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| 1 | A review of potential biomarkers for assessing physical and psychological trauma in paediatric burns显示文摘Biological markers that evaluate physical healing as well as psychological impact of a burn are essential for effective treatment of paediatric burns.The objective of this review is to summarize the evidence supporting the use of biomarkers in children with burns.An extensive review of the literature was performed using PubMed.A total of 59 biomarkers were identified relating to burn presence,specifically relating to processes involved in inflammation,wound healing,growth and metabolism.In addition,biomarkers involved in the stress response cascade following a burn trauma were also identified.Although many biomarkers have been identified that are potentially associated with burn-related physical and psychological trauma,an understanding of burn biology is still lacking in children.We propose that future research in the field of children’s burns should be conducted using broad screening methods for identifying potential biomarkers,examine the biological interactions of different biomarkers,utilize child-appropriate biological fluids such as urine or saliva,and include a range of different severity burns.Through further research,the biological response to burn injury may be fully realized and clinically relevant diagnostic tests and treatment therapies utilizing these biomarkers could be developed,for the improvement of healing outcomes in paediatric burn patients. | Morgan Carlton Joanne Voisey Tony J.Parker Chamindie Punyadeera Leila Cuttle | 2021 | Burns & Trauma2021，9，1： | 2 |
| 2 | Dentin matrix protein 1 and phosphate homeostasis are critical for postnatal pulp, dentin and enamel formation显示文摘Deletion or mutation of dentin matrix protein 1 (DMP1) leads to hypophosphatemic rickets and defects within the dentin. However, it is largely unknown if this pathological change is a direct role of DMP1 or an indirect role of phosphate (Pi) or both. It has also been previously shown that Klotho-deficient mice, which displayed a high Pi level due to a failure of Pi excretion, causes mild defects in the dentinal structure. This study was to address the distinct roles of DMP1 and Pi homeostasis in cell differentiation, apoptosis and mineralization of dentin and enamel. Our working hypothesis was that a stable Pi homeostasis is critical for postnatal tooth formation, and that DMP1 has an antiapoptotic role in both amelogenesis and dentinogenesis. To test this hypothesis, Dmp1-null (Dmp1 2/2 ), Klotho-deficient (kl/kl), Dmp1/Klotho-double-deficient (Dmp1 2/2 /kl/kl) and wild-type (WT) mice were killed at the age of 6 weeks. Combinations of X-ray, microcomputed tomography (mCT), scanning electron microscopy (SEM), histology, apoptosis and immunohistochemical methods were used for characterization of dentin, enamel and pulp structures in these mutant mice. Our results showed that Dmp1 2/2 (a low Pi level) or kl/kl (a high Pi level) mice displayed mild dentin defects such as thin dentin and a reduction of dentin tubules. Neither deficient mouse line exhibited any apparent changes in enamel or pulp structure. However, the double-deficient mice (a high Pi level) displayed severe defects in dentin and enamel structures, including loss of dentinal tubules and enamel prisms, as well as unexpected ectopic ossification within the pulp root canal. TUNEL assay showed a sharp increase in apoptotic cells in ameloblasts and odontoblasts. Based on the above findings, we conclude that DMP1 has a protective role for odontoblasts and ameloblasts in a pro-apoptotic environment (a high Pi level). | Afsaneh Rangiani Zheng-Guo Cao Ying Liu Anika Voisey Rodgers Yong Jiang Chun-Lin Qin Jian-Quan Feng | 2012 | International Journal of Oral Science2012，4，4： | 2 |
| 3 | Melt- ejection during laser drilling of metals 显示文摘 | Voisey K T Kudesia S S Rodden W S O | 2003 | Materials Science and Engineering A2003，356，12： | 1 |
| 4 | Human papilloma virus (HPV) ET-mediated attenuation of retinoblastoma (Rb) induces hPygopus2 expression via Elf-1 in cervical cancer显示文摘 | Tzenov Y R Andrews P G Voisey K | 2013 | Mol Cancer Res2013，11，1： | 1 |
| 5 | Post-natal effect of overexpressed DKK1 on mandibular molar formation 显示文摘 | Han X L Liu M Voisey A | 2011 | J Dent Res2011，90，11： | 1 |
| 6 | Melt ejection during laser drilling of metals显示文摘 | Voisey K T Kudesia S S Rodden W S O | 2003 | Materials Science and Engineeri ng:A2003，356，12： | 1 |
| 7 | Agouti signal protein regulation in human melanoma cells显示文摘 | Voisey J Kelly G Van Daal A | 2003 | Pigment Cell Res2003，16，1： | 1 |
| 8 | EpichloO endophytes grow by intercalary hyphal extension in elongating grass leaves显示文摘 | Christensen M J Bennett R J Ansari H A Koga H Johnson R D Bryan G T Simpson W R Koolaard J P Nickless E M Voisey C R | 2008 | Fungal Genetics and Biology2008，45，2： | 1 |
| 9 | Investigation into the effect of beam shape on melt pool characteristics using analytical modelling显示文摘 | Ahmed N Voisey K T Mccartney D G | 2010 | Optics and Lasers in Engine ering2010，48，5： | 1 |
| 10 | Agouti: from mouse to man, from skin to fat 显示文摘 | Voisey J van Daal A | 2002 | Pigment Celt Res2002，15，： | 1 |
| 11 | Agouti : from mouse to man, from skin to coat显示文摘 | Voisey J van Daal A | 2002 | Pigment Cell Research2002，15，1： | 1 |
| 12 | Melanocortins and their receptors and antagonists显示文摘 | Voisey J Carroll L van Daal A | 2003 | Curr Drug Targets2003，4，7： | 1 |
| 13 | A DRD2 and ANKK1 haplotype is associated with nicotine dependence显示文摘 | Voisey J Swagell CD Hughes IP | 2012 | Psychiatry Res2012，196，： | 1 |
| 14 | SNP technologies for drug discovery:a current review显示文摘 | Voisey J Morris CP | 2008 | Current Drug Discozeery Technologies2008，5，： | 1 |
| 15 | Mechanical properties and microstructure of VPS and HVOF CoNi- CrA1Y coatings 显示文摘 | Saeidi S Voisey K T McCartney D G | 2011 | Journal of Thermal Spray Tech- nology2011，20，6： | 1 |
| 16 | Melanocortins and their receptors and antagonists显示文摘 | Voisey J Carroll L van Daal A | 2003 | Curr Drug Targets2003，4，7： | 1 |
| 17 | Agouti: From mouse to man,from skinto fat显示文摘 | Voisey J Vandaal A | 2002 | Pigment CellResearch2002，1510，18： | 1 |
| 18 | A polymorphism in the dysbindin gene(DTNBPI)associated with multiple psychiatric disorders including schizophrenia显示文摘 | Voisey J Swagell CD Hughes IP | | 0，，： | 1 |
| 19 | Corrosion behaviour of crystalline and amorphous forms of the glass forming alloy Fe 43 Cr 16 Mo 16 C 15 B 10显示文摘 | M.S. Bakare K.T. Voisey K. Chokethawai D.G. McCartney | 2012 | Journal of Alloys and Compounds2012，，： | 1 |
| 20 | Analysis of HapMap tag-SNPs in dysbindin (DTNBP1) reveals evidence of consistent association with schizophrenia显示文摘 | Voisey J Swagell CD Hughes IP | 2010 | Eur Psychiatry2010，25，6： | 1 |
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