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| 1 | Fracture mechanisms in soft rock: Identification and quantification of evolving displacement discontinuities by extended digital image correlation显示文摘 | Tuong Lam Nguyen Stephen A. Hall Pierre Vacher Gioacchino Viggiani | 2010 | Tectonophysics2010，，1： | 2 |
| 2 | Systematic review: Renin-angiotensin system inhibitors in chemoprevention of hepatocellular carcinoma显示文摘BACKGROUND Neoangiogenesis is one of the key pathogenetic mechanisms in hepatocellular carcinoma (HCC). Modulation of the renin-angiotensin system (RAS) by angiotensin-converting enzyme inhibitors (ACE-Is) and angiotensin receptor blockers (ARBs) seems to be a possible adjuvant therapy for HCC, due to the antiangiogenic and anti-fibrogenic activity of these drugs. AIM To elucidate the role of ARBs and ACE-Is in HCC. METHODS We performed an electronic search of the literature using the most accessed online databases (PubMed, Cochrane library, Scopus and Web of Science), entering the query terms 'angiotensin-converting enzyme inhibitors' OR 'ACE inhibitors' OR 'ACE-I' AND 'hepatocarcinoma*' OR 'hepatocellular carcinoma;moreover 'angiotensin II type 1 receptor blockers' OR 'ARBs' AND 'hepatocarcinoma*' OR 'hepatocellular carcinoma'. Eligibility criteria were:(1) prospective or retrospective clinical studies;(2) epidemiological studies;and (3) experimental studies conducted in vivo or in vitro. Abstracts, conference papers, and reviews were excluded a priori. We limited our literature search to articles published in English, in peer-reviewed journals.RESULTS Thirty-one studies were selected. Three interventional studies showed that ACEIs had a significant protective effect on HCC recurrence only when used in combination with vitamin K or branched chain aminoacids, without a significant increase in overall survival. Of six retrospective observational studies, mainly focused on overall survival, only one demonstrated a prolonged survival in the ACE-Is group, whereas the two that also evaluated tumor recurrence showed conflicting results. All experimental studies displayed beneficial effects of RAS inhibitors on hepatocarcinogenesis. Numerous experimental studies, conducted either on animals and cell cultures, demonstrated the anti-angiogenetic and antifibrotic effect of ACE-Is and ARBs, thanks to the suppression of some cytokines such as vascular endothelial growth factor, hypoxia-inducible factor-1a, transforming growth factor-beta and tumor necrosis factor alpha. All or parts of these mechanisms were demonstrated in rodents developing fewer HCC and preneoplastic lesions after receiving such drugs. CONCLUSION In humans, RAS inhibitors - alone or in combination - significantly suppressed the cumulative HCC recurrence, without prolonging patient survival, but some limitations intrinsic to these studies prompt further investigations. | Michele Barone Maria Teresa Viggiani Giuseppe Losurdo Mariabeatrice Principi Alfredo Di Leo | 2019 | World Journal of Gastroenterology2019，25，20： | 2 |
| 3 | Evaluation of different strategies for the integration of hypoplastic constitutive equations: Application to the CLoE model显示文摘 | TAMAGNINI C VIGGIANI G CHAMBON R | 2000 | Mechanics of Cohesive-Frictional Materials2000，5，4： | 1 |
| 4 | Numerical modelling of installation effects for diaphragm walls in sand 显示文摘 | Conti R de Sanctis L Viggiani G M B | 2012 | Acta Geotechnica2012，7，3： | 1 |
| 5 | Monitoring fracture propagation in a soft rock(Neapolitan Tuff) using acoustic emissions and dig- ital images显示文摘 | STEPHEN A HALL FIORENZA de SANCTIS GIOAC- CHINO VIGGIANI | 2006 | Pure appl Geo Phys2006，163，10： | 1 |
| 6 | HE4:a new potential early biomarker for the recurrence of ovarian cancer显示文摘 | Anastasi E Marchei G G Viggiani V | 2010 | Tumour Biol2010，31，2： | 1 |
| 7 | The classification of the Trichogrammatidae (Hymenoptera: Chalcidoidea)显示文摘 | DOUTI' R L VIGGIANI G | 1968 | PmceediDlgs of the California Academy of Sciences1968，35，： | 1 |
| 8 | The increase of insect pests in Eu- calyptus显示文摘 | VIGGIANI G LAUDONIA S BERNAR -DO U | 2000 | InfAgr2000，58，12： | 1 |
| 9 | X-ray microtomography for studying localized deformation in fine-grained geomaterials under triaxial compression显示文摘 | VIGGIANI G LENOIR N BESUELLE P | 2004 | C R Mecanique2004，332，： | 1 |
| 10 | An airlift biofilm reactor for the biodegradation of phenol by Pseudomonas stutzeri OX1 显示文摘 | VIGGIANI A OLIVIERI G SIANI L | 2006 | Bioteehnology2006，123，10： | 1 |
| 11 | Multiscale modeling and characterization of granular matter: From grain kinematics to continuum mechanics显示文摘 | J.E. Andrade C.F. Avila S.A. Hall N. Lenoir G. Viggiani | 2010 | Journal of the Mechanics and Physics of Solids2010，，2： | 1 |
| 12 | Stiffness of fine-grained soils at very small strains显示文摘 | VIGGIANI G ATK1NSON J H | 1995 | Geotechnique1995，45，2： | 1 |
| 13 | Pile foundation analysis: a simple approach to non linearity effects 显示文摘 | Caputo V Viggiani C | 1984 | Rivista Italiana di Feotecnica1984，18，2： | 1 |
| 14 | A unique critical state for sand显示文摘 | Finno R J Viggiani M G | 1998 | J of Geotechnical and Geoenvironmental Engineering ASCE1998，124，11： | 1 |
| 15 | Stiffness of fine-grained soil at very small strains显示文摘 | VIGGIANI G ATKINSON J H | 1995 | Geotechnique1995，45，2： | 1 |
| 16 | Interpretation of bender element tests显示文摘 | GIULIA VIGGIANI AATKINSON J H | 1997 | Geotechnique1997，45，1： | 1 |
| 17 | Stiffness of Fine-grained Soils at Very Small Strains显示文摘 | Viggiani G and Atkinson J H | 1995 | Geotechnique1995，45，24： | 1 |
| 18 | HE4: a new potential early biomarker for the recurrence of ovarian cancer显示文摘 | Anastasi E Marchei GG Viggiani V | 2010 | Tumour Biol2010，31，2： | 1 |
| 19 | An assessment of plasticity theories for modeling the incrementally nonlinear behavior of granular soils显示文摘 | TAMAGNINI C CALVETTI F VIGGIANI G | 2005 | Journal of Engineering Mathemat ics2005，52，13： | 1 |
| 20 | HE4: a new potential early biomarker for the recurrence of ovarian cancer显示文摘 | Anastasi E Marchei GG Viggiani V | 2010 | Tumour Binl2010，31，2： | 1 |
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