|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study显示文摘BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with IBS.METHODS In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and Ireland.Depressive,anxiety,and somatization symptoms and sociodemographic characteristics were collected.Four functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive models.We also performed separate analyses for sex and IBS subtypes.SNP scores were calculated as the number of minor alleles of the SNPs above.The impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx assays.RESULTS Depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in IBS.The potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant receptors.CONCLUSION We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with IBS.The SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS. | Sabrina Berens Yuanjun Dong Nikola Fritz Jutta Walstab Mauro D'Amato Tenghao Zheng Verena Wahl Felix Boekstegers Justo Lorenzo Bermejo Cristina Martinez Stefanie Schmitteckert Egbert Clevers Felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller Miriam Goebel-Stengel Hubert Mönnikes Viola Andresen Frieling Thomas Jutta Keller Christian Pehl Christoph Stein-Thöringer Gerard Clarke Timothy G Dinan Eamonn M Quigley Gregory Sayuk Magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler | 2022 | World Journal of Gastroenterology2022，28，21： | 2 |
| 2 | Combinatorial aspects of sharp split separation systems synthesis 显示文摘 | WAHL P E LIEN K M | 1990 | AIChE J1990，36，10： | 2 |
| 3 | The effect of quorum-sensing blockers on the formation of marine microbial communities and larval attachment显示文摘 | Dobretsov S Dahms HU Huang YL Wahl M Qian PY | 2007 | 中国生物学文摘2007，21，6： | 2 |
| 4 | Neurological and behavioral outcomes of focal cerebral ischemia in rats显示文摘 | Wahl F Allix M Plotkine M | 1992 | Stroke1992，23，： | 2 |
| 5 | Brain edema:pathogenesis and therapy 显示文摘 | Schilling L Wahl M | 1997 | Kidney Int Suppl1997，51，59： | 1 |
| 6 | Pharmacology of Curcuma longa显示文摘 | Ammon H Wahl M | 1991 | Planta Med1991，57，1： | 1 |
| 7 | PRC1显示文摘 | Wei Jiang Gretchen Jimenez Nicholas J Wells Thomas J Hope Geoffrey M Wahl Tony Hunter Rikiro Fukunaga | 1998 | Molecular Cell1998，，： | 1 |
| 8 | Tumor necrosis factor increase serum leptin levels in humans显示文摘 | ZUMBACNECH M S BOEHME M W J WAHL P | 1997 | J Clin Endocrinol Metab1997，82，12： | 1 |
| 9 | TGF-beta: a mobile purveyor of immune privilege 显示文摘 | WAHL S M WEN J MOUTSOPOULOS N | 2006 | Immunol Rev2006，213，： | 1 |
| 10 | TG-beta:amobile purveyor of immune privilege显示文摘 | Wahl S M Wen J Moutso P | 2006 | Immunol Rev2006，213，1： | 1 |
| 11 | Resveratrol Attenuates the Release of Inflammatory Cytokines from Human Bronchial Smooth Muscle Ceils Exposed to Lipoteichoic Acid in Chronic Obstructive Pulmonary Disease显示文摘 | Knobloch J Wahl C Feldmann M | 2014 | Basic & Clinical Pharmacology & Toxicology2014，114，2： | 1 |
| 12 | Recent advances in alontm optical ceramic显示文摘 | Joseph M Wahl Thomas M Hartnett Lee M Goldman | 2005 | Proceedings of SPIE2005，5786，： | 1 |
| 13 | Vector-entropy optimizationbased neural-network approach to image reconstruction from projections显示文摘 | Wang Y Wahl F M | 1997 | IEEE Tram on Neural Networks1997，8，5： | 1 |
| 14 | Neurological and behavioral outcomes of focal cerebral ischemia in rats显示文摘 | Wahl F Allix M Plotkine M | 1992 | Stroke1992，23，： | 1 |
| 15 | Metabolic monitoring of breast cancer chemohormontherapy using positron emission tomography initial evaluation显示文摘 | Wahl RL Zasadny K Helvie M | 1993 | J Clin Oncol1993，11，11： | 1 |
| 16 | Cannabinoid receptor-dependent and -independent anti-proliferative effects of omega-3 ethanolamides in androgen receptor-positive and -negative prostate cancer cell lines显示文摘 | BROWN I CASCIO M G WAHLE K W | 2010 | Carcinogenesis2010，31，9： | 1 |
| 17 | Transforming growth factor beta: the good, the bad, and the ugly 显示文摘 | Wahl S M | 1994 | J Exp Med1994，180，： | 1 |
| 18 | Renal tubular epithelial expression of the costimulatory molecule B7RP-1(inducible costimulator ligand)显示文摘 | Schoop R Bilic G Neuweiler J Le Hir M Yoshinaga SK | 2002 | J Am Soc Nephro2002，13，6： | 1 |
| 19 | Dysregulation of LPS-induced Toll-like receptor 4-MyD88 complex formation and IL-1 receptor-associated kinase 1 activation in ndotoxin-tolerant cells显示文摘 | Lentschat A Wahl L M | 2002 | J Immunol2002，169，： | 1 |
| 20 | Anemia in patients with rheumatoid arthritis显示文摘 | Wahle M | 2012 | Z Rheu- matol2012，71，10： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员