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| 1 | 人类与自然耦合系统显示文摘人类与自然系统不断地相互作用促使人类与自然耦合系统(CHANS)的形成与发展。近期的研究揭示了人类与自然耦合系统在组织、空间以及时间上耦合的复杂性。这些耦合在相互作用方面从直接演化到更间接;在联结方面从邻近演化到更远距离;在尺度上,从局部演化到全球;在模式和过程上,从简单演化到复杂。解开如相互影响和突发属性的复杂性,能够导致新的科学发现,并且对于开发生态和社会经济可持续性的有效政策是非常重要的。以解决关于人类与自然耦合系统的基本问题和迎接社会的空前挑战为目的的,真正整合不同学科的机会正显现出来。 | 刘建国 Thomas Dietz Stephen R.Carpenter Carl Folke Marina Alberti Charles L.Redman Stephen H.Schneider Elinor Ostrom Alice N.Pell Jane Lubchenco William W.Taylor 欧阳志云 Peter Deadman Timothy Kratz William Provencher 张淑敏 | 2007 | AMBIO-人类环境杂志2007，36，B12： | 13 |
| 2 | 人γ干扰素/β肿瘤坏死因子重组杂合蛋白对γ干扰素抗性细胞株的杀伤效应显示文摘已有大量研究资料表明,γ干扰素(Interferon γ,IFNγ)、淋巴毒素(Lymphotoxin,LT,又称TNFβ)或肿瘤坏死因子(TNFα),均有杀伤肿瘤细胞的细胞毒效应,并对其作用机理进行了广泛的研究。与此同时还对晚期肿瘤患者进行了临床治疗的探索,也取得了可喜的进展。但有些肿瘤细胞对这两种淋巴因子有天然的或逐渐获得的抗性现象,而且这两者在临床用有效抗癌剂量时,又可出现不同程度的副作用。为此有人用IFN和TNF联合处理肿瘤细胞,发现它们具有协同抗癌效应,这就为低剂量治疗肿瘤以减轻副作用提供了理论依据。据此。 | 丁仁瑞 冯根生 裴洪平 Milton W.Taylor | 1992 | 病毒学报1992，8，4： | 6 |
| 3 | The long‐term management of patients with bleeding duodenal ulcers显示文摘 | M. E.McAlindon J. S. W.Taylor S. D.Ryder | 2003 | Alimentary Pharmacology & Therapeutics2003，，3： | 1 |
| 4 | The Ethics of Respect for Nature显示文摘 | Paul W.Taylor | | 0，，： | 1 |
| 5 | Brain-targeting,acid-responsive antioxidant nanoparticles for stroke treatment and drug delivery显示文摘Stroke is the leading cause of death and disability.Currently,there is no effective pharmacological treatment for this disease,which can be partially attributed to the inability to efficiently deliver therapeutics to the brain.Here we report the development of natural compound-derived nanoparticles(NPs),which function both as a potent therapeutic agent for stroke treatment and as an efficient carrier for drug delivery to the ischemic brain.First,we screened a collection of natural nanomaterials and identified betulinic acid(BA)as one of the most potent antioxidants for stroke treatment.Next,we engineered BA NPs for preferential drug release in acidic ischemic tissue through chemically converting BA to betulinic amine(BAM)and for targeted drug delivery through surface conjugation of AMD3100,a CXCR4 antagonist.The resulting AMD3100-conjugated BAM NPs,or A-BAM NPs,were then assessed as a therapeutic agent for stroke treatment and as a carrier for delivery of NA1,a neuroprotective peptide.We show that intravenous administration of A-BAM NPs effectively improved recovery from stroke and its efficacy was further enhanced when NA1 was encapsulated.Due to their multifunctionality and significant efficacy,we anticipate that A-BAM NPs have the potential to be translated both as a therapeutic agent and as a drug carrier to improve the treatment of stroke. | Shenqi Zhang Bin Peng Zeming Chen Jiang Yu Gang Deng Youmei Bao Chao Ma Fengyi Du Wendy C.Sheu W.Taylor Kimberly J.Marc Simard Daniel Coman Qianxue Chen Fahmeed Hyder Jiangbing Zhou Kevin N.Sheth | 2022 | Bioactive Materials2022，7，10： | 1 |
| 6 | Towards rational treatment of bacterial infections during extended space travel显示文摘 | Peter W.Taylor Andrei P.Sommer | | 0，，： | 1 |
| 7 | Smooth transition exponential smoothing显示文摘 | James W.Taylor | 2004 | J Forecast2004，，6： | 1 |
| 8 | Towards rational treatment of bacterial infections during extended space travel显示文摘 | Peter W.Taylor Andrei P.Sommer | | 0，，： | 1 |
| 9 | Molecular neuropathology of MELAS: level of heteroplasmy in individual neurones and evidence of extensive vascular involvement显示文摘 | J.Betts E.Jaros R. H.Perry A. M.Schaefer R. W.Taylor Z.Abdel‐All R. N.Lightowlers D. M.Turnbull | 2006 | Neuropathology and Applied Neurobiology2006，，： | 1 |
| 10 | Mitochondrial tRNA mutations and disease显示文摘 | John W.Yarham Joanna L.Elson Emma L.Blakely RobertMcFarland Robert W.Taylor | 2010 | WIREs RNA2010，，2： | 1 |
| 11 | Diabetes and oral disease: implications for health professionals显示文摘 | David A.Albert AngelaWard PamelaAllweiss Dana T.Graves William C.Knowler CarolKunzel Rudolph L.Leibel Karen F.Novak Thomas W.Oates Panos N.Papapanou Ann MarieSchmidt George W.Taylor Ira B.Lamster EvanthiaLalla | 2012 | Annals of the New York Academy of Sciences2012，，1： | 1 |
| 12 | Bright spots for inland fish and fisheries to guide future hydropower development显示文摘Hydropower production is one of the greatest threats to fluvial ecosystems and freshwater biodiversity.Now that we have entered the Anthropocene,there is an opportunity to reflect on what might constitute a‘sustainable’Anthropocene in the context of hydropower and riverine fish populations.Considering elements of existing practices that promote favorable social-ecological outcomes(i.e.,‘bright spots’)is timely given that there are plans to expand hydropower capacity in previously undammed rivers,intensify dam development in some of the world's largest river systems,and re-license existing facilities.We approach this from a pragmatic perspective:for the foreseeable future,hydropower will likely remain an important source of renewable electricity.To offer support for moving toward a more‘sustainable’Anthropocene,we provide syntheses of best practices during the siting,design,construction,operation,and compensation phases of hydropower development to minimize impacts on inland fish.For each phase,we offer positive examples(or what might be considered‘bright spots’)pertaining to some of the approaches described within our syntheses,acknowledging that these projects may not be viewed as without ecological and(or)societal detriment by all stakeholders.Our findings underscore the importance of protecting critical habitat and free-flowing river reaches through careful site selection and basinscale planning,infrastructure designs that minimize reservoir effects and facilitate safe passage of fish,construction of hydropower plants using best practices that minimize long-term damage,operating guidelines that mimic natural flow conditions,and compensation that is lasting,effective,inclusive,and locally relevant.Learning from these‘bright spots’may require engagement of diverse stakeholders,professionals,and governments at scales that extend well beyond a given site,river,or even basin.Indeed,environmental planning that integrates hydropower development into broader discussions of conserving regional biodiversity and ecosystem services will be of utmost importance. | William M.Twardek Ian G.Cowx Nicolas W.R.Lapointe Craig Paukert T.Douglas Beard Elena M.Bennett David Browne Andrew K.Carlson Keith D.Clarke Zeb Hogan Kai Lorenzen Abigail J.Lynch Peter B.McIntyre Paulo Pompeu Mark Rogers Alexis Sakas William W.Taylor Taylor D.Ward Zeenatul Basher Steven J.Cooke | 2022 | Water Biology and Security2022，1，1： | 0 |
| 13 | Patterns of sperm use by twice-mated female Queensland fruit flies显示文摘Multiple mating by females,polyandry,is common in insects,including in tephritid fruit flies.Female insects that remate commonly store sperm of multiple males.How the sperm of different males contribute to paternity is an important element of sexual selection.Sexual behavior and reproduction of the Queensland fruit fly(Qfly),Bactrocera tryoni,has been extensively investigated both in relation to understanding this economically important species’reproductive biology and in relation to implications for Sterile Insect Technique(SIT),whereby sterile flies are released to constrain reproduction of pest populations.Despite numerous studies of pre-and postcopulatory sexual selection in Qfly,there have been no direct studies of paternity patterns in polyandrous female Qflies.We used two morphologically distinguishable lines to investigate patterns of sperm use in Qfly.The two lines showed comparable mating performance evidenced by similar mating and remating frequency,copula duration,and proportion of second mate paternity(P2)between reciprocal crosses.The mechanism of sperm usage,with P2 close to 0.5 immediately after the second mating followed by gradual decrease of P2 as females aged,is most consistent with stratification or repositioning of sperm.Patterns observed in the present study are compared with the available information from other tephritid fruit flies,and are discussed in relation to this species’reproductive biology,known patterns of sperm storage,and SIT. | Jason Shadmany Siu F.Lee Thu N.M.Nguyen Phillip W.Taylor | 2022 | Insect Science2022，29，4： | 0 |
| 14 | Evaluating and predicting social behavior of arsenic affected communities:Towards developing arsenic resilient society显示文摘This study uses six machine learning(ML)algorithms to evaluate and predict individuals'social resilience towards arsenicosis-affected people in an arsenic-risk society of rural India.Over 50%of the surveyed communities were found to be resilient towards arsenicosis patients.Logistic regression with inbuilt cross-validation(LRCV)model scored the highest accuracy(76%),followed by Gaussian distributionbased naïve Bayes(GNB)model(74%),C-Support Vector(SVC)(74%),K-neighbors(Kn)(73%),Random Forest(RF)(72%),and Decision Tree(DT)(67%).The LRCV also scored the highest kappa value of 0.52,followed by GNB(0.48),SVC(0.48),Kn(0.46),RF(0.42),and DT(0.31).Caste,education,occupation,housing status,sanitation behaviors,trust in others,non-profit and private organizations,social capital,and awareness played a key role in shaping social resilience towards arsenicosis patients.The authors opine that LRCV and GNB could be promising methods to develop models on similar data generated from a risk society. | Sushant K.Singh Robert W.Taylor Venkatamallu Thadaboina | 2022 | Emerging Contaminants2022，8，1： | 0 |
| 15 | 小型遥感器技术综合卫星MSTI-3指向误差的分析和补偿显示文摘1 引言MSTI-3是一颗于1996年5月16日发射的先进的技术验证卫星,它收集短波红外(SWIR)波段和中波红外(MWIR)波段的数据。MSTI-3任务是勘测地球:收集数据以便对地面特性(如地形和地面水分)和大气特性(如云层和极光)进行分析。1997年4月,分析人员计算了MSTI-3的指向偏差约50英里。本文对工作组具体的故障分析过程做了总结,其中包括查出有效载荷反光镜万向支架滚动编码器和航天器的GPS位置接线板是指向误差源的步骤。 | Howard W.Taylor Lesley M.Rahman Todd C.Probert 陈晓君 | 2002 | 控制工程(北京)2002，，3： | 0 |
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