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41篇 您的检索式:作者名="Verma CS"
    题名 作者 年代 出处 被引量
1T4 cervical esophageal cancer cured with modern chemoradiotherapy: A case report显示文摘BACKGROUND T4 esophageal cancer portends a poor prognosis,particularly when it is complicated by a tracheoesophageal fistula(TEF)either resulting from disease or occurring as a complication of treatment.Patients with TEF that occurs during treatment are commonly treated with palliative intent because fistula-associated treatment complications such as aspiration pneumonia and mediastinitis are associated with high morbidity and mortality.To date,there is no clear evidence on the optimal treatment of T4 esophageal cancer,particularly when a TEF formation occurs.CASE SUMMARY A 67-year-old gentleman who presented with dysphagia and weight loss.Endoscopy and imaging revealed a T4N1M0 cervical esophageal squamous cell carcinoma.He received image-guided intensity-modulated radiation therapy,with concurrent weekly carboplatin(area under curve 2 mg/mL per minute)and paclitaxel(50 mg/m2 of body surface area).One week after treatment initiation(16.2 Gy thus far),he developed cough on swallowing.A TEF was detected on image-guided radiation therapy using cone-beam computed tomography during the treatment course,for which a tracheal stent was inserted.After discussing the risks and morbidity of continuing treatment,he resumed chemoradiotherapy with an additional radiation dose of 45 Gy in 25 fractions.Three months after completion of chemoradiotherapy,he developed an esophageal stricture that required esophageal stenting and dilatation.The patient remains cancer-free at two year on follow-up.Complete response of esophageal cancer was evident on post-treatment endoscopy and computed tomography imaging,with successful closure of TEF.CONCLUSION This case highlights that successful curative treatment for esophageal cancer complicated by a TEF is possible using novel chemotherapeutic regimens and modern radiation technologies.Chia Ching Lee Chong Ming Yeo Wee Khoon Ng Akash Verma Jeremy CS Tey 2020World Journal of Clinical Cases2020,8,10:2
2RNA-mediated gene silencing: mechanisms and its therapeutic applications 显示文摘Verma NK Dey CS 2004J Clin Pharm Ther2004,29,5:1
3RNA-mediated gene silencing:mechanisms and its therapeutic applications显示文摘Verma NK Dey CS 2004J Clin Pharm Ther2004,29,5:1
4Modulation of p53 degra- dation as a therapeutic approach 显示文摘Dey A Verma CS Lane DP 2008Cancer2008,98,1:1
5Modulating the p53 pathway 显示文摘Dey A Lane DP Verma CS 2010Semin Cancer Biol2010,20,1:1
6RNA-mediated gene silencing:mechanisms and its therapeutic applications显示文摘Verma NK Dey CS 2004J Clin Pharm Ther2004,29,5:1
7Awakening guardian angels: drugging the p53 pathway显示文摘Brown C] Lain S Verma CS 2009Nat Rev Cancer2009,9,12:1
8Updates on p53: modulation ofp53 degradation as a therapeutic approach 显示文摘Dey A Verma CS Lane DP 2008Br J Cancer2008,98,1:1
9Awakening guardian angels:drugging the p53 pathway显示文摘Brown CJ1 Lain S Verma CS 2009Nat Rev Cancer2009,9,12:1
10Drugging the p53 pathway: under- standing the route to clinical efficacy显示文摘Khoo KH Verma CS Lane DP 2014Nat Rev Drug Discov2014,13,3:1
11Characterization of D1-pyrroline-5-carboxylate synthetase gene promoter in transgenic Arabidopsis thaliana subjected to water stress显示文摘Zhang CS Lu Q Verma DPS 1997Plant Sci1997,129,:1
12Awakening guardian angels :drugging the p53 pathway 显示文摘Brown CJ Lain S Verma CS 2009Nat Rev Cancer2009,9,12:1
13Drugging the p53 pathway: un- derstanding the route to clinical efficacy 显示文摘Khoo KH Verma CS Lane DP 2014Nat Rev Drug Dis- coy2014,13,3:1
14RNA-mediated gene silencing:mechanisms and its therapeutic applications显示文摘Verma NK Dey CS 2004J Clin Pharm Ther2004,29,5:1
15Ablation for longstanding permanent atrial fibrillation:results from a randomized study comparing three different strategies显示文摘Elayi CS Verma A Di Biase L 2008Heart Rhythm2008,5,:1
16Ablation for longstanding permanent atrial fibrillation: results from a randomized study compa- ring three different strategies显示文摘Elayi CS Verma A Di Blase L 2008Heart Rhythm2008,5,:1
17In vitro and in vivo antioxidant properties of different fractions of Moringa oleifera leaves显示文摘Verma AR Vijayakumar M Mathela CS 2009Food and Chemical Toxicology2009,47,9:1
18Updates on p53:modulation of p53 degradation as a therapertic approch显示文摘Dey A Verma CS Lane DP 2008Br J Cancer2008,98,1:1
19RNA-mediated gene silencing :mech- anisms and its therapeutic applications显示文摘Verma NK Dey CS 2004J Clin Pharm Ther2004,29,5:1
20Modulating the P53 pathway 显示文摘Dey A Lane DP Verma CS 2010Semin Cancer Biol2010,20,1:1
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