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| 1 | Ghrelin's second life:From appetite stimulator to glucose regulator显示文摘Ghrelin,a 28 amino acid peptide hormone produced by the stomach,was the first orexigenic hormone to be discovered from the periphery.The octanoyl modification at Ser3,mediated by ghrelin O-acyltransferase(GOAT),is essential for ghrelin's biological activity.Ghrelin stimulates food intake through binding to its receptor(GRLN-R) on neurons in the arcuate nucleus of the hypothalamus.Ghrelin is widely expressed throughout the body;accordingly,it is implicated in several other physiological functions,which include growth hormone release,gastric emptying,and body weight regulation.Ghrelin and GRLN-R expression are also found in the pancreas,suggesting a local physiological role.Accordingly,several recent studies now point towards an important role for ghrelin and its receptor in the regulation of blood glucose homeostasis,which is the main focus of this review.Several mechanisms of this regulation by ghrelin have been proposed,and one possibility is through the regulation of insulin secretion.Despite some controversy,most studies suggest that ghrelin exerts an inhibitory effect on insulin secretion,resulting in increased circulating glucose levels.Ghrelin may thus be a diabetogenic factor.Obesity-related type2 diabetes has become an increasingly important health problem,almost reaching epidemic proportions in the world;therefore,antagonists of the ghrelin-GOAT signaling pathway,which will tackle both energy-and glucose homeostasis,may be considered as promising new therapies for this disease. | Pieter-Jan Verhulst Inge Depoortere | 2012 | World Journal of Gastroenterology2012，18，25： | 10 |
| 2 | Thermodynamic behavior of metal chlorides and sulfates under the conditions of incineration furnaces显示文摘 | Verhulst D Buekens A Spencer P J | 1995 | Environ Sci Technol1995，30，1： | 1 |
| 3 | An active renal crystal clearance mechanism in rat and man显示文摘 | VERVAET BA VERHULST A DAUWE SE | 2009 | Kidney Int2009，75，1： | 1 |
| 4 | Sleep duration and metabolic dysregulation in overweight children and adolescents显示文摘 | Verhulst SL Schrauwen N Haentjens D | 2008 | Arch Dis Child2008，93，： | 1 |
| 5 | Endoscopic surgery in gynecologic practice显示文摘 | Verhulst G Pevroey P | 1995 | Int JGvnecolObstet1995，49，2： | 1 |
| 6 | Analysis of the risk factors with regard to the occurrence of ectopic pregnancy after medically assisted procreation显示文摘 | Verhulst G Camus M Bollen N | 1993 | Hum Reprod1993，8，： | 1 |
| 7 | Soil water content,maize yield and its stability as affected by tillage and crop residue management in rainfed semi-arid highlands显示文摘 | Verhulst N Nelissen V Jespers N Haven H Sayre K D Raes D Deckers J Govaerts B | 2011 | false Plant and Soil2011，344，12： | 1 |
| 8 | A retro spective study of 91 injections of botulinum toxin into the up- per sphincter of the oesophagus显示文摘 | VERHULST J AME P GUATTERIE M | 2003 | Rev Laryngol Otol Rhinol (Bord)2003，124，5： | 1 |
| 9 | Ecological immunology: costly parasite defences and trade-offs in evolutionary ecology显示文摘 | Ben C. Sheldon Simon Verhulst | 1996 | Trends in Ecology & Evolution1996，，： | 1 |
| 10 | Architectures for product families 显示文摘 | Erens F Verhulst K | 1997 | Computers in Industry1997，33，2： | 1 |
| 11 | Major life events and changes in the behavioral functioning of children显示文摘 | Berden GF Althaus M Verhulst FC | 1990 | Child Psychol Psychiatry1990，31，6： | 1 |
| 12 | Sleep deprived and swea- ting it out:the effects of total sleep deprivation on skin con- ductance reactivity to psychosocial stress 显示文摘 | Liu JC Verhulst S Massar SA | 2015 | Sleep2015，38，1： | 1 |
| 13 | Antral glutathione concentration and glutathione-S-transferase activity in patients with and without helicobacter pylori显示文摘 | Verhulst M L van Oijen A H Roelofs H M | 2000 | Dig Dis Sci2000，45，3： | 1 |
| 14 | Development of amouse model for assessing fatigue during chemotherapy 显示文摘 | Ray MA Trammell RA Verhulst S | 2011 | Comp Med2011，61，2： | 1 |
| 15 | Architecture for Product Families显示文摘 | Verhulst K | 1997 | Computer in Industry1997，33，2： | 1 |
| 16 | Endoscopic surgery in gynecologic pra- ctice显示文摘 | Verhulst G Perroey P | 1995 | JGynecol Obtset1995，9，： | 1 |
| 17 | Prospective community study of family stress and anxiety in (pre)adolescents:The TRAILS study显示文摘 | van Oort F V Verhulst F C Ormel J | 2010 | Eur Child Adolesc Psychiatry2010，19，6： | 1 |
| 18 | Intra-uterine insemina- tion for unexplained subfertility显示文摘 | Verhulst SM Cohlen BJ Hughes E | 2006 | Cochrane Database Syst Rev2006，18，9： | 1 |
| 19 | 1996, Ecological immunology: costly parasite defences and trade-offs in evolutionary ecology显示文摘 | Sheldon BC Verhulst S | 1996 | Trends in Ecology & Evolution1996，11，8： | 1 |
| 20 | An active renal crystal clearance mechanism in rat and man显示文摘 | Vervaet BA Verhulst A Dauwe SE | 2009 | Kidney Int2009，75，： | 1 |
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