|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | MAP3K1 and MAP2K4 mutations are associated with sensitivity to MEK inhibitors in multiple cancer models显示文摘激活 mitogen 的蛋白质 kinase (MAPK ) 的激活小径在癌症是经常的。药发展努力在这条小径集中于 kinases,最尤其是在皇家空军和 MEK 上。我们这里证明 MEK 抑制激活通过 DUSP4 的抑制发信号的 JNK6 月,导致她的受体酷氨酸 Kinases 的激活。这面对药刺激 MAPK 小径,从而弄钝 MEK 抑制的效果。失去了 MAP3K1 或 MAP2K4 的癌症没能因而激活 JNK-JUN. ,在 MAP3K1 或 MAP2K4 的 loss-of-function 变化由在 MEK 抑制之上停用 JNK-JUN-mediated 反馈循环授与敏感到 MEK 抑制。在 168 个耐心的导出的异种皮移植(PDX ) 肿瘤的一块面板, MAP3K1 和 MAP2K4 变化地位是对 MEK 抑制的反应的一个强壮的预言者。我们的调查结果建议在 MAP3K1 或 MAP2K4 有变化的癌症,在胸,前列腺和冒号的肿瘤经常,可以对 MEK 禁止者作出回应。我们的调查结果也建议 MAP3K1 和 MAP2K4 是在有 MEK 禁止者的联合的潜在的药目标,尽管有他们被肿瘤 suppressor 基因编码的事实。 | Zheng Xue Daniel J. Vis Alejandra Bruna Tonci Sustic Sake van Wageningen Ankita Sati Batra Oscar M. Rueda Evert Bosdriesz Carlos Caldas Lodewyk F. A. Wessels Rene Bernardt | 2018 | Cell Research2018，28，7： | 5 |
| 2 | Value of a comprehensive geriatric assessment for predicting one-year outcomes in patients undergoing transcatheter aortic valve implantation: results from the CGA-TAVI multicentre registry显示文摘Background In a three-month report from the CGA-TAVI registry, we found the Multidimensional Prognostic Index (MPI) and Short Physical Performance Battery (SPPB) to be of value for predicting short-term outcomes in elderly patients undergoing transcatheter aortic valve implantation (TAVI). In the present analysis, we examined the association of these tools with outcomes up to one year post-TAVI. Methods CGA-TAVI is an international, observational registry of geriatric patients undergoing TAVI. Patients were assessed using the MPI and SPPB. Efficacy of baseline values and any postoperative change for predicting outcome were established using logistic regression. Kaplan- Meier analysis was carried out for each comprehensive geriatric assessment tool, with survival stratified by risk category. Results One year after TAVI, 14.1% of patients deceased, while 17.4% met the combined endpoint of death and/or non-fatal stroke, and 37.7% the combined endpoint of death and/or hospitalisation and/or non-fatal stroke. A high-risk MPI score was associated with an increased risk of all-cause mortality (aOR = 36.13, 95% CI: 2.77–470.78, P = 0.006) and death and/or non-fatal stroke (aOR = 10.10, 95% CI: 1.48–68.75, P = 0.018). No significant associations were found between a high-risk SPPB score and mortality or two main combined endpoints. In contrast to a worsening SPPB, an aggravating MPI score at three months post-TAVI was associated with an increased risk of death and/or non-fatal stoke at one year (aOR = 95.16, 95% CI: 3.41–2657.01). Conclusions The MPI showed value for predicting the likelihood of death and a combination of death and/or non-fatal stroke by one year after TAVI in elderly patients. | Martijn S.van Mourik Nathalie van der Velde Giulio Mannarino Marie-Pierre Thibodeau Jean-Bernard Masson Gennaro Santoro Jan Baan Sofie Jansen Jana Kurucova Martin Thoenes Cornelia Deutsch ANDreas W.Schoenenberger ANDrea Ungar Peter Bramlage M Marije Vis | 2019 | Journal of Geriatric Cardiology2019，16，6： | 3 |
| 3 | A Survey of Literature on Automated Storage and Retrieval Systems 显示文摘 | Roodbergen K j Vis I F A | 2008 | European Journal of Operational Research2008，，1： | 1 |
| 4 | Prostatic intraepithelial neoplasia and putative precursor lesions of prostate cancer:a clinical perspective显示文摘 | Vis AN Van Der Kwast TH | 2001 | BJU Int2001，88，2： | 1 |
| 5 | Lost - sales inventory systems with service level criterion 显示文摘 | Bijvank M Vis I F | 2012 | European Journal of Operational Research2012，220，3： | 1 |
| 6 | Survey of research in the design and control of au- tomated guided vehicle systems 显示文摘 | VIS I F A | 2006 | European Journal of Op- erational Research2006，170，3： | 1 |
| 7 | Clinical outcomes after percutaneous or surgical revascularization of unprotected left main coronary artery-related acute myocardial infarction:a single-center experience显示文摘 | Grundeken M J Vis M M Beijk M A | 2013 | Heart2013，99，10： | 1 |
| 8 | Inflammatory Rheumatic Disorders and Bone显示文摘 | Irene Bultink Marijn Vis Irene Horst-Bruinsma Willem Lems | 2012 | Current Rheumatology Reports2012，，3： | 1 |
| 9 | Story telling from pictures using the Edmonton Narrative Norms Instrument显示文摘 | Phyllis S Denyse H Rita Vis Dube | 2006 | Journal of Speech Pathology and Audiology2006，30，4： | 1 |
| 10 | Determination of the number of automated guided vehicles required at a semi-automated container terminal显示文摘 | Vis I F A de Koster R Roodbergen K J Peeters L W P | 2001 | Journal of the operation research society2001，52，： | 1 |
| 11 | A systematic review and meta-analysis of intra-aortic balloon pump therapy in ST-elevation myocardial infarction: should we change the guidelines? 显示文摘 | Sjauw KD Engstrom AE Vis MM | 2009 | Eur Heart J2009，30，4： | 1 |
| 12 | Macroalgal communities from an acid mine drainage impacted watershed显示文摘 | Verb RG Vis ML | 2001 | Aquatic Botany2001，71，2： | 1 |
| 13 | How to guide life cycle assessment properly显示文摘 | Krozer J Vis J C | 1998 | Journal of Cleaner production1998，6，1： | 1 |
| 14 | Trace Element Determinations Using a 15 keV Synchrotron X-ray Microprobe 显示文摘 | Langevelde F Vis R D | 1991 | AnalChem1991，63，： | 1 |
| 15 | Re : Transvaginal cervical length measurement for prediction of preterm birth in women with threat- ened preterm labor: a meta-analysis 显示文摘 | Wiegerinck MM Vis JY Mo! BW | 2010 | Ultrasound Obstet Gyne- col2010，35，6： | 1 |
| 16 | Survey of Research in the Design and Control of Automated Guided Vehicle Systems 显示文摘 | Vis I F A | 2006 | European Journal of Operational Research2006，170，3： | 1 |
| 17 | A model for warehouse layout显示文摘 | Roodbergen K J Vis I F A | 2006 | HE Transactions2006，38，10： | 1 |
| 18 | Relation Between the Assessment of Microvascular Injury by Cardiovascular Magnetic Resonance and Coronary Doppler Flow Velocity Measurements in Patients With Acute Anterior Wall Myocardial Infarction显示文摘 | Alexander Hirsch Robin Nijveldt Joost D.E. Haeck Aernout M. Beek Karel T. Koch José P.S. Henriques Rene J. van der Schaaf Marije M. Vis Jan Baan Robbert J. de Winter Jan G.P. Tijssen Albert C. van Rossum Jan J. Piek | 2008 | Journal of the American College of Cardiology2008，，23： | 1 |
| 19 | Phylogeny of the Batrachospermales(Rhodophyta)Inferred from RbeL and 18 S Ribosomal DNA Gene Sequences显示文摘 | VIS M L SAUNDERS G W SHEATH R G | 1998 | Journal of Phycology1998，34，： | 1 |
| 20 | Welfare of farmed fish in present and future production systems显示文摘 | KIESSLING A VAN DE VIS H FLIK G | | 0，，01： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员