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| 1 | Oligodendroglioma: CD44 as a possible prognostic opportunity显示文摘CD44, in its standard form as well in its isoforms, is a cell surface adhesion glycoprotein which occurs in a widevariety of non-neoplastic and neoplastic ceils. CD44 has been considered to be implicated in tumoral growth andin metastatic potential. We studied the immunohistochemical expression of CD44 standard in 30 oligodendrogliomas(19 primary lesions and 11 recurrences) in order to verify its possible prognostic role. Twelve primary oligoden- | Buccoliero AM Caldarella A Arganini L Mennonna P Ammanati F Taddei A Taddei GL | 2003 | 中国神经肿瘤杂志2003，1，3： | 8 |
| 2 | Postpartum depression:A systematic review of the genetics involved显示文摘Postpartum depression is one of the most prevalent psychopathologies. Its prevalence is estimated to be between 10% and 15%. Despite its multifactorial etiology, it is known that genetics play an important role in the genesis of this disorder. This paper reviews epidemiological evidence supporting the role of genetics in postpartum depression(PPD). The main objectives of this review are to determine which genes and polymorphisms are associated with PPD and discuss how this association may occur. In addition, this paper explores whether these genes are somehow related to or even the same as those linked to Major Depression(MD). To identify gaps in the current knowledge that require investigation, a systematic review was conducted in the electronic databases Pub Med, LILACS and Sci ELO using the index terms 'postpartum depression' and 'genetics'. Literature searches for articles in peerreviewed journals were made until April 2014. PPD was indexed 56 times with genetics. The inclusion criteria were articles in Portuguese, Spanish or English that were available by institutional means or sent by authors upon request; this search resulted in 20 papers. Genes and polymorphisms traditionally related to MD, which are those involved in the serotonin, catecholamine, brain-derived neurotrophic factor and tryptophan metabolism, have been the most studied, and some have been related to PPD. The results are conflicting and some depend on epigenetics, which makes the data incipient. Further studies are required to determine the genes that are involved in PPD and establish the nature of the relationship between these genes and PPD. | Tiago Castro e Couto Mayra Yara Martins Brancaglion António Alvim-Soares Lafaiete Moreira Frederico Duarte Garcia Rodrigo Nicolato Humberto Corrêa Regina Amélia Lopes P Aguiar Henrique Vitor Leite | 2015 | World Journal of Psychiatry2015，5，1： | 5 |
| 3 | Outcomes of critically ill cancer patients with Acinetobacter baumannii infection显示文摘AIM: To describe the intensive care unit(ICU) outcomes of critically ill cancer patients with Acinetobacter baumannii(AB) infection.METHODS: This was an observational study that included 23 consecutive cancer patients who acquired AB infections during their stay at ICU of the National Cancer Institute of Mexico(INCan), located in Mexico City. Data collection took place between January 2011, and December 2012. Patients who had AB infections before ICU admission, and infections that occurred during the first 2 d of ICU stay were excluded. Data were obtained by reviewing the electronic health record of each patient. This investigation was approved by the Scientific and Ethics Committees at INCan. Because of its observational nature, informed consent of the patients was not required.RESULTS: Throughout the study period, a total of 494 critically ill patients with cancer were admitted to the ICU of the INCan, 23(4.6%) of whom developed AB infections. Sixteen(60.9%) of these patients had hematologic malignancies. Most frequent reasons for ICU admission were severe sepsis or septic shock(56.2%) and postoperative care(21.7%). The respiratory tract was the most frequent site of AB infection(91.3%). The most common organ dysfunction observed in our group of patients were the respiratory(100%), cardiovascular(100%), hepatic(73.9%) and renal dysfunction(65.2%). The ICU mortality of patients with 3 or less organ system dysfunctions was 11.7%(2/17) compared with 66.6%(4/6) for the group of patients with 4 or more organ system dysfunctions(P = 0.021). Multivariate analysis identified blood lactate levels(BLL) as the only variable independently associated with inICU death(OR = 2.59, 95%CI: 1.04-6.43, P = 0.040). ICU and hospital mortality rates were 26.1% and 43.5%, respectively.CONCLUSION: The mortality rate in critically ill patients with both HM, and AB infections who are admitted to the ICU is high. The variable most associated with increased mortality was a BLL ≥ 2.6 mmol/L in the first day of stay in the ICU. | Silvio A ?amendys-Silva Paulina Correa-García Francisco J García-Guillén María O González-Herrera Américo Pérez-Alonso Julia Texcocano-Becerra Angel Herrera-Gómez Patricia Cornejo-Juárez Abelardo Meneses-García | 2015 | World Journal of Critical Care Medicine2015，4，3： | 3 |
| 4 | Saccharomyces cerevisiae CNCM I-3856 in irritable bowel syndrome: An individual subject meta-analysis显示文摘AIM To confirm previous conclusions on Saccharomyces cerevisiae(S. cerevisiae) CNCM I-3856 for irritable bowel syndrome(IBS) management.METHODS An individual patient data meta-analysis was performed on two randomized clinical trials studying the effect of S. cerevisiae CNCM I-3856 supplementation on gastrointestinal(GI) symptoms in IBS subjects. A total of 579 IBS subjects were included. Outcomes were the daily Likert scale scores of abdominal pain/discomfort and bloating [area under the curve(AUC) and weekly means], responder status, and bowel movements(stool frequency and consistency). Statistical analyses were conducted in Intent to Treat(ITT) population, IBS-C subjects and IBS-C subjects with an abdominal pain/discomfort score higher than or equal to 2 at baseline('IBS-C ≥ 2 subpopulation').RESULTS S. cerevisiae CNCM I-3856 significantly improved abdominal pain/discomfort and bloating during the second month of supplementation [AUC(W5-W8)]with improvement up to the minimal clinically relevant threshold of 10%: a 12.3% reduction of abdominal pain/discomfort in the ITT population compared to the Placebo group(P = 0.0134) has been observed. In the IBS-C ≥ 2 subpopulation, there were a 13.1% reduction of abdominal pain/discomfort and a 14.9% reduction of bloating compared to the Placebo group(P = 0.0194 and P = 0.0145, respectively). GI symptoms significantly decreased during supplementation but no statistical differences were reported between groups at the end of the supplementation period. Responder status was defined as a subject who experienced a decrease of 1 arbitrary unit(a.u.) or 50% of the abdominal discomfort score from baseline for at least 2 wk out of the last 4 wk of the study. A significant difference between groups was reported in the ITT population, when considering the first definition: subjects in the Active group had 1.510 higher odds to be a responder(reduction of 1 a.u. of abdominal pain/discomfort) compared with subjects in the Placebo group(P = 0.0240). At the end of supplementation period, stool consistency in the Active group of the ITT population was significantly improved and classified as 'normal' compared to Placebo(respectively 3.13 ± 1.197 a.u. vs 2.58 ± 1.020 a.u., P = 0.0003). Similar results were seen in the IBS-C ≥ 2 subpopulation(Active group: 3.14 ± 1.219 a.u. vs Placebo group: 2.59 ± 1.017 a.u., P = 0.0009).CONCLUSION This meta-analysis supports previous data linking S. cerevisiae I-3856 and improvement of GI symptoms, in IBS overall population and in the IBS-C and IBS-C ≥ 2 subpopulations. | Amélie Cayzeele-Decherf Fanny Pélerin Sébastien Leuillet Benoit Douillard Béatrice Housez Murielle Cazaubiel Gunnard K Jacobson Peter Jüsten Pierre Desreumaux | 2017 | World Journal of Gastroenterology2017，23，2： | 2 |
| 5 | 高密度脂蛋白可追踪脑卒中恢复情况显示文摘前瞻性队列研究质疑高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)在脑卒中风险预测中的价值。该文旨在探讨长期功能恢复与高密度脂蛋白(high density lipoprotein,HDL)蛋白质组和功能的关系。方法与结果:测定急性缺血性脑卒中后2个时间点(24小时,35例;96小时,20例)和35例对照组HDL蛋白组成和功能(胆固醇流出能力)的变化。 | Plubell DL Fenton AM Rosario S Bergstrom P Wilmarth PA Clark WM Zakai NA Quinn JF Minnier J Alkayed NJ Fazio S Pamir N 刘青(译) 刘莉(摘/审校) | 2020 | 中华高血压杂志2020，28，11： | 2 |
| 6 | Role of urokinase in the superior mesenteric artery embolism显示文摘 | Gallego AM Ramirez P Rodriguez JM | 1996 | Surgery1996，120，1： | 2 |
| 7 | Pain produced by electric stimulation of the rectum in patients with irritable bowel syndrome:further evidence of visceral hyperalgesia显示文摘 | Rossel P Drewes AM Petersen P | 1999 | Scand J Gastroenterol1999，34，10： | 2 |
| 8 | Toxicity of non-A beta component of Alzheimer's disease amyloid, and N-terminal fragments thereof, correlates to formation of β-sheet structure and fibrils显示文摘 | Bodles AM Guthrie DJ Harriott P | 2000 | Eur J Biochem2000，267，： | 1 |
| 9 | A controlled trial of psycho -educational interventions in preparing Chinese women for elective hysterectomy显示文摘 | Cheung LH Callaghan P Chang AM | 2003 | International Journal of Nursing Studies2003，40，2： | 1 |
| 10 | The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) : a review of its utility and measurement properties显示文摘 | McConnell S Kolopack P Davis AM | 2001 | Arthritis Care Res2001，45，： | 1 |
| 11 | Executive functioning in unipolardep ression:a review显示文摘 | Fossati P Ergis AM Allilaire JF | 2002 | Encephale2002，28，2： | 1 |
| 12 | Comparable 3-year outcome following ABVD or BEACOPP first-line chemotherapy,plus preplanned high-dose salvage,in advanced Hodgkin lymphoma(HL):a randomized trial of the Michelangelo,GITIL and IIL cooperatives显示文摘 | Gianni AM Rambaldi A Zinzani P | 2008 | J Clin Oncol(ASCO Annual Meeting Abstracts)2008，，： | 1 |
| 13 | The evolutionary history of chromosomal super integrons provides an ancestry for multiresistant integrons显示文摘 | Rowe-Magnus DA Guerout AM Ploncard P | 2001 | Pro Natl AcaSci USA2001，98，2： | 1 |
| 14 | Automated high-performance liquid chromatography method for the determination of rosiglitazone in human plasma显示文摘 | Muxlow AM Fowles S Russell P | 2001 | J Chrornatogr B2001，752，1： | 1 |
| 15 | Preparation and characterization of the recombinant selenomethionine analogue of insulin-like growth factor-Ⅰ 显示文摘 | De Bree FM Brzozowski AM Gellerfors P | 1998 | Protein Expr Purif1998，13，3： | 1 |
| 16 | Artificial neural network model of the mapping between electromyographic activation and trajectory patterns in free-arm movements 显示文摘 | Dipietro L Sabatini AM Dario P | 2003 | Med Biol Eng Comput2003，41，2： | 1 |
| 17 | Clinical evaluation of the Gen-probe amplified direct test for detection of mycobacterium tuberculosis complex organisms in cerebrospinal fluid 显示文摘 | Lang AM Foils IJ Chabela P | 1998 | Clin Microbiol1998，36，8： | 1 |
| 18 | Improvement of quantitative angiography by exact calculation of radiological magnification factors显示文摘 | Wollschlager H Lee P Zeiher AM | 1985 | Journal of Computers in Cardiology1985，93，103： | 1 |
| 19 | Biology of ischemic cerebral cell death 显示文摘 | Small DL Morley P Buchan AM | 1999 | Prog Cardiovasc Dis1999，42，3： | 1 |
| 20 | Transforming growth factor-beta expression in mueosal biopsies in asthma and chronic bronchitis显示文摘 | Vignola AM Chanez P Chiappara G | 1997 | AM J Respir Cru Care Med1997，156，21： | 1 |
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