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| 1 | Increased duodenal expression of mi R-146a and-155 in pediatric Crohn's disease显示文摘AIM: To evaluate the role of micro RNA(mi R)-146 a,-155 and-122 in the duodenal mucosa of pediatric patients with Crohn's disease(CD) and the effect of transforming growth factor-β(TGF-β) on these mi Rs in duodenal epithelial and fibroblast cells.METHODS: Formalin-fixed, paraffin-embedded biopsies derived from the macroscopically inflamed(CD inflamed: n = 10) and intact(CD intact: n = 10) duodenal mucosa of pediatric CD patients and control children(C: n = 10) were examined. Expression of mi R-146 a,-155 and-122 was determined by realtime polymerase-chain reaction(PCR). The expression of the above mi Rs was investigated in recombinant human TGF-β(1 nmol/L, 24 h) or vehicle treated small intestinal epithelial cells(CCL-241) and primary duodenal fibroblast cells derived from healthy children as well.RESULTS: Expression of mi R-146 a was significantly higher in the inflamed duodenal mucosa compared to the intact duodenal mucosa of children with CD(CD inflamed: 3.21 ± 0.50 vs CD intact: 0.62 ± 0.26, p ≤ 0.01) and to the control group(CD inflamed: 3.21 ± 0.50 vs C: 1.00 ± 0.33, p ≤ 0.05). The expression of mi R-155 was significantly increased in the inflamed region of the duodenum compared to the control group(CD inflamed: 4.87 ± 1.02 vs Control: 1.00 ± 0.40, p ≤ 0.001). The expression of mi R-122 was unchanged in the inflamed or intact mucosa of CD patients compared to controls. TGF-β treatment significantly decreased the expression of mi R-155 in small intestinal epithelial cells(TGF-β: 0.7 ± 0.083 vs Control: 1 ± 0.09, p ≤ 0.05) and also the expression of mi R-146a(TGF-β: 0.67 ± 0.04 vs Control: 1 ± 0.15, p ≤ 0.01) and mi R-155(TGF-β: 0.72 ± 0.09 vs Control: 1 ± 0.06, p ≤ 0.05) in primary duodenal fibroblasts compared to corresponding vehicle treated controls. TGF-β treatment did not influence the expression of mi R-122.CONCLUSION: The elevated expression of mi R-146 a and-155 in the inflamed duodenal mucosa of CD patients suggests the role of these mi Rs in the pathomechanism of inflammatory bowel disease. Antiinflammatory TGF-β plays an important role in the regulation of the expression of these mi Rs. | Dániel Szucs Nóra Judit Béres Réka Rokonay Kriszta Boros Katalin Borka Zoltán Kiss András Arató Attila J Szabó ádám Vannay Erna Sziksz Csaba Bereczki Gábor Veres | 2016 | World Journal of Gastroenterology2016，22，26： | 2 |
| 2 | The veres adapter: clinical experience with a new device for jet bronchoscopy ventilation via a laryngeal mask airway during flexible显示文摘 | Veres J Slavei K Errhalt P | 2011 | Anesth Analg2011，112，3： | 1 |
| 3 | Manganese based spinel-like ceramics withNTC-type thermistor behaviour显示文摘 | VERES A NOUDEM J G PEREZ O | 2007 | Solid State Ionics2007，178，56： | 1 |
| 4 | Structure identification for bounded-parameter models: consistency conditions and selection criterion显示文摘 | Veres S M Norton J P | 1991 | IEEE Trans Aurora Control1991，36，4： | 1 |
| 5 | Synthesis of biocompatible nanocomposite hydrogels as alocal drug delivery system显示文摘 | Bako J Szepesi M Veres A J | | 0，，03： | 1 |
| 6 | Modified minimally invasive surgi- cal approach to cervical neuromas with intraforaminal components: hemi - semi - laminectomy and supraforaminal burr hole ( modified foraminotomy) technique 显示文摘 | Banczerowski P Veres R Vajda J | 2009 | Minim Invasive Neurosnrg2009，52，： | 1 |
| 7 | Vapor-phase synthesis of titanium nitride显示文摘 | Dekker J P Vanderput P J Vering H J | 1994 | J Mater Chem1994，4，： | 1 |
| 8 | Bioavailability of levodopa after consumption of Viciafaba seedlings by Parkinsonian patients and control subjects显示文摘 | Vered Y Rabey J M Paleveitch D | 1994 | Clinical Neuropharmacology1994，17，2： | 1 |
| 9 | Absence of tachycardia during tilt test predicts failure of β-blocker therapy in patients with neurocardiogenic syncope 显示文摘 | Leor J Rotstein Z Vered Z | 1994 | Am Heart J1994，127，： | 1 |
| 10 | Tooth - supported, magnet - retained overdentures : a review显示文摘 | Vere J Deans RF | 2009 | Dent Update2009，36，5： | 1 |
| 11 | An evaluation of the surface characteristics of a facial prosthetic elastoomer显示文摘 | Veres E M Wolfaardt J F Becker P J | 1990 | Prosthet Dent1990，63，3： | 1 |
| 12 | VOC identification and inter-comparison from laboratory biomass burning using PTR-MS and PIT-MS显示文摘 | Warneke C Roberts J M Veres P et a1 | 2011 | International Journal of Mass Spectrometry2011，303，1： | 1 |
| 13 | 查看详情显示文摘 | Veres J Ogier S Lloyd G de Leeuw D | | 0，，： | 1 |
| 14 | High-fidelity three-di- mensional simulation of the GE90显示文摘 | Turner M G Norris A Veres J P | 2003 | AIAA 2003-39962003，，： | 1 |
| 15 | Impressions in im-plant dentistry 显示文摘 | BHAKTA S VERE J CALDER I | 2011 | British dental journal2011，211，8： | 1 |
| 16 | Intracellular expression of RNA transcripts complementary to the human immunodficiency virus type 1 gag gene inhibits viral replication in human CD4+ lymphocytes显示文摘 | S Escaich J Baker | 1996 | J Virol1996，70，12： | 1 |
| 17 | Frequency selective feedback for active noise control显示文摘 | Meurers T Veres S M Elliott S J | 2002 | IEEE Control Systems Magazine2002，22，4： | 1 |
| 18 | Bio-inspired backlashreduction of a low-cost robotic joint using closed-loopcommutatedstepper motors 显示文摘 | Veres J Cserey G Szederkenyi G | 2013 | Robotica2013，31，5： | 1 |
| 19 | Synthesis of biocompatible nanocomposite hydrogels as a local drug delivery system 显示文摘 | Bako J Szepesi M Veres A J | 2008 | Colloid Polym Sci2008，286，3： | 1 |
| 20 | The Veres adapter:clinical experience with a new device for jet ventilation via a laryngeal mask airway during flexible显示文摘 | Veres J Slavei K Errhalt P et a1 | 2011 | Anesth Analg2011，112，3： | 1 |
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