacteria,Chloroflexi,Planctomycetes,Firmicutes,and Proteobacteria.Furthermore,the Pseudoxanthomonas belonging to GammaProteobacteria might be the key bacterial group for the lignocellulose degradation.These results indicated the capability of degrading un-pretreated corn stalk and the potential for further investigation and application of TC-Y. | Jun Lu Zhiman Yang Wanying Xu Xiaoshuang Shi Rongbo Guo | 2019 | Journal of Environmental Sciences2019，31，4： | 4 |
| 15 | Novel C-17 spirost protostane-type triterpenoids from Alisma plantago-aquatica with antiinflammatory activity in Caco-2 cells显示文摘Twenty-one protostane-type triterpenoids with diverse structures, including nine new compounds(1 e9), were isolated from the of Alisma plantago-aquatica Linn. Structurally, alisolides A-F(1 e6), composed of an oxole group coupled to a five-membered ring, represent unusual C-17 spirost protostane-type triterpenoids. Alisolide H(8) is a novel triterpenoid with an unreported endoperoxide bridge. Alisolide I(9) represents the first example of 23,24-acetal triterpenoid. Their structures were elucidated based on spectroscopic analysis, wherein the absolute configurations of 4-6, 8 were further confirmed by the Mo2(OAc)4-induced ECD method. Furthermore, all isolates were evaluated for their inhibitory effects on LPS-induced NO production in Caco-2 cells, and all the compounds showed remarkable inhibitory activities, with IC50 values in the range of 0.76 e38.20 mmol/L. | Qinghao Jin Jianqing Zhang Jinjun Hou Min Lei Chen Liu Xia Wang Yong Huang Shuai Yao Bang Yeon Hwang Wanying Wu Dean Guo | 2019 | Acta Pharmaceutica Sinica B2019，9，4： | 3 |
| 16 | Polymer coated nanodiamonds as gemcitabine prodrug with enzymatic sensitivity for pancreatic cancer treatment显示文摘The fabrication of Gemcitabine(GEM) prodrug was reported to be an effective method to enhance its pancreatic cancer treatment efficiency. Here, a kind of nanocarbon-based materials, nanodiamond(ND), was selected as the nanocarrier of GEM, owing to its outstanding surface properties and non-cytotoxicity. The polyelectrolytes,polyethyleneimine and polyacrylic acid, were used to self-assemble outside ND surface through electrostatic forces, followed by attachment of polyethylene glycol to address better biocompatibility. GEM was conjugated with an enzyme-sensitive peptide gly-phe-leu-gly to build up the controlled release platform. From characterization results of dynamic laser scattering, zeta potential and transmission electron microscope, the significant improvement of ND stability in physiological condition was proved. Non-cytotoxicity of this functionalized ND carriers and cytotoxicity of the prodrug against Bx PC-3 pancreatic cancer cells were indicated by methylthiazolyl tetrazolium(MTT) assay. In vivo experiments also revealed its superior anticancer effect compared with free GEM treatment. Therefore, the combination of polymer coated NDs with high surface capability and enzymeresponsive intracellular GEM release make it possible to realize higher treatment efficiency on pancreatic tumor therapy. | Wanying Ye Haijie Han Huan Li Qiao Jin Yuzhou Wu Sabyasachi Chakrabortty Tanja Weil Jian Ji | 2020 | Progress in Natural Science:Materials International2020，30，5： | 3 |
| 17 | 破坏泛素依赖的蛋白水解通路对p53转录激活的抑制作用显示文摘目的 :研究功能性泛素化及蛋白酶体水解过程对p5 3转录激活的影响。方法 :通过瞬时转染报告基因法 ,测定内源、外源性p5 3或p5 3转录活性片断的转录能力 (荧光素酶活性 ) ;Western blot法测定细胞内p5 3及其靶蛋白p2 1waf1 的表达水平。结果 :抑制蛋白酶体水解过程 ,细胞内源、外源性p5 3及p5 3转录活性片断的转录能力均降低 ;泛素化途径缺失时 ,p5 3转录能力被显著抑制 ,虽然细胞内p5 3蛋白堆积 ,但其下游靶蛋白p2 1waf1 的表达却无增加。结论 :p5 | 姚继红 朱千政 崔秀云 Wani AA | 2003 | 肿瘤防治杂志2003，10，5： | 3 |
| 18 | Is intra-operative cholangiography necessary during laparoscopic cholecystectomy? A multicentre rural experience from a developing world country显示文摘AIM: To evaluate the feasibility and safety of performing laparoscopic cholecystectomy (LC) in nonteaching rural hospitals of a developing country without intra-operative cholangiography (IOC). To evaluate the possibility of reduction of costs and hospital stay for patients undergoing LC.METHODS: A prospective analysis of patients with symptomatic benign diseases of gall bladder undergoing LC in three non-teaching rural hospitals of Kashmir Valley from Jan 2001 to Jan 2007. The cohort represented a sample of patients requiring LC, aged 13 to 78 (mean 47.2) years. Main outcome parameters included mortality, complications, re-operation, conversion to open procedure without resorting to IOC, reduction in costs borne by the hospital, and the duration of hospital stay.RESULTS: Twelve hundred and sixty-seven patients (976 females/291 males) underwent laparoscopic cholecystectomy. Twenty-three cases were converted to open procedures; 12 patients developed port site infection, nobody died because of the procedure. One patient had common bile duct (CBD) injury, 4 patients had biliary leak, and 4 patients had subcutaneous emphysema. One cholecystohepatic duct was detected and managed intraoperatively, 1 patient had retained CBD stones, while 1 patient had retained cystic duct stones. Incidental gallbladder malignancy was detected in 2 cases. No long-term complications were detected up to now.CONCLUSION: LC can be performed safely even in non-teaching rural hospitals of a developing country provided proper equipment is available and the surgeons and other team members are well trained in the procedure. It is stressed that IOC is not essential to prevent biliary tract injuries and missed CBD stones. The costs to the patient and the hospital can be minimized by using reusable instruments, intracorporeal sutures, and condoms instead of titanium clips and endobags. | Iqbal Saleem Mir Mir Mohsin Omar Kirmani Tafazul Majid Khurshid Wani Mehmood-ul Hassan Javed Naqshbandi Mohammed Maqbool | 2007 | World Journal of Gastroenterology2007，13，33： | 3 |
| 19 | Pattern of rubber bullet injuries in the lower limbs: A report from Kashmir显示文摘 | Shabir Ahmed Dhar Tahir Ahmed Dar Sharief Ahmed Wani Saheel Maajid Jawed Ahmed Bhat Naseer Ahmed Mir Imtiyaz Hussain Dar Shahid Hussain | 2016 | Chinese Journal of Traumatology2016，19，3： | 3 |
| 20 | Telemedicine,the current COVID-19 pandemic and the future:a narrative review and perspectives moving forward in the USA显示文摘A narrative review was conducted to examine the current state of the utilisation of telemedicine amid the current COVID-19 pandemic and to evaluate the benefits of continuing telemedicine usage in the future.A literature review was performed for articles related to telemedicine.Databases including PubMed,Google Scholar,Cochrane Library and Ovid MEDLINE were searched.Three reviewers independently performed article selection based on relevance to our topic.We included all articles between 1990 and 2020 related to telemedicine using the following keywords:‘telemedicine’,‘telehealth’,‘policy’,‘COVID-19’,‘regulation’,‘rural’,‘physical examination’,‘future’.A total of 60 articles were identified,and through careful selection we narrowed the final number of articles to 42 based on relevance to our topic.Telemedicine has been rapidly evolving over the past several decades.Issues with regulation and reimbursement have prevented its full immersion into the healthcare system.During the current pandemic,Centers for Medicare and Medicaid services have expanded access to telemedicine services.The advantages of telemedicine moving forward include its cost-effectiveness,ability to extend access to specialty services and its potential to help mitigate the looming physician shortage.Disadvantages include lack of available technological resources in certain parts of the country,issues with security of patient data,and challenges in performing the traditional patient examination.It is critically important that changes are made to fully immerse telemedicine services into the healthcare landscape in order to be prepared for future pandemics as well as to reap the benefits of this service in the future. | Asim Kichloo Michael Albosta Kirk Dettloff Farah Wani Zain El-Amir Jagmeet Singh Michael Aljadah Raja Chandra Chakinala Ashok Kumar Kanugula Shantanu Solanki Savneek Chugh | 2020 | Family Medicine and Community Health2020，8，3： | 3 |
您所在的机构暂未开通此部分的功能，请联系管理员