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| 1 | Seropositivity to Helicobacter pylori heat shock protein 60 is strongly associated with intensity of chronic inflammation,particularly in antrum mucosa:an extension of an 18-year follow-up study of cbronic gastritis in Saaremaa,Estonia显示文摘 | Ananieva O Maaroos H | 2001 | FEMS Immunol2001，30，2： | 1 |
| 2 | Vascular endothelial growth factor exression in uterine cervical cancer:correlation with clinicopathologic characteristics and survival显示文摘 | Goncharuk IV Vorobjova LI Lukyanova NY | | 0，，03： | 1 |
| 3 | Association of Helicobacter pylori and gastric autoimmunity:a population-based study显示文摘 | Uibo R Vorobjova T Metsküla K | | 0，，： | 1 |
| 4 | Seropositivity to Helieobaeter pylori heat shock protein 60 is strongly associated with intensity of chronic inflammation, particularly in antrum mucosa: an extension of an 18-year follow-up study of chronic gastritis in Saaremaa, Estonia 显示文摘 | Vorobjova T Ananieva O Maaroos H | 2001 | FEMS Immunol Med Microbiol2001，30，2： | 1 |
| 5 | Helicobacter pylori immunology and vaccines显示文摘 | Vorobjova T Watanabe T Chiba T | 2008 | Helicobacter2008，13，1： | 1 |
| 6 | Vascular endothelial growth factor exression in uterine cervical cancer:correlation with clinicopathologic characteristics and survival显示文摘 | Goncharuk IV Vorobjova LI Lukyanova NY | 2009 | Exp Oncol2009，31，3： | 1 |
| 7 | Immune responses to bile-tolerant helicobacfer species in patients with chronic liver diseases, a randomized population group, and healthy blood donors 显示文摘 | Ananieva O Nilsson I Vorobjova T | 2002 | Clin Diagn Lab Immunol2002，9，： | 1 |
| 8 | Vascular endothelial growth factor exression in uterine cervical cancer:corelation with clinicopathologic characteristics and survival显示文摘 | Goneharuk IV Vorobjova LI Lukyanova NY | 2009 | Exp Oncol2009，31，3： | 1 |
| 9 | Response of IgG1 and IgG2 subclasses to Helicobacter pylori in subjects with chronic inflammation of the gastric mucosa,atrophy and gastric cancer in a country with high Helicobacter pylori infection prevalence显示文摘 | Vorobjova T Ren Z Dunkley M | | 0，，： | 1 |
| 10 | CagA protein sero positivity in a random sample of adult population and gastric cancer in estni-a显示文摘 | Vorobjova T Nilsson I Kull K | 1998 | Ear J Gastroenterol Hepatol1998，10，1： | 1 |
| 11 | An 18-year follow-up study of chronic gastritis and Helicobacter pylori assosiation of CagA positive with development of atrophy and activity of gastritis 显示文摘 | Maaroos HI Vorobjova T Sipponen P | 1999 | Scand J Gastroenterol1999，34，9： | 1 |
| 12 | Vascular endothelial growth factor exression in uterine cervical cancer:correlation with clinicopathologic characteristics and survival显示文摘 | Goncharuk IV Vorobjova LI Lukyanova NY | 2009 | Exp Oncol2009，31，3： | 1 |
| 13 | Celiac disease in patients with type 1 diabetes:a condition with distinct changes in intestinal immunity?显示文摘Two common chronic childhood diseases-celiac disease(CD)and type 1 diabetes(T1D)-result from complex pathological mechanisms where genetic susceptibility,environmental exposure,alterations in intestinal permeability and immune responses play central roles.In this study,we investigated whether these characteristics were universal for CD independently of T1D association.For this purpose,we studied 36 children with normal small-bowel mucosa and 26 children with active CD,including 12 patients with T1D.In samples from the small-bowel mucosa,we detected the lowest expression of tight junction protein 1(TJP1)mRNA in CD patients with T1D,indicating an increase in intestinal permeability.Furthermore,these samples displayed the highest expression of forkhead box P3(FoxP3)mRNA,a marker for regulatory T cells,as compared with other patient groups.At the same time,serum levels of IgA antibodies specific for the CD-related antigens deamidated gliadin and tissue transglutaminase(tTG)were the highest in CD patients with T1D.In contrast,no significant differences were found in IgA or IgG antibodies specific for bovine beta-lactoglobulin or Bifidobacterium adolescentis DSM 20083-derived proteins.There were also no differences in the transamidating activity of serum autoantibodies between patients and control individuals.Our results show that patients with T1D and newly detected CD exhibit severely altered intestinal permeability,strong local immune activation and increased immunoregulatory mechanisms in the small bowel.Further study is required to determine whether these extreme changes in this CD subgroup are due to some specific environmental factors(virus infections),unknown genetic effects or autoimmune reactions to antigenic targets in intracellular tight junctions. | Raivo Uibo Marina Panarina Kaupo Teesalu Ija Talja Epp Sepp Meeme Utt Marika Mikelsaar Kaire Heilman Oivi Uibo Tamara Vorobjova | 2011 | Cellular & Molecular Immunology2011，8，2： | 0 |
| 14 | Increased density of tolerogenic dendritic cells in the small bowel mucosa of celiac patients显示文摘AIM: To investigate the densities of dendritic cells(DCs) and FOXP3+ regulatory T cells(Tregs) and their interrelations in the small bowel mucosa in untreated celiac disease(CD) patients with and without type 1 diabetes(T1D).METHODS: Seventy-four patients(45 female, 29 male, mean age 11.1 ± 6.8 years) who underwent small bowel biopsy were studied. CD without T1 D was diagnosed in 18 patients, and CD with T1 D was diagnosed in 15 patients. Normal small bowel mucosa was found in two T1 D patients. Thirty-nine patients(mean age 12.8 ± 4.9 years) with other diagnoses(functional dyspepsia, duodenal ulcer, erosive gastritis, etc.) formed the control group. All CD patients had partial or subtotal villous atrophy according to the Marsh classification: Marsh grade Ⅲa in 9, grade Ⅲb in 21 and grade Ⅲc in 3 cases. Thirty-nine patients without CD and 2 with T1 D had normal small bowel mucosa(Marsh grade 0). The densities of CD11c+, IDO+, CD103+, Langerin(CD207+) DCs and FOXP3+ Tregs were investigated by immunohistochemistry(on paraffin-embedded specimens) and immunofluorescence(on cryostat sections) methods using a combination of mono- and double-staining. Sixtysixserum samples were tested for Ig A-tissue transglutaminase(t TG) using a fully automated Eli ATM Celikey Ig A assay(Pharmacia Diagnostics, Freiburg, Germany). RESULTS: The density of CD11c+ DCs was significantly increased in CD patients compared with patients with normal mucosa(21.67 ± 2.49 vs 13.58 ± 1.51, P = 0.007). The numbers of FOXP3+ cells were significantly higher in CD patients(10.66 ± 1.50 vs 1.92 ± 0.37, P = 0.0002) and in patients with CD and coexisting T1D(8.11 ± 1.64 vs 1.92 ± 0.37, P = 0.002) compared with patients with normal mucosa. The density of FOXP3+ cells significantly correlated with the histologicalgrade of atrophic changes in the small bowel mucosa according to the March classification(r = 0.62; P < 0.0001) and with levels of Ig A antibody(r = 0.55; P < 0.0001). The densities of IDO+ DCs were significantly higher in CD patients(21.6 ± 2.67 vs 6.26 ± 0.84, P = 0.00003) and in patients with CD and coexisting T1D(19.08 ± 3.61 vs 6.26 ± 0.84, P = 0.004) compared with patients with normal mucosa. A significant correlation was identified between the densities of IDO+ DCs and FOXP3+ T cells(r = 0.76; P = 0.0001). The mean values of CD103+ DCs were significantly higher in CD patients(10.66 ± 1.53 vs 6.34 ± 0.61, P = 0.01) and in patients with CD and associated T1D(11.13 ± 0.72 vs 6.34 ± 0.61, P = 0.00002) compared with subjects with normal small bowel mucosa. The mean value of Langerin+ DCs was higher in CD patients compared with persons with normal mucosa(7.4 ± 0.92 vs 5.64 ± 0.46, P = 0.04).CONCLUSION: The participation of diverse DC subsets in the pathological processes of CD and the possible involvement of tolerogenic DCs in Tregs development to maintain intestinal immunological tolerance in CD patients are revealed. | Tamara Vorobjova Oivi Uibo Kaire Heilman Raivo Uibo | 2015 | World Journal of Gastroenterology2015，21，2： | 0 |
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