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| 1 | Chronic antiepileptic drug use and functional network efficiency: A functional magnetic resonance imaging study显示文摘AIM To increase our insight in the neuronal mechanisms underlying cognitive side-effects of antiepileptic drug(AED) treatment.METHODS The relation between functional magnetic resonance-acquired brain network measures, AED use, and cognitive function was investigated. Three groups of patients with epilepsy with a different risk profile for developing cognitive side effects were included: A 'low risk' category(lamotrigine or levetiracetam, n=16), an 'intermediate risk' category(carbamazepine, oxcarbazepine, phenytoin, or valproate, n=34) and a 'high risk' category(topiramate, n=5). Brain connectivity was assessed using resting state functional magnetic resonance imaging and graph theoretical network analysis. The Computerized Visual Searching Task was used to measure central information processing speed, a common cognitive side effect of AED treatment. RESULTS Central information processing speed was lower in patients taking AEDs from the intermediate and high risk categories, compared with patients from the low risk category. The effect of risk category on global efficiency was significant(P < 0.05, ANCOVA), with a significantly higher global efficiency for patient from the low category compared with the high risk category(P < 0.05, post-hoc test). Risk category had no significant effect on the clustering coefficient(ANCOVA, P > 0.2). Also no significant associations between information processing speed and global efficiency or the clustering coefficient(linear regression analysis, P > 0.15) were observed. CONCLUSION Only the four patients taking topiramate show aberrant network measures, suggesting that alterations in functional brain network organization may be only subtle and measureable in patients with more severe cognitive side effects. | Tamar M van Veenendaal Dominique M IJff Albert P Aldenkamp Richard H C Lazeron Paul A M Hofman Anton J A de Louw Walter H Backes Jacobus F A Jansen | 2017 | World Journal of Radiology2017，9，6： | 2 |
| 2 | Microembolic signals and intraoperative stroke in carotid endarterectomy显示文摘 | Muller M Behnke S Walter P | 1998 | Acta Neurol Scand1998，97，2： | 2 |
| 3 | Relation-ship of leaf dark respiration to leaf-nitrogen specific leaf area andleaf life span:a test across biomes and functional groups显示文摘 | REICH P B WALTERS M B ELLSWORTH D S | 1998 | Oecologia1998，114，： | 1 |
| 4 | Seismic behavior of composite RCS frame systems显示文摘 | Miehael N Bugeja Joseph M Bracci Walter P MooreJr | 2000 | Joumal of Structural Engineering2000，126，4： | 1 |
| 5 | Secretion of brain natriuretic peptide in patients with aneurysmal subarachnoid haemorrhage显示文摘 | Berendes E Walter M Cullen P | 1997 | Lancet1997，349，9047： | 1 |
| 6 | Kinetics of oil saponification by lead salts in ancient preparations of pharmaceutical lead plasters and painting lead mediums 显示文摘 | Cotte M Checroun E Susini J Dumasc P Tchoreloffd P Besnardd M Walter Ph | 2006 | Talanta2006，70，5： | 1 |
| 7 | MieroRNA expression profiling in prostate cancer显示文摘 | Porkka K P Pfeiffer M J Waltering K K Vessella R L Tammela T L Visakorpi T | 2007 | Cancer Res2007，67，： | 1 |
| 8 | Chronic performance of steroid-eluting epicardial leads in a growing pediatric population:a 10-yearcomparison显示文摘 | HORENSTEIN M S WALTERS H 3rd KARPAWICH P P | 2003 | Pace2003，26，71： | 1 |
| 9 | Return to work 5 years after liver transplantation显示文摘 | D Moyzes M Walter M Rose P Neuhaus B.F Klapp | 2001 | Transplantation Proceedings2001，，5： | 1 |
| 10 | Low-light carbon balance andshade tolerance in the seedlings of woody plants:do winterdeciduous and broad-leaved evergreen species differ?显示文摘 | Walters M B Reich P B | 1999 | New Phytologist1999，143，： | 1 |
| 11 | Sorption phenomenonin subsurgace systems:concepts,models and effects on contaminant fateand transport显示文摘 | WALTER J WEBER J R MCGINLEY P M | 1991 | Water Research1991，25，5： | 1 |
| 12 | Soil-waterbalance approach to quantify groundwater recharge from irrigated cropland in the North China Plain 显示文摘 | Kendy E Gerard-Marchant P Walter M T | 2003 | Hydrological Processes2003，17，10： | 1 |
| 13 | Characterization of natural and artificial low-angle boundaries in YBCO TSMG samples 显示文摘 | Delamare M P Walter H Bringmann B | 2000 | hysica C2000，329，： | 1 |
| 14 | Rice and resistant starch:different content depending on chosen methodogy显示文摘 | SILVA L P da WALTER M DENARDIN C C | 2005 | Journal of Food Composition Analysis2005，18，： | 1 |
| 15 | Somatic mutation of vascular endothelial growth factor receptors in juvenile he- mangioma显示文摘 | Walter J W North P E Waner M | 2002 | Genes Chromosomes Cancer2002，33，3： | 1 |
| 16 | Special injection moulding processes in practical application显示文摘 | Oliver P Andreas F | 2000 | Kunststoffe Plast Europe2000，90，10： | 1 |
| 17 | Hydrogen sensors and switches from electrodeposited palladium mesowire arrays显示文摘 | Favier F Walter E C Zach M P | 2001 | Science2001，293，5338： | 1 |
| 18 | Seismic behavior of composite RCS frames systems显示文摘 | Michael N B Joseph M B Walter P M J | | 0，，04： | 1 |
| 19 | Electrical conductivity, ionic conductivity, optical absorption, and gas separation properties of ionically conductive polymer membranes embedded with Si micro- wire arrays 显示文摘 | Spurgeon J M Walter M G Zhou J Kohl P A Lewis N S | 2011 | Energy ~ Environmental Science2011，4，： | 1 |
| 20 | Generality of leaf trait relationships: a test across six biomes 显示文摘 | Reich P B Ellsworth D S Walters M B | 1999 | Ecology1999，80，6： | 1 |
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