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| 1 | Gallstone ileus:One-stage surgery in a patient with intermittent obstruction显示文摘Gallstone ileus, an uncommon complication of cholelithiasis, is described as a mechanical intestinal obstruction due to impaction of one or more large gallstones within the gastrointestinal tract. The clinical presentation is variable, depending on the site of obstruction, manifested as acute, intermittent or chronic episodes. A 51-year-old female patient was referred to our hospital with 3 events of intestinal obstruction during the previous 7 d. At admission, there were clinical signs of intestinal obstruction; abdominal film demonstrated dilated bowel loops, air-fluid levels and a vague image of a stone in the inferior left quadrant. Once stabilized, a laparotomy was performed. Surgical findings were distention of the jejunum and ileum proximal to a palpable stone in the ileum as well as gallstones and a cholecystoduodenal fistula in the gallbladder. An enterolithotomy, repair of the cholecystoduodenal fistula and cholecystectomy were performed. The postoperative course was uneventful. There is no uniform surgical procedure for this disease. When the patient is too ill or when biliary surgery is not advisable, an enterolithotomy is the best option. The one-stage procedure should be the offered to adequately stabilized patients when local and general conditions, such as good cardiorespiratory and metabolic reserve permit a more prolonged surgical procedure. | Carlos M Nuo-Guzmán José Arróniz-Jáuregui Pável A Moreno-Pérez édgar A Chávez-Solís Nereida Esparza-Arias Cuauhtémoc I Hernández-González | 2010 | World Journal of Gastrointestinal Surgery2010，2，5： | 5 |
| 2 | Cognitive disorder and dementia in type 2 diabetes mellitus显示文摘Insulin,a key pleiotropic hormone,regulates metabolism through several signaling pathways in target tissues including skeletal muscle,liver,and brain.In the brain,insulin modulates learning and memory,and impaired insulin signaling is associated with metabolic dysregulation and neurodegenerative diseases.At the receptor level,in aging and Alzheimer’s disease(AD)models,the amount of insulin receptors and their functions are decreased.Clinical and animal model studies suggest that memory improvements are due to changes in insulin levels.Furthermore,diabetes mellitus(DM)and insulin resistance are associated with age-related cognitive decline,increased levels ofβ-amyloid peptide,phosphorylation of tau protein;oxidative stress,pro-inflammatory cytokine production and dyslipidemia. Recent evidence shows that deleting brain insulin receptors leads to mildobesity and insulin resistance without influencing brain size and apoptosis development.Conversely, deleting insulin-like growth factor 1 receptor (IGF-1R) affects brain size anddevelopment, and contributes to behavior changes. Insulin is synthesized locally in the brain andis released from the neurons. Here, we reviewed proposed pathophysiological hypotheses toexplain increased risk of dementia in the presence of DM. Regardless of the exact sequence ofevents leading to neurodegeneration, there is strong evidence that mitochondrial dysfunctionplays a key role in AD and DM. A triple transgenic mouse model of AD showed mitochondrialdysfunction, oxidative stress, and loss of synaptic integrity. These alterations are comparable tothose induced in wild-type mice treated with sucrose, which is consistent with the proposal thatmitochondrial alterations are associated with DM and contribute to AD development. Alterationsin insulin/IGF-1 signaling in DM could lead to mitochondrial dysfunction and low antioxidantcapacity of the cell. Thus, insulin/IGF-1 signaling is important for increased neural processing andsystemic metabolism, and could be a specific target for therapeutic strategies to decreasealterations associated with age-related cognitive decline. | Genaro G Ortiz Miguel Huerta Héctor A González-Usigli Erandis D Torres-Sánchez Daniela LC Delgado-Lara Fermín P Pacheco-Moisés Mario A Mireles-Ramírez Blanca MG Torres-Mendoza Roxana I Moreno-Cih Irma E Velázquez-Brizuela | 2022 | World Journal of Diabetes2022，13，4： | 2 |
| 3 | Modifi cation of sleep architecture in an animal model of experimental cirrhosis显示文摘AIM: To analyze the polygraphic sleep patterns during cirrhosis progression in a rat model by repeated CCl4 administration. METHODS: Male Wistar rats received three weekly injections of CCl4 for 11 wk, and were analyzed before and during the induction of cirrhosis. Rats were implanted with electrodes to record their sleep patterns. Polygraph recordings were made weekly over 11 wk for 8 h, during the light period. After a basal recording, rats received three weekly injections of CCl4. Histological conf irmation of cirrhosis was performed after 11 wk.RESULTS: The results showed a progressive decrease in total wake time that reached statistical signif icance from the second week of treatment. In addition, there was an increase in total time of slow wave sleep (SWS) and rapid eye movement sleep (REM sleep) in most of the 11 wk. SWS showed no signif icant variations.During the final weeks, a significant increase in REM sleep frequency was also observed. Histological analyses of the livers showed unequivocal signs of cirrhosis. CONCLUSION: These data suggest that hepatic failure produced by CCl4 administration is capable of modifying the sleep pattern even after only a few doses. | Anabel Jiménez-Anguiano Vanessa Díaz-Medina Blanca Eugenia Farfán-Labonne Gloria Giono-Chiang David Kersenobich Mario García-Lorenzana Maria Concepción Gutiérrez-Ruiz Javier Velázquez-Moctezuma | 2009 | World Journal of Gastroenterology2009，15，41： | 2 |
| 4 | Business Model Innovation through Trial- and- Error Learning: The Naturhouse Case 显示文摘 | SOSNA M TREVINYORODNGUEZ R N VEL AMURI S R | 2010 | Long Range Planning2010，43，23： | 1 |
| 5 | Ozone and hydroxyl radicals induced oxidation of glycine显示文摘 | Berger P Karpel Vel Leitner N Doré M | 1999 | Wat Res1999，33，2： | 1 |
| 6 | The selection and properties of Penicillium verruculosum mutants with enhanced production of cellulases and xylanases 显示文摘 | Soloveva I V Okunev O N Vel'kov V V | 2005 | Microbiology2005，74，2： | 1 |
| 7 | Nature or nurture:let food be your epigenetic medicine in chronic inflammatory disorders 显示文摘 | SZARC VEL SZIC K NDLOVU M N HAEGEMAN G | 2010 | Bio- chemical Pharmacology2010，80，12： | 1 |
| 8 | Catalytic ozonation: a promising advanced oxidation technology for water treatment 显示文摘 | Legube B Karpel Vel Leitner N | 1999 | Catal Today1999，53，1： | 1 |
| 9 | Similarity of the Cinl repetitive family of Zea mays to eukaryotic transposable elements显示文摘 | Shepherd N S Schwarz-Sommer Z Blumberg vel Spalve J et a1 | 1984 | Nature1984，307，5947： | 1 |
| 10 | Catalytic ozonation:a promising advanced oxidation technology for water treatment显示文摘 | Legube B Karpel Vel Leitner N | 1999 | Catal Today1999，53，1： | 1 |
| 11 | Impact of catalytic ozonation on the removal of a chelating agent and surfactants in aqueous solution显示文摘 | Karpel Vel Leitner N Gombert B Legube B | 1998 | Water Sci Technol1998，38，45： | 1 |
| 12 | A theoretical basis for the use of principal components models for monitoring multivariate processes 显示文摘 | Wise B M Ricker N L Vel Tkamp D J | 1990 | Process Control and Quality1990，1，1： | 1 |
| 13 | HP0953-hypothetical virulence factor overexpresion and localization during Helicobacter pylori infection of gastric epithelium显示文摘BACKGROUND The high prevalence and persistence of Helicobacter pylori(H. pylori) infection, as well as the diversity of pathologies related to it, suggest that the virulence factors used by this microorganism are varied. Moreover, as its proteome contains 340hypothetical proteins, it is important to investigate them to completely understand the mechanisms of its virulence and survival. We have previously reported that the hypothetical protein HP0953 is overexpressed during the first hours of adhesion to inert surfaces, under stress conditions, suggesting its role in the environmental survival of this bacterium and perhaps as a virulence factor.AIM To investigate the expression and localization of HP0953 during adhesion to an inert surface and against gastric(AGS) cells.METHODS Expression analysis was performed for HP0953 during H. pylori adhesion. HP0953 expression at 0,3, 12, 24, and 48 h was evaluated and compared using the Kruskal-Wallis equality-of-populations rank test. Recombinant protein was produced and used to obtain polyclonal antibodies for immunolocalization. Immunogold technique was performed on bacterial sections during adherence to inert surfaces and AGS cells, which was analyzed by transmission electron microscopy. HP0953 protein sequence was analyzed to predict the presence of a signal peptide and transmembrane helices, both provided by the ExPASy platform, and using the GLYCOPP platform for glycosylation sites. Different programs, via, I-TASSER, RaptorX, and HHalign-Kbest, were used to perform three-dimensional modeling.RESULTS HP0953 exhibited its maximum expression at 12 h of infection in gastric epithelium cells.Immunogold technique revealed HP0953 localization in the cytoplasm and accumulation in some peripheral areas of the bacterial body, with greater expression when it is close to AGS cells.Bioinformatics analysis revealed the presence of a signal peptide that interacts with the transmembrane region and then allows the release of the protein to the external environment. The programs also showed a similarity with the Tip-alpha protein of H. pylori. Tip-alpha is an exotoxin that penetrates cells and induces tumor necrosis factor alpha production, and HP0953 could have a similar function as posttranslational modification sites were found;modifications in turn require enzymes located in eukaryotic cells. Thus, to be functional, HP0953 may necessarily need to be translocated inside the cell where it can trigger different mechanisms producing cellular damage.CONCLUSION The location of HP0953 around infected cells, the probable posttranslational modifications, and its similarity to an exotoxin suggest that this protein is a virulence factor. | Nancy K Arteaga-Resendiz Gerardo E Rodea Rosa María Ribas-Aparicio Alma L Olivares-Cervantes Juan Arturo Castelán-Vega Joséde Jesús Olivares-Trejo Sandra Mendoza-Elizalde Edgar O López-Villegas Christian Colín Pamela Aguilar-Rodea Alfonso Reyes-López Marcela Salazar García Norma Velázquez-Guadarrama | 2022 | World Journal of Gastroenterology2022，28，29： | 1 |
| 14 | The Selection and Properties of Penicillium verruculosum Mutants with Enhanced Produetion of Cellulases and Xylanases 显示文摘 | I V Soloeva O N Okunev V V Vel' kov | 2005 | Microbiology2005，74，： | 1 |
| 15 | Ozone and hydroxyl radicals induced oxidation of glycine显示文摘 | Berger P Karpel Vel Leitner N Dore M | 1999 | Wat Res1999，，33： | 1 |
| 16 | Generation of active entities by the pulsed arc electrohydraulic discharge system and application to removal of atrazine显示文摘 | Karpel Vel Leitner N Syoen G Romat H | 2005 | Water Research2005，39，： | 1 |
| 17 | Catalytic ozonation :a promising advanced oxidation technology for water treatment 显示文摘 | Legube B Leitner K Vel N | 1999 | Catalysis Today1999，53，3： | 1 |
| 18 | , Caflystic ozonation:a promising advnaced oxidation technology of water treatment 显示文摘 | Legube B Karpel Vel Leiter N | 1999 | Catalysis today1999，，53： | 1 |
| 19 | Catalytic ozonation:a promising advanced oxidation technology for water treatment显示文摘 | LEGUBE B LEITNER K VEL N | 1999 | Catalysis Today1999，53，3： | 1 |
| 20 | Generation of active entities by the pulsed arc electrohydraulic discharge system and application to removal of atrazine显示文摘 | Karpel Vel Leitner N Syoen G Romat H | 2005 | Water Research2005，39，： | 1 |
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