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| 1 | Splanchnic vasodilation and hyperdynamic circulatory syndrome in cirrhosis显示文摘Portal hypertension is a clinical syndrome which leads to several clinical complications,such as the formation and rupture of esophageal and/or gastric varices,ascites,hepatic encephalopathy and hepato-renal syndrome.In cirrhosis,the primary cause of the increase in portal pressure is the enhanced resistance to portal outflow.However,also an increase in splanchnic blood flow worsens and maintains portal hypertension.The vasodilatation of arterial splanchnic vessels and the opening of collateral circulation are the determinants of the increased splanchnic blood flow.Several vasoactive systems/substances,such as nitric oxide,cyclooxygenase-derivatives,carbon monoxide and endogenous cannabinoids are activated in portal hypertension and are responsible for the marked splanchnic vasodilatation.Moreover,an impaired reactivity to vasoconstrictor systems,such as the sympathetic nervous system,vasopressin,angiotensinⅡand endothelin-1,plays a role in this process.The opening of collateral circulation occurs through the reperfusion and dilatation of preexisting vessels,but also through the generation of new vessels.Splanchnic vasodilatation leads to the onset of the hyperdynamic circulatory syndrome,a syndrome which occurs in pa-tients with portal hypertension and is characterized by increased cardiac output and heart rate,and decreased systemic vascular resistance with low arterial blood pressure.Understanding the pathophysiology of splanchnic vasodilatation and hyperdynamic circulatory syndrome is mandatory for the prevention and treatment of portal hypertension and its severe complications. | Massimo Bolognesi Marco Di Pascoli Alberto Verardo Angelo Gatta | 2014 | World Journal of Gastroenterology2014，20，10： | 21 |
| 2 | Peculiar characteristics of portal-hepatic hemodynamics of alcoholic cirrhosis显示文摘Alcohol-related cirrhosis is a consequence of heavy and prolonged drinking. Similarly to patients with cirrhosis of other etiologies, patients with alcoholic cirrhosis develop portal hypertension and the hepatic, splanchnic and systemic hemodynamic alterations that follow. However, in alcoholic cirrhosis, some specific features can be observed. Compared to viral cirrhosis, in alcohol-related cirrhosis sinusoidal pressure is generally higher, hepatic venous pressure gradient reflects portal pressure better, the portal flow perfusing the liver is reduced despite an increase in liver weight, the prevalence of reversal portal blood flow is higher, a patent paraumbilical vein is a more common finding and signs of hyperdynamic circulations, such as an increased cardiac output and decreased systemic vascular resistance, are more pronounced. Moreover, alcohol consumption can acutely increase portal pressure and portal-collateral blood flow. Alcoholic cardiomyopathy, another pathological consequence of prolonged alcohol misuse, may contribute to the hemodynamic changes occurring in alcohol-related cirrhosis. The aim of this review was to assess the portal-hepatic changes thatoccur in alcohol-related cirrhosis, focusing on the differences observed in comparison with patients with viral cirrhosis. The knowledge of the specific characteristics of this pathological condition can be helpful in the management of portal hypertension and its complications in patients with alcohol-related cirrhosis. | Massimo Bolognesi Alberto Verardo Marco Di Pascoli | 2014 | World Journal of Gastroenterology2014，20，25： | 5 |
| 3 | Fernán dezGuti érrez A显示文摘 | Gómez-Caravaca A M Verardo V Segura-Carretero A | 2008 | J Chromatogr A2008，，： | 1 |
| 4 | DLX5 overexpression impairs osteogenic differentiation of human bone marrow stromal cells显示文摘 | Muraglia A PereraM Verardo S etal | 2008 | Eur J Cell Biol2008，87，10： | 1 |
| 5 | Late Pleistocene charcoal in tropical Atlantic deep-sea sediments:climate and geochemical significance显示文摘 | Verardo D J Rudiman W F | 1996 | Geology1996，24，9： | 1 |
| 6 | Gas6 anti-apoptotic signaling requires NF-kappa B activation显示文摘 | Demarchi F Verardo R Varnum B et at | | 0，，34： | 1 |
| 7 | Defective neuronogenesis in the absence of Dlx5显示文摘 | Perera M Merlo GR Verardo S | 2004 | Mol Cell Neurosci2004，25，1： | 1 |
| 8 | Evaluation of lipid oxidation in spaghetti pasta enriched with long chain n ?3 polyunsaturated fatty acids under different storage conditions显示文摘 | Vito Verardo Federico Ferioli Ylenia Riciputi Giovanna Iafelice Emanuele Marconi Maria Fiorenza Caboni | 2008 | Food Chemistry2008，，： | 1 |
| 9 | Antioxidant Phenols in Barley ( Hordeum vulgare L ) Flour: Comparative Spectrophotometric Study among Extraction Methods of Free and Bound Phenolic Compounds 显示文摘 | Bonoli M Verardo V Marconi E | 2004 | J Agric Food Chem2004，52，： | 1 |
| 10 | Hypoalbuminemia 显示文摘 | Gatta A Verardo A Bolognesi M | 2012 | Intern Emerg Med2012，7，3： | 1 |
| 11 | Abnormal reactivity of muller cells after retinal detachment in mice deficient in GFAP and vimentin显示文摘 | Verardo MR Lewis GP Takeda M | | 0，，： | 1 |
| 12 | A thorough study of the surface wax of apple fruits显示文摘 | Giancarlo Verardo Emanuela Pagani Paola Geatti | 2003 | Ana- lytical and Bioanalytical Chemistry2003，376，5： | 1 |
| 13 | Identification of buckwheat phenolic compounds by reverse phase high performance liquid chromatography - electrospray ioniza- tion - time of flight - mass spectrometry ( RP - HPLC - ESI - TOF - MS) 显示文摘 | VERARDO V ARRAEZ - ROMAN D SEGURA - CARRETERO A | 2010 | Cereal Sci2010，52，2： | 1 |
| 14 | Influence of storage condi- tions on cholesterol oxidation in dried egg pasta 显示文摘 | Verardo V Pasini F Iafelice G | 2010 | Agric Food Chem2010，，： | 1 |
| 15 | Institutional Trade Persistence and Long Term Equity Returns显示文摘 | Dasgupta A Prat A Verardo M | 2011 | The ioumal of finance2011，66，2： | 1 |
| 16 | DLX5 overexpression impairs osteogenic differentiation of human bone marrow stromal cells显示文摘 | Muraglia A Perera M Verardo S | 2008 | Eur J Cell Biol2008，87，10： | 1 |
| 17 | Role of cereal type and processing in whole grain in vivo protection from oxidative stress显示文摘 | Gianotti A Danesi F Verardo V | | 0，，： | 1 |
| 18 | Defective neuronogenesis in the absence of Dlx5 显示文摘 | Perera M Merlo G R Verardo S | 2004 | Mol Cell Neruosci2004，25，1： | 1 |
| 19 | Rapid detection of high- molecular-mass dienes in beeswax 显示文摘 | Giumanini AG Verardo G Strazzolini P | 1995 | J Chromatogr A1995，1118，1： | 1 |
| 20 | Identification of buckwheat phenolic com- pounds by reverse phase high performance liquid chroma- tography-electrospray ionization-time of flight-mass spec- trometry (RP-HPLC-ESI-TOF-MS) 显示文摘 | Vito Verardo David Arraez-Roman Antonio Segura-Car- retero | 2010 | Journal of Cereal Science2010，52，2： | 1 |
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