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| 1 | 肝硬化与睡眠障碍显示文摘肝硬化患者常表现出睡眠障碍,最新研究显示睡眠障碍或许与肝硬化患者不良预后有关。本文讨论睡眠障碍与肝性脑病(HE)和肝肺综合征(HPS)等肝硬化并发症之间的关系,并对其在原发性胆汗性肝硬化、丙型肝炎、非酒精性脂肪肝、wilson病等几种特殊病因引起的肝硬化中的作用作一综述。 | 吴鉴今 姚定康 | 2013 | 临床肝胆病杂志2013，29，5： | 6 |
| 2 | Polysomnographic sleep aspects in liver cirrhosis: A case control study显示文摘AIM: To study sleep aspects and parameters in cirrhotic patients and assess the role of liver dysfunction severity in polysomnographic results. METHODS: This was a case-control study. Patients with a diagnosis of liver cirrhosis were consecutively enrolled in the study. Clinical examinations and laboratory liver tests were performed in all patients, and disease severity was assessed using the Child-Pugh score. The control group consisted of ageand gender-matched healthy volunteers. All individuals answered a questionnaire about habits, behaviors, and complaints related to sleep and were submitted to polysomnography. Sleep parameters were compared between the two groups, and separate analyses were performed among classesof Child-Pugh classification in the cirrhotic group. RESULTS: Forty-two cirrhotic patients and forty-two controls were enrolled. Compared to the control group, the cirrhotic group exhibited lower sleep efficiency (mean ± SD: 73.89% ± 14.99% vs 84.43% ± 8.55%, P < 0.01), increased latency (151.27 ± 93.24 min vs 90.62 ± 54.74 min, P < 0.01) and a lower percentage of rapid eye movement (REM) sleep (14.04% ± 5.64% vs 20.71% ± 6.77%, P < 0.05) as well as a higher frequency of periodic limb movements (10.56 ± 2.85/h vs 2.79 ± 0.61/h, P < 0.01). The comparison of sleep parameters among Child A, B and C cirrhotic patients revealed a significant reduction of REM sleep stage occurrence in individuals with severe liver disease (Child C patients) compared to Child A/B patients (polysomnography percentage of REM sleep stage of patients Child A: 16.1% ± 1.2%; Child B: 14.9% ± 1.2%; Child C: 8.6% ± 1.6%, P < 0.05). CONCLUSION: Cirrhosis was associated with shorter sleep time, reduced sleep efficiency, increased sleep latency, increased REM latency and reduced REM sleep. Additionally, disease severity influences sleep parameters. | Vinicius Vasconcelos Teodoro Mauricio Augusto Bragagnolo Júnior Ligia Mendona Lucchesi Daniel Cavignolli Marco Túlio de Mello Mario Kondo Sergio Tufik | 2013 | World Journal of Gastroenterology2013，19，22： | 1 |
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