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| 1 | Helicobacter pylori and EBV in gastric carcinomas:Methylation status and microsatellite instability显示文摘AIM:To verify the methylation status of CDH1, DAPK, COX2, hMLH1 and CDKN2A genes and to evaluate their association with Helicobacter pylori (H. pylori)-cagA+ and Epstein Barr virus (EBV) infections in gastric adenocarcinomas.METHODS: Methylation-specific PCR (MSP) assay was performed in 89 primary gastric carcinomas (intestinal and diffuse types). Microsatellite instability (MSI) analysis was performed using the BAT26 primer set and PCR products were analyzed with the ABI PRISM 3100 Genetic Analyzer using Genescan 3.7 software (Applied Biosystems). Detection of H. pylori and genotyping were performed by PCR, using specifi c primers for ureaseC and cagA genes. The presence of EBV was assessed by in situ hybridization. Statistical analyses were performed using the χ2 or Fisher's exact test.RESULTS: The most frequent hypermethylated gene was COX-2 (63.5%) followed by DAPK (55.7%), CDH1 (51%), CDKN2A (36%) and hMLH1 (30.3%). Intestinal and diffuse adenocarcinomas showed different methylation profiles and there was an association between methylation of E-CDH1 and H. pylori-cagA+ in the intestinal adenocarcinoma type. MSI was correlated with hMLH1 methylation. There was an inverse correlation between DAPK hypermethylation and MSI.CONCLUSION: We found a strong association between CDH1 methylation and H. pylori-cagA+ in intestinal-type gastric cancer, association of MSI and better prognosis and an heterogeneous COX-2 overexpression. | Adriana Camargo Ferrasi Nídia Alice Pinheiro Silvia Helena Barem Rabenhorst Otávia Luisa Caballero Maria Aparecida Marchesan Rodrigues Fabrício de Carvalho Celso Vieira de Souza Leite Marcia Valéria Pitombeira Ferreira Marcos Aurélio Pessoa Barros Maria Inês de Moura Campos Pardini | 2010 | World Journal of Gastroenterology2010，16，3： | 6 |
| 2 | Embolization of splenorenal shunt associated to portal vein thrombosis and hepatic encephalopathy显示文摘Hepatic encephalopathy(HE)is a cognitive disturbance characterized by neuropsychiatric alterations.It occurs in acute and chronic hepatic disease and also in patients with portosystemic shunts.The presence of these portosystemic shunts allows the passage of nitrogenous substances from the intestines through systemic veins without liver depuration.Therefore,the embolization of these shunts has been performed tocontrol HE manifestations,but the presence of portal vein thrombosis is considered a contraindication.In this presentation we show a cirrhotic patient with severe HE and portal vein thrombosis who was submitted to embolization of a large portosystemic shunt.Case report:a 57 years-old cirrhotic patient who had been hospitalized many times for persistent HE and hepatic coma,even without precipitant factors.She had a wide portosystemic shunt and also portal vein thrombosis.The abdominal angiography confirmed the splenorenal shunt and showed other shunts.The larger shunt was embolized through placement of microcoils,and the patient had no recurrence of overt HE.There was a little increase of esophageal and gastric varices,but no endoscopic treatment was needed.Since portosystemic shunts are frequent causes of recurrent HE in cirrhotic patients,portal vein thrombosis should be considered a relative contraindication to perform a shunt embolization.However,in particular cases with many shunts and severe HE,we found that one of these shunts can be safely embolized and this procedure can be sufficient to obtain a good HE recovery.In conclusion,we reported a case of persistent HE due to a wide portosystemic shunt associated with portal vein thrombosis.As the patient had other shunts,she was successfully treated by embolization of the larger shunt. | Letícia de Campos Franzoni Fábio Cardoso de Carvalho Rafael Gomes de Almeida Garzon Fábio da Silva Yamashiro Laís Augusti Lívia Alves Amaral Santos Mariana de Souza Dorna Júlio Pinheiro Baima Talles Bazeia Lima Carlos Antonio Caramori Giovanni Faria Silva Fernando Gomes Romeiro | 2014 | World Journal of Gastroenterology2014，20，42： | 6 |
| 3 | Adaptive phenotypic plasticity : consensus and controversy 显示文摘 | Via S Gomulkiewicz R De Jong G | 1995 | Trends in Ecology and Evolution1995，5，： | 1 |
| 4 | Expression of CD28,CTLA4,CD80,and CD86 molecules in patients with autoimmune rheumatic diseases:implications for immunotherapy显示文摘 | Sfikakis P P Via C S | 1997 | Clin Immunol Immunopath1997，83，3： | 1 |
| 5 | HMG-CoA reduetase inhibitors reduce MMP-9 secretion by macrophages显示文摘 | Bellota S Via D Canavesi M | 1998 | Arteroseler Thlomb Vasc Biol1998，18，11： | 1 |
| 6 | Processing and storage effects on anthocyanin composition and antioxidant activity of jams produced with C amarosa strawberry显示文摘 | Luís F. Amaro M. Teresa Soares Carina Pinho Isabel F. Almeida Olívia Pinho Isabel M. P. L. V. O. Ferreira | 2013 | Int J Food Sci Technol2013，，10： | 1 |
| 7 | Gustatory perception alterations in obesity: An fMRI study显示文摘 | Csaba Szalay Mihály Aradi Attila Schwarcz Gergely Orsi Gábor Perlaki Lívia Németh Sophia Hanna Gábor Takács István Szabó László Bajnok András Vereczkei Tamás Dóczi József Janszky Sámuel Komoly Péter ?rs Horváth László Lénárd Zoltán Karadi | 2012 | Brain Research2012，，： | 1 |
| 8 | HM G2COA reductase inhibitons reduce MM P29 secretion by macrophages显示文摘 | Bellosta S Via D Canavesi M | | 0，，： | 1 |
| 9 | Influence of surface morphology of the kraft pulp fibers on the growth of the transcrystalline layer of polypropylene 显示文摘 | Lee B G Lee S Via B K | 2010 | J Appl Polym Sci2010，116，4： | 1 |
| 10 | Nationwide assessment of 显示文摘 | Russell CG Blute NK Via S et nitrosamine occurrence and trends al | 2012 | J Am Water Works Ass2012，104，： | 1 |
| 11 | Localizing FST outliers on a QTL map reveals evidence for large genomic regions of reduced gene exchange during speciation-with-gene-flow显示文摘 | Via S Conte G Mason-Foley C Mills K | | 0，，： | 1 |
| 12 | In vivo proton magnetic resonance spectroscopy of diseased prostate: spectroscopic features of malignant versus benign pathology显示文摘 | J.M García-Segura M Sánchez-Chapado C Ibarburen J Via?o J.C Angulo J González J.M Rodríguez-Vallejo | 1999 | Magnetic Resonance Imaging1999，，5： | 1 |
| 13 | Ultrasound for 'lung monitoring' of ventilated patients 显示文摘 | Bouhemad B Mongodi S Via G | 2015 | Anesthesiol- ogy2015，122，2： | 1 |
| 14 | HMG - CoA reductase inhibitors reduce MMP - 9 Secretion by macrophages显示文摘 | Bellosta S Via D Canavesi M | 1998 | Arterioscler Thromb Vasc Biol1998，18，： | 1 |
| 15 | HMG-CoA recuctase inhibitors reduce MMP-9 secretionby macrophages显示文摘 | Bellosta S Via D Canavesi M | 1998 | Arterioscler Thromb Vasc Biol1998，18，11： | 1 |
| 16 | Usefulness of combined bedside lung ultrasound and echocardiography to assess weaning failure from mechanical ventilation: a suggestive case 显示文摘 | Mongodi S Via G Bouhemad B | 2013 | Crit CareMed2013，41，8： | 1 |
| 17 | Chronic low frequency electrical activation for one week corrects nerve conduction velocity deficits in rats with diabetes of three months duration 显示文摘 | Cameron NE Cotter/VIA Robertson S | 1989 | Diabetologia1989，32，10： | 1 |
| 18 | Detection of bovine babesiosis in Mozambique by a novel seminested hot-start PCR method显示文摘 | Tiago M. Martins Olívia C. Pedro Rubina A. Caldeira Virgílio E. do Rosário Luís Neves Ana Domingos | 2008 | Veterinary Parasitology2008，，3： | 1 |
| 19 | HMG- CoA reductase inhibitors reduce MMP- 9 secretion by macrophages显示文摘 | Bellosta S Via D Canavesi M | 1998 | Arterioscler Thromb Vase Biol1998，18，11： | 1 |
| 20 | Adaptive phenotypic plasticity: Consensus and Controversy显示文摘 | Via S Gomulkiewicz R Jong D G | 1995 | Tree1995，10，5： | 1 |
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