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21篇 您的检索式：作者名="Verseyden"

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	题名	作者	年代	出处	被引量
1	ATG16L1 and NOD2 polymorphisms enhance phagocytosis in monocytes of Crohn's disease patients显示文摘AIM:To investigate if the presence of relevant genetic polymorphisms has effect on the effectual clearance of bacteria by monocytes and granulocytes in patients with Crohn’s disease(CD).METHODS:In this study,we assessed the differential responses in phagocytosis by measuring the phagocytic activity and the percentage of active phagocytic monocytes and granulocytes in inflammatory bowel disease patients as well as healthy controls.As both autophagy related like 1(ATG16L1)and immunityrelated guanosine triphosphatase gene are autophagy genes associated with CD and more recently nucleo-tide-binding ligomerization domain-containing protein2(NOD2)has been identified as a potent inducer of autophagy we genotyped the patients for these variants and correlated this to the phagocytic reaction.The genotyping was done with restriction fragment length polymorphisms analysis and the phagocytosis was determined with the pHrodo?Escherichia coli Bioparticles Phagocytosis kit for flowcytometry.RESULTS:In this study,we demonstrate that analysis of the monocyte and granulocyte populations of patients with CD and ulcerative colitis showed a comparable phagocytic activity(ratio of mean fluorescence intensity)between the patient groups and the healthy controls.CD patients show a significantly higher phagocytic capacity(ratio mean percentage of phagocytic cells)compared to healthy controls(51.91%±2.85%vs 37.67%±7.06%,P=0.05).The extend of disease was not of influence.However,variants of ATG16L1(WT:2.03±0.19 vs homozygoot variant:4.38±0.37,P<0.009)as well as NOD2(C-ins)(heterozygous variant:42.08±2.94 vs homozygous variant:75.58±4.34(P=0.05)are associated with the phagocytic activity in patients with CD.CONCLUSION:Monocytes of CD patients show enhanced phagocytosis associated with the presence of ATG16L1 and NOD2 variants.This could be part of the pathophysiological mechanism resulting in the disease.	Simone CS Wolfkamp Caroline Verseyden Esther WM Vogels Sander Meisner Kirsten Boonstra Charlotte P Peters Pieter CF Stokkers Anje A te Velde	2014	World Journal of Gastroenterology2014，20，10：	2
2	Effects of atorvastatin on fasting and postprandial complement component 3 response in familial combined hyperlipidemia显示文摘	VERSEYDEN C MEIJSSEN S van DIJK H	2003	J Lipid Res2003，44，11：	1
3	Postprandial recmitment of neutrophils may contribute to endothelial dysfunction显示文摘	Van Ostrom AJ Sijmonsma TP Verseyden C	2003	J Lipid Res2003，44，：	1
4	Haematopoietic stem cells and endothelial progenitor cells in healthy men: effect of aging and training 显示文摘	Thijssen DH Vos JB Verseyden C	2006	Aging Cell2006，5，6：	1
5	Fibrin and activated platelets cooperatively guide stem cells to a vascular injury and promote differentiation towards an endothelial cell phenotype显示文摘	de Boer HC Verseyden C Ulfman LH	2006	Arterioscler Thromb Vasc Biol2006，26，7：	1
6	Postprandial recruitment of neutrophils may contribute to endothelial dysfunction显示文摘	Van-Oostrom A J Sijmonsma T P Verseyden C	2003	J Lipid Res2003，44，3：	1
7	Delayed and exaggerat- ed postprandial complement component 3 response in familial com- bined hyperlipidemia 显示文摘	Meijssen S van-Dijk H Verseyden C	2002	Arterioscler Thromb Vasc Biol2002，22，5：	1
8	Haematopoietic stem cells and endothelial progenitor cells in healthy men:effect of aging and training显示文摘	Thijssen DHJ Vos JB Verseyden C		0，，：	1
9	Delayed and exaggerated postprandial complement component 3 response in familial combined hyperlipidemia显示文摘	Meijssen S van Dijk H Verseyden C Erkelens DW Cabezas MC	2002	Arterioscler Thromb Vasc Biol2002，22，5：	1
10	Delayed and exaggerated postprandial complement component 3 response in familial combined hyperlipidemia显示文摘	Meijssen S van Dijk H Verseyden C	2002	Arterioscler Thromb Vasc Biol2002，22，：	1
11	Delayed and exaggerated postprandial complement component 3 response in familial combined hyperlipidemia显示文摘	Meijssen S van Dijk H Verseyden C	2002	Arterioscler Thromb Vasc Biol2002，22，5：	1
12	Fibrin and activa- ted platelets cooperatively guide stem cells to a vascular injury and promote differentiation towards an endothelial cell phenotype 显示文摘	de Boer HC Verseyden C Ulfman LH	2006	Arterioscler Thromb Vase Biol2006，26，7：	1
13	Fibrin and Activated Platelets Cooperatively Guide Stem Ceils to a Vascular Injury and Promote Differentiation Towards an Endothelial Cell Phenotype显示文摘	H C de Boer C Verseyden L H Ulfman	2006	Arterioscler Thromb Vasc Bio12006，26，：	1
14	Postprandial recruitment of neutrophils may contribute to endothelial dysfunction显示文摘	van Oostrom AJ Sijmonsma TP Verseyden C Jansen EH de Koning EJ Rabelink TJ	2003	J Lipid Res2003，44，：	1
15	Delaye and exaggerated postprandial complement component 3 response in familial combined hyperlipidemia显示文摘	Meijssen S Van Dijk H Verseyden C	2002	Arterioscler Thromb Vase Biol2002，22，5：	1
16	Effects of atorvastatin on fasting and postprandial complement component 3 response in familial combined hyperlipidemia显示文摘	Verseyden C Meijssen S van Dijk H	2003	J Lipid Res2003，44，：	1
17	Postprandial recruitment of neutrophils may contribute to endothelial dysfunction显示文摘	van Oostrom AJ Sijmonsma TP Verseyden C	2003	J Lipid Res2003，44，3：	1
18	Haematopoietic stem ceils and endothelial progenitor ceils in healthy men: effect of aging and training显示文摘	Thijssen DH Vos JB Verseyden C van Zonneveld AJ Smits P Sweep FC Hopman MT de Boer HC	2006	Aging Cell2006，5，6：	1
19	Delayed and exaggerated postprandial complement component 3 response in familial combined hyperlipidemia 显示文摘	Meijssen S van Dijk H Verseyden C	2002	Arterioscler Thromb Vasc Biol2002，22，5：	1
20	Addition of glucose to an oral fat load reduces post-prandial free fatty acids and prevents the postprandial increase in complement component 3 显示文摘	VAN OOSTROM A J VAN DIJK H VERSEYDEN C	2004	Am J Clin Nutr2004，79，3：	1

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