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您的检索式：作者名="J.Marc Simard"
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| 1 | Brain-targeting,acid-responsive antioxidant nanoparticles for stroke treatment and drug delivery显示文摘Stroke is the leading cause of death and disability.Currently,there is no effective pharmacological treatment for this disease,which can be partially attributed to the inability to efficiently deliver therapeutics to the brain.Here we report the development of natural compound-derived nanoparticles(NPs),which function both as a potent therapeutic agent for stroke treatment and as an efficient carrier for drug delivery to the ischemic brain.First,we screened a collection of natural nanomaterials and identified betulinic acid(BA)as one of the most potent antioxidants for stroke treatment.Next,we engineered BA NPs for preferential drug release in acidic ischemic tissue through chemically converting BA to betulinic amine(BAM)and for targeted drug delivery through surface conjugation of AMD3100,a CXCR4 antagonist.The resulting AMD3100-conjugated BAM NPs,or A-BAM NPs,were then assessed as a therapeutic agent for stroke treatment and as a carrier for delivery of NA1,a neuroprotective peptide.We show that intravenous administration of A-BAM NPs effectively improved recovery from stroke and its efficacy was further enhanced when NA1 was encapsulated.Due to their multifunctionality and significant efficacy,we anticipate that A-BAM NPs have the potential to be translated both as a therapeutic agent and as a drug carrier to improve the treatment of stroke. | Shenqi Zhang Bin Peng Zeming Chen Jiang Yu Gang Deng Youmei Bao Chao Ma Fengyi Du Wendy C.Sheu W.Taylor Kimberly J.Marc Simard Daniel Coman Qianxue Chen Fahmeed Hyder Jiangbing Zhou Kevin N.Sheth | 2022 | Bioactive Materials2022，7，10： | 1 |
| 2 | Pharmacological induced target temperature management after cardiac arrest: the capsaicinoids显示文摘Cardiac or respiratory arrest lasting only a few minutes can inflict grave harm on numerous bodily organs,not least of all,the brain.Neurocognitive deficits,which are often severe and profoundly life altering,remain a major source of morbidity among survivors.Post-arrest brain injury is extraordinarily difficult to treat.With the exception of anti-seizure medications, | J.Marc Simard Xiaofeng Jia Volodymyr Gerzanich | 2017 | Neural Regeneration Research2017，12，10： | 0 |
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