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| 1 | 科学家首次证实深部地幔柱与火山热点的关系显示文摘通过美国劳伦斯伯克利国家实验室国家能源研究科学计算中心(National Energy Research Scientific Computing Center,NERSC)的超级计算机,美国科学家对过去20年间全球发生的273次强震的地震波数据进行了分析,然后对地幔柱进行了成像。借此,科学家们首次观察到地幔柱从地幔底部到上地幔的连续分布,它们在下地幔发生明显地分离,然后一直上升至地表1 000 km以下,最后在上地幔变细,发生偏转和弯曲。因此,当地幔柱上部与热点火山发生联系时,往往并不是垂直的。 | 赵纪东 Scott W.French Barbara Romanowicz | 2015 | 地球科学进展2015，30，9： | 12 |
| 2 | Neonatal gene therapy显示文摘 | Christopher D Porada Nam D Tran Yi Zhao W.French Anderson Esmail D Zanjani | 2000 | Experimental Hematology2000，，6： | 1 |
| 3 | Unfolded p53 in non-neuronal cells supports bacterial etiology of Alzheimer’s disease显示文摘Alzheimer’s disease has proven to be largely intractable to treatment,despite years of research,and numerous trials of therapies that target the hallmarks of the disease-amyloid plaques and neurofibrillary tangles.The etiology of Alzheimer’s disease remains elusive.There is a growing body of evidence for an infectious trigger of Alzheimer’s disease,and,in particular,the focus has been on the oral pathogen Porphyromonas gingivalis(P.gingivalis).Reports of the expression of a misfolded form of p53 in non-neuronal cells(fibroblasts,peripheral blood mononuclear cells,and B cells)and serum,which appears several years before clinical symptoms manifest,may provide further support for the role of bacteria in general,and P.gingivalis in particular,in the initiation of the disease.This review presents a model of the pathway from initial oral infection with P.gingivalis to amyloid plaque formation and neuronal degeneration,via the steps of chronic periodontitis;secretion of the inflammagens lipopolysaccharide and gingipains into the bloodstream;induction of an inflammatory response in both peripheral cells and tissues;disruption of the blood-brain barrier,and entry into the central nervous system of the inflammagens and the P.gingivalis bacteria themselves.In this model,the misfolded p53(or“unfolded p53”;up53)is induced in non-neuronal cells and upregulated in serum as a result of oxidative stress due to lipopolysaccharide from P.gingivalis.up53 is therefore a potential biomarker for early diagnosis of the presence of a causative agent of Alzheimer’s disease.Fastidious dental hygiene and aggressive antibiotic treatment may prevent the patient progressing to clinical Alzheimer’s disease if serum up53 is detected at this pre-symptomatic stage. | Peter W.French | 2022 | Neural Regeneration Research2022，17，12： | 1 |
| 4 | Role of the Proteasome in Ethanol‐Induced Liver Pathology显示文摘 | Terrence M.Donohue Arthur I.Cederbaum Samuel W.French ShirishBarve BinGao Natalia A.Osna | 2007 | Alcoholism: Clinical and Experimental Research2007，，9： | 1 |
| 5 | 中印聚首,暗示世界发生变化显示文摘(新德里)中国总理温家宝周六抵达新德里开始为期四天的访问,访问中将不乏司空见惯的握手及礼宾活动,通常情况下,这不会引起这一地区以外人们的注意。但是这次外交访问将给人完全不同的感觉。也许。 | Howard W.French 张学海 | 2005 | 英语文摘2005，0，6： | 0 |
| 6 | 移民缓解中国老龄化?显示文摘外来移民。美国的移民问题,以及中国应该拥有怎么样的海军规模?
这两个将深刻影响美国、甚至世界的未来的问题,在地球另一边争论不休。前者,川普和科鲁兹等共和党人已经表明了激进的立场,如催促政府在边界修墙,以隔绝非法移民;后者关于中国海军规模, | HOWARD W.FRENCH | 2016 | 21世纪商业评论2016，0，7： | 0 |
| 7 | Preneoplastic foci in mice fed diethyl 1, 4-dihydro, 1,4,6-trimethyl 3,5-pyridine decarboxylate are resistant toprotoporphyrin accumulation显示文摘It has been shown that preneoplastic liver cell foci and hepatic nodules generated by thioacetamide(TAA)in drug-primed mice,which were first fed diethyl 1,4-dihydro,1,4,6-trimethyl 3,5-pyridine decarboxylate(DDC)or griseofulvin(GF)for 5 months were resistant to protoporphyrin accumulation.[1]DDC or GF are potent porphyrinogenic drugs and accumulate protoporphyrin in the mouse liver.Although DDC or GF are withdrawn for 1 month,when treated with TAA,the nodules formed on the 5th or 7th day of treatment were devoid of protoporphyrin deposits.Feeding DDC or GF for 8 months induced liver tumors which were devoid of protoporphyrin deposits.In contrast,the surrounding liver tissue contained numerous protoporphyrin deposits.This could be attributed to the decreased activity of delta-aminolevulinate synthase,the first rate-limiting enzyme in protoporphyrin synthesis. | Samuel W.French MWaheed Roomi | 2015 | Hepatoma Research2015，1，1： | 0 |
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