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| 1 | 男男性接触者的危险性行为:一项通过互联网的调查显示文摘目的 探讨中国大陆使用互联网的男男性接触者 (MSM)的危险性行为。方法 根据知情同意的原则 ,于 2 0 0 1年 8~ 11月在 7个中国同性恋网站招募 35 3名MSM。使用含 85个问题的自填式问卷 ,对他们互联网的使用情况 ,艾滋病知识、态度和危险性行为等进行调查。结果 接近 70 %的被调查者与通过互联网认识的MSM发生过性行为。约三分之二被调查者曾有过未加保护的肛交 ,很少被调查者在口交中使用安全套。结论 危险性行为在中国MSM中较普遍 ,可以通过互联网开展经济有效的艾滋病干预。 | 王全意 GE Lin Michael W Ross | 2004 | 中国艾滋病性病2004，10，5： | 33 |
| 2 | Inhibition of Mcl-1 enhances cell death induced by the Bcl-2-selective inhibitor ABT-199 in acute myeloid leukemia cells显示文摘Acute myeloid leukemia(AML)is a serious disease.The 5-year survival rates remain frustratingly low(65%for children and 26%for adults).Resistance to frontline chemotherapy(usually cytarabine)often develops;therefore a new treatment modality is needed.Bcl-2 family proteins play an important role in balancing cell survival and apoptosis.The antiapoptotic Bcl-2 family proteins have been found to be dysregulated in AML.ABT-199,a BH3 mimetic,was developed to target antiapoptotic protein Bcl-2.Although ABT-199 has demonstrated promising results,resistance occurs.Previous studies in AML show that ABT-199 alone decreases the association of proapoptotic protein Bim with Bcl-2,but this is compensated by increased association of Bim with prosurvival protein Mcl-1,stabilizing Mcl-1,resulting in resistance to ABT-199.In this study,we investigated the antileukemic activity of the Mcl-1-selective inhibitor A-1210477 in combination with ABT-199 in AML cells.We found that A-1210477 synergistically induced apoptosis with ABT-199 in AML cell lines and primary patient samples.The synergistic induction of apoptosis was decreased upon Bak,Bax and Bim knockdown.While A-1210477 treatment alone also increased Mcl-1 protein levels,combination with ABT-199 reduced binding of Bim to Mcl-1.Our results demonstrate that sequestration of Bim by Mcl-1,a mechanism of ABT-199 resistance,can be abrogated by combined treatment with the Mcl-1 inhibitor A-1201477. | Daniel A Luedtke Xiaojia Niu Yihang Pan Jianyun Zhao Shuang Liu Holly Edwards Kang Chen Hai Lin Jeffrey W Taub Yubin Ge | 2017 | Signal Transduction and Targeted Therapy2017，2，1： | 11 |
| 3 | Association of telomere length with authentic pluripotency of ES/iPS cells显示文摘Telomerase 和 telomeres 为干细胞的不定的复制是重要的。最近,体的房间的 telomeres 被发现是 reprogrammed 在导致的 pluripotent 干细胞(iPSCs ) 伸长。然而,在在胚胎的干细胞(转换字符) 或 iPSCs 的 vivo 的发展 pluripotency 的 telomeres 的角色直接没被探讨。我们证明有长 telomeres 的转换字符展出真发展 pluripotency,由完全的转换字符小狗以及 germline 能干的怪物的产生证实了在啮齿类动物可得到的最紧的测试。有短 telomeres 的转换字符显示出减少的 teratoma 形成和怪物生产,并且没能产生完全的转换字符小狗。Telomere 长度高度被相关(r > 0.8 ) 与转换字符的发展 pluripotency。短 telomeres 减少 proliferative 率或转换字符的能力,改变与 telomere epigenetics 有关的基因的表示,为 embryogenesis 重要的下面调整基因并且破坏细菌房间区别。而且,有更长的 telomeres 的 iPSCs 与短 telomeres 比那些与更高的效率产生怪物。我们功能的 telomeres 为 ESCs/iPSCs 的发展 pluripotency 是必要的并且建议那 telomere 长度可以提供一个珍贵标记评估干细胞 pluripotency 的数据表演,特别地当紧测试不是可行的时。 | Junjiu Huang Fang Wang Maja Okuka Na Liu Guangzhen Ji Xiaoying Ye Bingfeng Zuo Minshu Li Ping Liang William W Ge John CM Tsibris David L Keefe Lin Liu | 2011 | Cell Research2011，21，5： | 3 |
| 4 | Effects of mesenchymal stem cells on differentiation, maturation, and function of human monocyte-derived dendritic cells显示文摘 | Zhang,W Ge,W Li,CH You,SG Liao,LM Han,Q Deng,WM Zhao,RCH | 2005 | 中国生物学文摘2005，19，3： | 3 |
| 5 | Engrafted bone marrow-derived flk-(1+) mesenchymal stem cells regenerate skin tissue显示文摘 | Deng W Han Q Liao L Li C Ge W Zhao Z You S Deng H Murad F Zhao RC | 2006 | 中国生物学文摘2006，20，5： | 2 |
| 6 | Blind deblurring of spiral CT images 显示文摘 | Jiang Ming Wang Ge Margaret W | 2003 | IEEE Transactions on Medical Imaging2003，22，7： | 1 |
| 7 | Impulsive effect of continuous-time neural networks under pure structural variations 显示文摘 | GUI Z J GE W G | 2007 | International Journal of Bifurcation and Chaos2007，17，6： | 1 |
| 8 | Positive solutions for second-order m-point boundary value problems显示文摘 | Guo Y P Shan W R Ge W G | 2003 | J Comput ApplMath2003，151，2： | 1 |
| 9 | Reinvestigation of the Sm-Co binary system 显示文摘 | GE W Q WU C H CHUANG Y C | 1993 | Z Metallkd1993，84，： | 1 |
| 10 | Chaos synchronizat-ion and parameter identification of three time scales brushless DC motor system,Chaos显示文摘 | Z M Ge J W Cheng | 2005 | Solitons and Fractals2005，24，： | 1 |
| 11 | Temperature-Dependent Photoluminescence of ZnO Nanorods Prepared by a Simple Solution Route显示文摘 | Lv Y Z Zhang Y H Li C P Ren L R Guo L Xu H B Ding L Yang C L Ge W K and Yang S H | 2007 | Luminescence2007，，： | 1 |
| 12 | Periodic solutions of nonautonomous cellular neural networks with impulses显示文摘 | GUI Z J GE W G | 2007 | Chaos Solitons and Fractals2007，32，： | 1 |
| 13 | Lipid binding regulates synaptic targeting of PICKI, AMPA receptor trafficking, and synaptic plasticity 显示文摘 | Jin W Ge WP Xu J | 2006 | J Neurosci2006，26，： | 1 |
| 14 | Proteomic pro- filing of rice embryos from a hybrid rice cuhivar and its parental lines 显示文摘 | WANG W W MENG B GE X M | 2008 | Proteomics2008，8，22： | 1 |
| 15 | Fabrication of Raspberry SiO2/Polystyrene Particles and Superhydrophobic ParticulateFilm with High Adhesive Force显示文摘 | Xu D Z Wang M Z Ge X W | 2012 | J Mater Chem2012，22，： | 1 |
| 16 | Efficacy and safety of three different cumulative doses of intravenous methylprednisolone for moderate to severe and active graves' orbitopathy 显示文摘 | Bartalena L Krassas GE Wiersinga W | 2012 | J Clin Endocrinol Metab2012，97，12： | 1 |
| 17 | Immunosuppression involving soluble CD83 induces tolerogenic dendritic cells that prevent cardiac al- lograft rejection 显示文摘 | Ge W Arp J Lian D | 2010 | Transplant2010，90，11： | 1 |
| 18 | Update on myocantial bridging 显示文摘 | Mohlenkamp S Hort W Ge J | 2002 | Circulation2002，106，20： | 1 |
| 19 | CIP2A is overexpressed in gastric cancer and its depletion leads to impaired clonogenicity,senescence,or differentiation oftumor cells显示文摘 | Li W Ge Z Liu C | | 0，，12： | 1 |
| 20 | Accruals quality and internal control over financial reporting显示文摘 | Doyle J Ge W McVay S | | 0，，： | 1 |
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