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    题名 作者 年代 出处 被引量
1The intersection of genetic and chemical genomic screens identifies GSK-3[alpha] as a target in human acute myeloid leukemia显示文摘Banerji Versha Frumm Stacey M Ross Kenneth N Li Loretta S Schinzel Anna C Hahn Cynthia K Kakoza Rose M Chow Kwan T Ross Linda Alexe Gabriela Tolliday Nicola Inguilizian Haig Galinsky Ilene Stone Richard M DeAngelo Daniel J Roti Giovanni As 2012EN2012,,3:1
2Lysophosphatidic acid (LPA) induces the expression of VEGF leading to protection against apoptosis in B-cell derived malignancies显示文摘Xiaojie Hu Francisco J. Mendoza Jinmie Sun Versha Banerji James B. Johnston Spencer B. Gibson 2008Cellular Signalling2008,,6:1
3印度经济法显示文摘译者的话本文节选自印度法学会(The Indian Law Institution,简称ILI)组织各方法律人士撰写、出版的论文集《印度法律制度》(Indian Legal System)第二版。本书由已故教授Joseph Minattur主编,1978年发行第一版。其后,随着印度立法和司法改革的推进,旧作相关内容需要增删。为此,印度法学会再次组织人手,对除'印度法院史和立法机关史'之外的章节进行修订,并于2006年出版第二版。M.P.Jain Versha Vahini(校) 宋彪(编译) 2013经济法学评论2013,,1:0
4Comparative assessment for removal of anionic dye from water by different waste-derived biochar vis a vis reusability of generated sludge显示文摘In this study,four biochars prepared from different crop residue waste i.e.sugarcane bagasse(SBB),coconut shell(CNB),paddy straw(PDB),and distilled waste of lemongrass(LGB)were evaluated for removal of Remazol Brilliant Blue R from the aqueous system.The RBBR adsorption capacities of biochar were 97-79%for SBB,99.9-99.47%for CNB,66.1-48%for PDB,and 78-68%for LGB,dominantly controlled by their aromaticity and mineral content.The Langmuir and Freundlich isotherms and pseudo-second-order kinetic models have described the chemisorption of RBBR on biochar surfaces.The thermodynamic data suggested that adsorption was spontaneous and endothermic.These biochars demonstrated excellent reusability(till four cycles with 50-61%regeneration).The purified water and biochar dye sludge demonstrated no phytotoxicity.The findings obtained in this study may provide supports for the potential of biochars for anionic dye removal from water and utilization of generated sludge for zero waste-producing technologies in the future.Mayank Singh MohdAhsan Versha Pandey Anupama Singh Disha Mishra Neerja Tiwari Pooja Singh Tanmoy Karak Puja Khare 2022Biochar2022,4,1:0
5Anti-cancer effects of sitagliptin,vildagliptin,and exendin-4 on triple-negative breast cancer cells via mitochondrial modulation显示文摘Triple-negative breast cancer(TNBC)cell line MDA-MB-231 is known for Warburg metabolism and defects in mitochondria.On the other hand,dipeptidyl peptidase-IV(DPP-IV)inhibitors such as sitagliptin and vildagliptin and GLP-1 agonist exendin-4 are known to improve mitochondrial functions as well as biogenesis,but no study has evaluated the influence of these drugs on mitochondrial biogenesis on metastatic breast cancer cell line.We have recently reported anticancer effects of 5-aminoimidazole-4-carboxamide riboside on MDA-MB-231 cells via activation of AMP-dependent kinase(AMPK),which activates the downstream transcription factors PGC-1α,PGC-1β,or FOXO1 for mitochondrial biogenesis;above-mentioned incretin-based therapies are also known to activate AMPK.This study evaluated the effects of sitagliptin,vildagliptin,and exendin-4 on MDA-MB-231 cells and the underlying changes in mitochondrial biogenesis,were examined.Treatment with sitagliptin(100μM),vildagliptin(100μM),and exendin-4(10 nM)for 72 h to MDA-MB-231 cells led to a decrease in viability indicated by MTT assay,cell migration by scratch,and transwell migration assays,accompanied with marginal reduction in cell numbers along with the apoptotic appearance,the rate of apoptosis,and decreased lactate content in conditioned medium.These changes in the cancer phenotype were accompanied by an increase in the mitochondrial DNA to nuclear DNA ratio,increased MitoTracker green and red staining,and increased expression of transcription factors PGC-1α,NRF-1,NRF-2,TFAM,and HO-1.Pre-treatment of cells with these incretin-based drugs followed by 48 h treatment with 1μM doxorubicin increased doxorubicin sensitivity as observed by a decrease in viability by MTT assay.Thus,sitagliptin,vildagliptin,and exendin-4 exert their beneficial effects on TNBC cells via an increase in mitochondrial biogenesis that helps to switch Warburg metabolism into anti-Warburg effect.Therapeutic response was in the order of:sitagliptin>vildagliptin>exendin-4.POOJA JAISWAL VERSHA TRIPATHI ANSHUL ASSAIYA DHARMENDRA KASHYAP RAHUL DUBEY ANAMIKA SINGH JANESH KUMAR HEM CHANDRA JHA RAJESH SHARMA AMIT KUMAR DIXIT HAMENDRA SINGH PARMAR 2022BIOCELL2022,46,12:0
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