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| 1 | Diffusion weighted imaging: Technique and applications显示文摘Diffusion weighted imaging(DWI) is a method of signal contrast generation based on the differences in Brownian motion. DWI is a method to evaluate the molecular function and micro-architecture of the human body. DWI signal contrast can be quantified by apparent diffusion coefficient maps and it acts as a tool for treatment respon-se evaluation and assessment of disease progression. Ability to detect and quantify the anisotropy of diffusion leads to a new paradigm called diffusion tensor imaging(DTI). DTI is a tool for assessment of the organs with highly organised fibre structure. DWI forms an integral part of modern state-of-art magnetic resonance imaging and is indispensable in neuroimaging and oncology. DWI is a field that has been undergoing rapid technical evolution and its applications are increasing every day. This review article provides insights in to the evolution of DWI as a new imaging paradigm and provides a summary of current role of DWI in various disease processes. | Vinit Baliyan Chandan J Das Raju Sharma Arun Kumar Gupta | 2016 | World Journal of Radiology2016，8，9： | 18 |
| 2 | Neuroretinal hypoxic signaling in a new preclinical murine model for proliferative diabetic retinopathy显示文摘Diabetic retinopathy(DR)affects approximately one-third of diabetic patients and,if left untreated,progresses to proliferative DR(PDR)with associated vitreous hemorrhage,retinal detachment,iris neovascularization,glaucoma and irreversible blindness.In vitreous samples of human patients with PDR,we found elevated levels of hypoxia inducible factor 1 alpha(HIF1α).HIFs are transcription factors that promote hypoxia adaptation and have important functional roles in a wide range of ischemic and inflammatory diseases.To recreate the human PDR phenotype for a preclinical animal model,we generated a mouse with neuroretinal-specific loss of the von Hippel Lindau tumor suppressor protein,a protein that targets HIF1αfor ubiquitination.We found that the neuroretinal cells in these mice overexpressed HIF1αand developed severe,irreversible ischemic retinopathy that has features of human PDR.Rapid progression of retinopathy in these mutant mice should facilitate the evaluation of therapeutic agents for ischemic and inflammatory blinding disorders.In addition,this model system can be used to manipulate the modulation of the hypoxia signaling pathways,for the treatment of non-ocular ischemic and inflammatory disorders. | Katherine J Wert Vinit B Mahajan Lijuan Zhang Yuanqing Yan Yao Li Joaquin Tosi Chun Wei Hsu Takayuki Nagasaki Kerstin M Janisch Maria B Grant MaryAnn Mahajan Alexander G Bassuk Stephen H Tsang | 2016 | Signal Transduction and Targeted Therapy2016，1，1： | 1 |
| 3 | Repression of calcitonin gene-relat- ed peptide expression in trigeminal neurons by atheobroma cacao ex- tract 显示文摘 | Marcie J Abbey V Vinit V | 2008 | Ethnophar-maeo12008，115，2： | 1 |
| 4 | Heart involvement in ChurgStrauss syndrome: retrospective study in French Burgundy population in past 10 years显示文摘 | Vinit J Bielefeld P Muller G | 2010 | Eur J Intern Med2010，21，4： | 1 |
| 5 | Churg-Strauss syn- drome: retrospective study in Burgundian population in France in past 10 years 显示文摘 | Vinit J Muller G Bielefeld P | 2011 | Rheumatol Int2011，31，： | 1 |
| 6 | Churg-Strauss syndrome: retrospective study in Burgundian population in France in past 10 years 显示文摘 | Vinit J Muller G Bielefeld P | 2011 | Rheumatol Int2011，31，5： | 1 |
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