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| 1 | Evaluation of VEGF gene polymorphisms and proliferative diabetic retinopathy in Mexican population显示文摘● AIM: To assess if the included vascular endothelial growth factor(VEGF) polymorphisms rs3025035, rs3025021 and rs2010963 are associated to proliferative retinopathy in a Mexican population with type 2 diabetes mellitus(T2DM).● METHODS: A case-control study was conducted in adult individuals with T2 DM associated to proliferative retinopathy or non-proliferative retinopathy from Oct. 2014 to Jun. 2015 from the Retina Department of the Asociation to Prevent Blindness in Mexico. The selected patients were adults with a diagnosis of T2 DM ≥5y. All subjects had a comprehensive ocular examination and the classification of the retinopathy severity was made considering the Early Treatment Diabetic Retinopathy Study(ETDRS) standardization protocols. Genomic DNA was extracted from whole fresh blood. All samples were genotyped by q PCR for selected VEGF polymorphisms. Hardy-Weinberg equilibrium was calculated by comparing Chi-square values between the expected and the observed values for genotype counts.● RESULTS: In total 142 individuals were enrolled, 71 individuals with T2 DM and associated proliferative retinopathy and 71 individuals with non-proliferative retinopathy. One-sided Fisher's exact test was performed for rs3025021[OR(95% CI)=0.44(0.08-2.2); P=0.25] and rs2010963 [OR(95% CI)=0.63(0.25-1.6); P=0.23]. The minor allelic frequencies obtained were 26% for rs3025021, 10% for rs3025035 and 61% for rs2010963. The pairwise linkage disequilibrium between the three SNP was assessed, and was as follows: rs3025021 vs rs3025035: D'=1.0, r^2=0.1043, P≤0.0001; rs3025021 vs rs2010963: D'=0.442, r^2=0.0446, P=0.149; rs3025035 vs rs2010963: D'=0.505, r^2=0.0214, P=0.142.● CONCLUSION: This is the first analysis involving VEGFA polymorphisms and proliferative diabetic retinopathy in a Mexican population. A major finding of the present study is that none of the polymorphisms studied was significantly associated with proliferative retinopathy. Based on these results, we can infer that different populations have different associations for the same polymorphisms. | Roberto Gonzalez-Salinas Maria C Garcia-Gutierrez Gerardo Garcia-Aguirre Virgilio Morales-Canton Raul Velez-Montoya Vidal R Soberon-Ventura Victoria Gonzalez Rodrigo Lechuga Pablo Garcia-Solis David G Garcia-Gutierrez Marco Vinicio Garcia-Solis Manuel Saenz de Viteri Juan C Solis-S | 2017 | International Journal of Ophthalmology(English edition)2017，10，1： | 12 |
| 2 | Dual Peroxisome Proliferator–Activated Receptor α/δ Agonist GFT505 Improves Hepatic and Peripheral Insulin Sensitivity in Abdominally Obese Subjects显示文摘 | Bertrand Cariou Rémy Hanf Stéphanie Lambert-Porcheron Yassine Za?r Valérie Sauvinet Benoit No?l Laurent Flet Hubert Vidal Bart Staels Martine Laville | 2013 | Diabetes Care2013，，10： | 2 |
| 3 | K nearest neighbours with mutual information for simultaneous classification and missing data imputation显示文摘 | Garcia-Laencina P J Saneho-Gomez J-L Figueiras Vidal A R | 2009 | Neurocomputing2009，72，79： | 1 |
| 4 | Synthesis of utility systems by simulated显示文摘 | Maia L O A Vidal L A Qassim R Y | 1995 | Comp & Chem Eng1995，19，： | 1 |
| 5 | 5-azacitidine prolongs overall survival in patients with myelodysplastic syndrome-a systematic review and meta-analysis 显示文摘 | Gurion R Vidal L Gafter-Gvili A | 2010 | Haematotogica2010，95，2： | 1 |
| 6 | Identification of Hake species (Merluccius Genus) using sequencing and PCR-RFLP analysis of mitochondrial DNA con- trol region sequences显示文摘 | Quinteiro J Vidal R Izquierdo M | 2001 | J Agric Food Chem2001，49，11： | 1 |
| 7 | Synthesis of utility systems with variable demands using simulated annealing显示文摘 | Maia L O A Vidal L A Qassim R Y | 1997 | Comp & Chem Eng1997，21，： | 1 |
| 8 | Population based drug induce dagranu loeytosis显示文摘 | Vidal X Ballarin E Laporte J R | 2005 | ArchIntern Med2005，165，： | 1 |
| 9 | The LuxS- dependent quorum sensing system regulates early biofilm formation by Streptococcus pneumoniae strain D39显示文摘 | Vidal J E Ludewick H P Kunkel R M | 2011 | Infect Immun2011，79，10： | 1 |
| 10 | Compartment syndromefollowing intraosseous infusion 显示文摘 | Vidal R Kissoon N Gayle M | 1993 | Pediatrics1993，91，6： | 1 |
| 11 | Influence of the content in fats and proteins on the anaerobic biodegradability of dairy wastewaters显示文摘 | Vidal G Carvlho A Mndez R | 2000 | Bioresource Technology2000，74，： | 1 |
| 12 | Phosphoenolpyruvate earboxylase:a ubiquitous,highly regulated enzyme in plants显示文摘 | Chollet R Vidal J O'Leary M H | 1996 | Ann Rer Plant Physiol Plant Mol Biol1996，47，： | 1 |
| 13 | Determination of total and pancreatic a-amylase in human serum with 2-chloro-4-nitropyenl-α-D-maltotrisoide as substrate 显示文摘 | Gella F Gubern G Vidal R | 1997 | Clin Chim Acta1997，259，： | 1 |
| 14 | Galloyl moieties enhance the dentin biomodification potential of plant-derived catechins 显示文摘 | Vidal CM Aguiar TR Phansalkar R | 2014 | Acta Biomater2014，10，7： | 1 |
| 15 | Active infective endocarditis : 152 cases显示文摘 | Kazelian LR Vidal LA Neme R | 2012 | Medicina (B Aires)2012，72，2： | 1 |
| 16 | Analyzing crack width to predict corrosion in reinforced concrete 显示文摘 | Vidal T Castel A Francois R | 2004 | Cement and Concrete Research2004，34，1： | 1 |
| 17 | Delay from fracture tohospital admission: a new risk factor for hip fracture mortality 显示文摘 | Vidal E Moreira-Filho D Pinheiro R | 2012 | Osteoporos Int2012，23，12： | 1 |
| 18 | Dynamic template Track- ing and recognition显示文摘 | Chaudhry R Hager G Vidal R | 2013 | International Journal Of Computer Vision2013，105，1： | 1 |
| 19 | Analysis of the stress state at the cogging joint in timber structures显示文摘 | Vliiar J R Guaita M Vidal P | 2007 | Biosystems engineering2007，96，1： | 1 |
| 20 | PHOSPHOENOLP- YRUVATE CARBOXYLASE: AUbiquitous, Highly Regulated Enzyme in Plants 显示文摘 | Chollet R Vidal J O'Leary M H | 1996 | Plant Mol Biol1996，47，： | 1 |
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