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| 1 | Spectroscopic analysis on the binding interaction of biologically active pyrimidine derivative with bovine serum albumin显示文摘A biologically active antibacterial reagent, 2–amino-6-hydroxy–4–(4-N, N-dimethylaminophenyl)-pyrimidine-5-carbonitrile(AHDMAPPC), was synthesized. It was employed to investigate the binding interaction with the bovine serum albumin(BSA) in detail using different spectroscopic methods. It exhibited antibacterial activity against Escherichia coli and Staphylococcus aureus which are common food poisoning bacteria. The experimental results showed that the fluorescence quenching of model carrier protein BSA by AHDMAPPC was due to static quenching. The site binding constants and number of binding sites(n E 1) were determined at three different temperatures based on fluorescence quenching results. The thermodynamic parameters, enthalpy change(ΔH), free energy(ΔG) and entropy change(ΔS) for the reaction were calculated to be 15.15 k J/mol, –36.11 k J/mol and 51.26 J/mol K according to van't Hoff equation, respectively. The results indicated that the reaction was an endothermic and spontaneous process, and hydrophobic interactions played a major role in the binding between drug and BSA. The distance between donor and acceptor is 2.79 nm according to F?rster's theory. The alterations of the BSA secondary structure in the presence of AHDMAPPC were confirmed by UV–visible, synchronous fluorescence, circular dichroism(CD) and three-dimensional fluorescence spectra. All these results indicated that AHDMAPPC can bind to BSA and be effectively transported and eliminated in the body. It can be a useful guideline for further drug design. | Vishwas D. Suryawansht Laxman S. Walekar Anil H. Gore Prashant V. Anbhule Govind B. Kolekar | 2016 | Journal of Pharmaceutical Analysis2016，6，1： | 7 |
| 2 | Smoking under hypoxic conditions: a potent environmental risk factor for inflammatory and autoimmune diseases显示文摘Autoimmune disease management presents a significant challenge to medical science. Environmental factors potentially increase the risk of developing inflammatory and autoimmune diseases, such as multiple sclerosis, rheumatoid arthritis, and lupus. Among various environmental stresses, cigarette smoke and hypoxia have both been reported to lead to an enhanced risk of inflammatory and autoimmune diseases. In this review, we shed light on all reported mechanisms whereby cigarette smoke and a hypoxic environment can induce inflammatory and autoimmune diseases and discuss how hypoxic conditions influence the cigarette smoke-induced threat of inflammatory and autoimmune disease development. Cigarette smoke and hypoxia both lead to increased oxidative stress and production of reactive oxygen species and other free radicals, which have various effects including the generation of autoreactive pro-inflammatory T cells and autoantibodies, reductions in T regulatory(Treg) cell activity, and enhanced expression of pro-inflammatory mediators [e.g., interleukin-6(IL-6), interleukin-4(IL-4) and interleukin-8(IL-8)]. Accordingly, smoking and hypoxic environments may synergistically act as potent environmental risk factors for inflammatory and autoimmune diseases. To our knowledge, no studies have reported the direct association of cigarette smoke and hypoxic environments with the risk of developing inflammatory and autoimmune diseases. Future studies exploring the risk of autoimmune disease development in smokers at high altitudes, particularly military personnel and mountaineers who are not acclimatized to high-altitude regions, are required to obtain a better understanding of disease risk as well as its management. | Md.Saddam Hussain Vishwas Tripathi | 2018 | Military Medical Research2018，5，3： | 3 |
| 3 | Effect of replenishment of vitamin D on survival in patients with decompensated liver cirrhosis:A prospective study显示文摘AIM To assess the vitamin D(VD) deficiency as a prognostic factor and effect of replenishment of VD on mortality in decompensated cirrhosis. METHODS Patients with decompensated liver cirrhosis were screened for serum VD levels. A total of 101 VD deficient patients(< 20 ng/mL) were randomly enrolled in two groups: Treatment group(n = 51) and control group(n = 50). Treatment group received VD treatment in the form of intramuscular cholecalciferol 300000 IU as loading dose and 800 IU/d oral as maintenance dose along with 1000 mg oral calcium supplementation. The VD level, clinical parameters and survival of both the groups were compared for 6-mo.RESULTS Prevalence of vitamin D deficiency(VDD) in decompensated CLD was 84.31%. The mean(SD) age of the patients in the treatment group(M:F: 40:11) and control group(M:F: 37:13) were 46.2(± 14.93) years and 43.28(± 12.53) years, respectively. Baseline mean(CI) VD(ng/mL) in control group and treatment group were 9.15(8.35-9.94) and 9.65(8.63-10.7), respectively. Mean(CI) serum VD level(ng/mL) at 6-mo in control group and treatment group were 9.02(6.88-11.17) and 29(23-35), respectively. Over the period of time the VD, calcium and phosphorus level was improved in treatment group compared to control group. There was nonsignificant trend seen in greater survival(69% vs 64%; P > 0.05) and longer survival(155 d vs 141 d; P > 0.05) in treatment group compared to control group. VD level had no significant association with mortality(P > 0.05). In multivariate analysis, treatment with VD supplement was found significantly(P < 0.05; adjusted hazard ratio: 0.48) associated with survival of the patients over 6-mo. CONCLUSION VD deficiency is very common in patients of decompensated CLD. Replenishment of VD may improve survival in patients with decompensated liver cirrhosis. | Ashish Kumar Jha Sharad Kumar Jha Amarendra Kumar Vishwa Mohan Dayal Sanjeev Kumar Jha | 2017 | World Journal of Gastrointestinal Pathophysiology2017，8，3： | 2 |
| 4 | A comprehensive review on material selection for polymer matrix composites subjected to impact load显示文摘Polymer matrix composites(PMC)are extensively been used in many engineering applications.Various natural fibers have emerged as potential replacements to synthetic fibers as reinforcing materials composites owing to their fairly better mechanical properties,low cost,environment friendliness and biodegradability.Selection of appropriate constituents of composites for a particular application is a tedious task for a designer/engineer.Impact loading has emerged as the serious threat for the composites used in structural or secondary structural application and demands the usage of appropriate fiber and matrix combination to enhance the energy absorption and mitigate the failure.The objective of the present review is to explore the composite with various fiber and matrix combination used for impact applications,identify the gap in the literature and suggest the potential naturally available fiber and matrix combination of composites for future work in the field of impact loading.The novelty of the present study lies in exploring the combination of naturally available fiber and matrix combination which can help in better energy absorption and mitigate the failure when subjected to impact loading.In addition,the application of multi attributes decision making(MADM)tools is demonstrated for selection of fiber and matrix materials which can serve as a benchmark study for the researchers in future. | Vishwas Mahesh Sharnappa Joladarashi Satyabodh M.Kulkarni | 2021 | Defence Technology(防务技术)2021，17，1： | 2 |
| 5 | Neurological manifestations of hepatitis E virus infection:An overview显示文摘Hepatitis E virus(HEV)is an important cause of repeated waterborne outbreaks of acute hepatitis.Recently,several extrahepatic manifestations(EHMs)have been described in patients with HEV infection.Of these,neurological disorders are the most common EHM associated with HEV.The involvement of both the peripheral nervous system and central nervous system can occur together or in isolation.Patients can present with normal liver function tests,which can often be misleading for physicians.There is a paucity of data on HEV-related neurological manifestations;and these data are mostly described as case reports and case series.In this review,we analyzed data of 163 reported cases of HEV-related neurological disorders.The mechanisms of pathogenesis,clinico-demographic profile,and outcomes of the HEV-related neurological disorders are described in this article.Nerve root and plexus disorder were found to be the most commonly reported disease,followed by meningoencephalitis. | Ashish Kumar Jha Gaurav Kumar Vishwa Mohan Dayal Abhay Ranjan Arya Suchismita | 2021 | World Journal of Gastroenterology2021，27，18： | 2 |
| 6 | Ripening of fleshy fruit: Molecular insight and the role of ethylene显示文摘 | Vishwas A. Bapat Prabodh K. Trivedi Antara Ghosh Vidhu A. Sane Thumballi R. Ganapathi Pravendra Nath | 2009 | Biotechnology Advances2009，，1： | 2 |
| 7 | Photocatalytic degradation for environmental applications:a review显示文摘 | Dhananjay S Bhatkhande Vishwas G Pangarkar Anthony ACM Beenackers | 2001 | Journal of Chemical Technology and Biotechnology2001，77，2： | 1 |
| 8 | Yoga techniques as a means of core stability training 显示文摘 | Omkar SN Vishwas S Tech B | 2009 | J Bodyw Mov Ther2009，13，1： | 1 |
| 9 | Evaporative heat transfer to solutions containing dissolved solids: Effect of vapour-liquid equilibrium and mass transfer 显示文摘 | Vishwas V Wadekar Peter D Hills | 2001 | Chemical Engineering Research & Design2001，79，4： | 1 |
| 10 | Synthesis and in vitro eval- uation of melatonin entrapped PLA nanoparticles: An oxidative stress and T-cell response using golden hamster 显示文摘 | Pandey SK Haldar C Vishwas DK | 2015 | J Biomed Mater Res A2015，103，9： | 1 |
| 11 | Photocatalytic degradation for environmental applications-a review 显示文摘 | Bhatkhande Dhananjay S Pangarkar Vishwas G Beenackers Anthony A C M | 2001 | Journal of Chemical Technology and Biotechnology2001，77，： | 1 |
| 12 | Solar-assisted Photoeatalytie Degradation of Phenol显示文摘 | Arehis A Yawalkar Dhananjay S Vishwas G | 2001 | Chemical Tehnology and Biotechnology2001，76，： | 1 |
| 13 | Current status of TB vaccines显示文摘 | Umesh Datta Gupta Vishwa Mohan Katoch David N. McMurray | 2007 | Vaccine2007，，19： | 1 |
| 14 | Yoga techniques as a means of core stability training显示文摘 | Omkar SN Vishwas S Tech B | 2009 | J Bodyw Mov Ther2009，13，1： | 1 |
| 15 | Towards a data publishing framework for primary biodiversity data : chal- lenges and potentials for the biodiversity informatics commu- nity显示文摘 | Vishwas S Chavan and Peter Ingwersen | 2009 | BMCBioinformatics2009，10，14： | 1 |
| 16 | Absorption of sulfur dioxide into aqueous reactive slurries of calcium and magnesium hydroxide in a stirred cell显示文摘 | Manoj V D Antonie A C M B Vishwas G P | 2001 | Chemical Engineering Science2001，56，3： | 1 |
| 17 | Roles of molecular chaperones in cytoplasmic protein folding显示文摘 | Vishwas R Agashe F Hartl U | 2000 | Cell & Developmental Biology2000，11，： | 1 |
| 18 | Coating of nanosize silver particles with silica显示文摘 | Vishwas V Hardikar Egon Matijevic | 2002 | Colloid Interface Sci2002，221，1： | 1 |
| 19 | Degradation analysis of Reactive Red 198 by hairy roots of Tagetes patula L. (Marigold)显示文摘 | Pratibha Patil Neetin Desai Sanjay Govindwar Jyoti Prafulla Jadhav Vishwas Bapat | 2009 | Planta2009，，4： | 1 |
| 20 | 显示文摘 | Dhananjay S B Vishwas G P Anthony A B | 2001 | J Chem Tech Blot2001，77，： | 1 |
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