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| 1 | Evaluation of the updated definition of early allograft dysfunction in donation after brain death and donation after cardiac death liver allografts显示文摘BACKGROUND:An updated definition of early allograft dysfunction(EAD) was recently validated in a multicenter study of 300 deceased donor liver transplant recipients.This analysis did not differentiate between donation after brain death(DBD) and donation after cardiac death(DCD) allograft recipients.METHODS:We reviewed our prospectively entered database for all DBD(n=377) and DCD(n=38) liver transplantations between January 1,2006 and October 30,2011.The incidence of EAD as well as its ability to predict graft failure and survival was compared between DBD and DCD groups.RESULTS:EAD was a valid predictor of both graft and patient survival at six months in DBD allograft recipients,but in DCD allograft recipients there was no significant difference in the rate of graft failure in those with EAD(11.5%) compared with those without EAD(16.7%)(P=0.664) or in the rate of death in recipients with EAD(3.8%) compared with those without EAD(8.3%)(P=0.565).The graft failure rate in the first 6 months in those with international normalized ratio ≥1.6 on day 7 who received a DCD allograft was 37.5% compared with 6.7% for those with international normalized ratio <1.6 on day 7(P=0.022).CONCLUSIONS:The recently validated definition of EAD is a valid predictor of patient and graft survival in recipients of DBD allografts.On initial assessment,it does not appear to be a useful predictor of patient and graft survival in recipients of DCD allografts,however a study with a larger sample size of DCD allografts is needed to confirm these findings.The high ALT/AST levels in most recipients of DCD livers as well as the predisposition to biliary complications and early cholestasis make these parameters as poor predictors of graft failure.An alternative definition of EAD that gives greater weight to the INR on day 7 may be more relevant in this population. | Kris P Croome William Wall Douglas Quan Sai Vangala Vivian McAlister Paul Marotta Roberto Hernandez-Alejandro | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，4： | 15 |
| 2 | A comparison of survival and pathologic features of non-alcoholic steatohepatitis and hepatitis C virus patients with hepatocellular carcinoma显示文摘AIM:To compare the clinical outcome and pathologic features of non-alcoholic steatohepatitis(NASH) patients with hepatocellular carcinoma(HCC) and hepatitic C virus(HCV) patients with HCC(another group in which HCC is commonly seen) undergoing liver transplantation.METHODS:Patients transplanted for HCV and NASH at our institution from January 2000 to April 2011 were analyzed.All explanted liver histology and pre-transplant liver biopsies were examined by two specialist liver histopathologists.Patient demographics,disease free survival,explant liver characteristics and HCC features(tumour number,cumulative tumour size,vascular invasion and differentiation) were compared between HCV and NASH liver transplant recipients.RESULTS:A total of 102 patients with NASH and 283 patients with HCV were transplanted.The incidence of HCC in NASH transplant recipients was 16.7%(17/102).The incidence of HCC in HCV transplant recipients was 22.6%(64/283).Patients with NASH-HCC were statistically older than HCV-HCC patients(P < 0.001).A significantly higher proportion of HCV-HCC patients had vascular invasion(23.4% vs 6.4%,P = 0.002) and poorly differentiated HCC(4.7% vs 0%,P < 0.001) compared to the NASH-HCC group.A trend of poorer recurrence free survival at 5 years was seen in HCV-HCC patients compared to NASH-HCC who underwent a Liver transplantation(P = 0.11).CONCLUSION:Patients transplanted for NASH-HCC appear to have less aggressive tumour features compared to those with HCV-HCC,which likely in part accounts for their improved recurrence free survival. | Roberto Hernandez-Alejandro Kris P Croome Martin Drage Nathalie Sela Jeremy Parfitt Natasha Chandok Paul Marotta Cheryl Dale William Wall Douglas Quan | 2012 | World Journal of Gastroenterology2012，18，31： | 5 |
| 3 | Histology of dislocations in endothelial keratoplasty ( DSEK and DLEK) : a laboratory-based,surgical solution to dislocation in 100 conseentive DSEK cases显示文摘 | Terry MA Hoar KL Wall J Ousley P | 2006 | Cornea2006，25，8： | 1 |
| 4 | EGFR expression predicts BRCA1 status in patients with breast eancer显示文摘 | van Diest PJ van der Groep P van der Wall E | 2006 | Clin Cancer Res2006，12，2： | 1 |
| 5 | Reduced quantum fluctuations in resonance fluorescence显示文摘 | Walls D F Zoller P | 1981 | Phys Rev Lett1981，47，10： | 1 |
| 6 | Fragmentation Behavior of Pyrite and Calcite During High-Temperature Processing and Mathematical Simulation 显示文摘 | Yan L Gupta R P Wall T F | 2001 | Energy and Fuels2001，15，2： | 1 |
| 7 | Immediate versus delayed fluid resuscitation for hypotensive patients with penetrating torso injuries 显示文摘 | Biekell W H Wall M J Jr Pepe P E | 1994 | N Engl J Med1994，331，17： | 1 |
| 8 | Soil water status indicator for improved irrigation management 显示文摘 | King B A Wall R W Taberna J P | 2001 | Computers and Electronics in Agriculture2001，32，： | 1 |
| 9 | Spatially distri- buted control network for flow proportional chemical in- jection with center pivot sprinkler irrigation显示文摘 | King B A Wall R W Taberna J P Jr | 2009 | Applied Engineering in Agriculture2009，25，5： | 1 |
| 10 | Comparison of next generation sequencing technologies for transcriptome characterization 显示文摘 | WALL P K LEEBENS-MACK J CHANDERBALI A S | 2009 | BMC Genomics2009，10，1： | 1 |
| 11 | Impact of Performance Obstacles on Intensive Care Nurses' Workload, Perceived Quality and Safety of Care, and Quality of Working Life显示文摘 | Gurses A P Carayon P Wall M | 2009 | Health Serv Res2009，44，21： | 1 |
| 12 | Bosonic-degeneracy-induced quantum correlation in a nonlinear atomic be am splitter显示文摘 | Zhang W P Walls D F | 1995 | Phys Rev1995，52，： | 1 |
| 13 | Risk factors for outbreaks of infectious intestinal disease linked to domestic catering显示文摘 | RYAN M J WALL P G GILBERT R J | 1996 | Commun Dis Rep CDR Rev1996，6，13： | 1 |
| 14 | Interactive analysis of the spatial distribution of disasters using GIS显示文摘 | Wall P A and Devine O J | 2000 | J Geographical system2000，2，： | 1 |
| 15 | Storage of sediment-associated nutrients and contaminants in river channel and floodplain systems显示文摘 | Walling D E Owens P N Carter J Leeks G J L Lewis S Meharg A A and Wright J | 2003 | Applied Geochemistry2003，18，： | 1 |
| 16 | A Fast Sequential Method for Polygonal Approximation of Digitized Curves显示文摘 | K Wall P E Danielsson | 1984 | Computers Vision Graphics Ima-ge Process1984，28，： | 1 |
| 17 | Composite electrolytes from self-assembled colloidal networks显示文摘 | Walls H J Riley M W Fedkiw P S | 2003 | Electrochimica Acta2003，48，： | 1 |
| 18 | Oxy-fuel combustion technology for coal-fired power generation显示文摘 | BUHRE B J P ELLIOTT L K SHENG C D GUPTA R P WALL T F | 2005 | Prog Energy Combust2005，31，4： | 1 |
| 19 | First human transplantation of a bioengineered airway tissue 显示文摘 | Macchiarini P Walles T Biancosino C | 2004 | J Thorac Cardiovasc Surg2004，128，4： | 1 |
| 20 | Cotinine in the serum,sali-va,and urine of nonsmokers,passive smokers,and active smokers显示文摘 | Wall MA Johnson J Jacob P | 1988 | Am J Public Health1988，78，6： | 1 |
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