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| 1 | Nanoparticles for targeted delivery of therapeutics and small interfering RNAs in hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC) is the 5th most common malignancy which is responsible for more than half million annual mortalities; also, it is the third leading cause of cancer related death. Unfavorablesystemic side-effects of chemotherapeutic agents and susceptibility to the degradation of small interfering RNAs(si RNAs), which can knock down a specific gene involved in the disease, have hampered their clinical application. So, it could be beneficial to develop an efficient carrier for the stabilization and specific delivery of drugs and si RNA to cells. Targeted nanoparticles have gained considerable attention as an efficient drug and gene delivery system, which is due to their capability in achieving the highest accumulation of cytotoxic agents in tumor tissue, modifiable drug pharmacokinetic- and bio-distribution, improved effectiveness of treatment, and limited sideeffects. Recent studies have shed more light on the advantages of novel drug loaded carrier systems vs free drugs. Most of the animal studies have reported improvement in treatment efficacy and survival rate using novel carrier systems. Targeted delivery may be achieved passively or actively. In passive targeting, no ligand as homing device is used, while targeting is achieved by incorporating the therapeutic agent into a macromolecule or nanoparticle that passively reaches the target organ. However, in active targeting, the therapeutic agent or carrier system is conjugated to a tissue or cell-specific receptor which is overexpressed in a special malignancy using a ligand called a homing device. This review covers a broad spectrum of targeted nanoparticles as therapeutic and nonviral si RNA delivery systems, which are developed for enhanced cellular uptake and targeted gene silencing in vitro and in vivo and their characteristics and opportunities for the clinical applications of drugs and therapeutic si RNA are discussed in this article. Asialoglycoprotein receptors, low-density lipoprotein, ganglioside GM1 cell surface ligand, epidermal growth factor receptor receptors, monoclonal antibodies, retinoic acid receptors, integrin receptors targeted by Arg-Gly-Asp peptide, folate, and transferrin receptors are the most widely studied cell surface receptors which are used for the site specific delivery of drugs and si RNA-based therapeutics in HCC and discussed in detail in this article. | Jaleh Varshosaz Maryam Farzan | 2015 | World Journal of Gastroenterology2015，21，42： | 10 |
| 2 | Nanostructured lipid carriers(NLC) : a potential delivery system for bioac- tive food molecules 显示文摘 | Tamjidi F Shahedi M Varshosaz J | 2013 | Innov Food Sci Emerg Technol2013，19，： | 1 |
| 3 | Pectin film coated pellets for colon-targeted delivery of budesonide: In-vitro/in-vivo evalua- tion in induced ulcerative colitis in rat显示文摘 | Varshosaz J Emami J Tavakoli N | 2012 | Iranian Joumal of Phar- maceutical Research : IJPR2012，11，3： | 1 |
| 4 | Promising dissolution enhancement effect of soluplus on crystallized celecoxib obtained through antisolvent precipitation and high pressure homogenization techniques 显示文摘 | Homayouni A Sadeghi F Varshosaz J | 2014 | Colloids SurfB Biointerfaces2014，122，： | 1 |
| 5 | Development and optimization of solid lipid nanoparticles of amikacin by central composite design显示文摘 | Varshosaz J GhaffariS Khoshayand MR | 2010 | J Liposome Res2010，20，2： | 1 |
| 6 | Synthesis and e- valuation of dextran-budesonide conjugates as colon specific pro- drugs for treatment of ulcerative colitis 显示文摘 | VARSHOSAZ J EMAMI J TAVAKOLI N | 2009 | Int J Pharm2009，365，12： | 1 |
| 7 | Effectiveness of budesonide-suceinate-dextran conjugate as a novel prodrug of budesonide against acetic acid-induced colitis in rats 显示文摘 | VARSHOSAZ J EMAMI J FASSIHI A | 2010 | Int J Colorectal Dis2010，25，10： | 1 |
| 8 | The effect of structural changes on swelling kinetics of polybasic/hydrophobic pH-sensitive hydrogels显示文摘 | Falamarzian M Varshosaz J | 1998 | Drug Dev Ind Pharm1998，24，： | 1 |
| 9 | Preparation of budesonide-dextran conjugates using glutarate spacer as a colon- targeted drug delivery system: In vitroain vivo evaluation in in- duced ulcerative colitis 显示文摘 | VARSHOSAZ J EMAMI J AHMADI F | 2011 | J Drug Target2011，19，2： | 1 |
| 10 | Effect of binder level and granulating liquid on phenylbutazone pellets prepared by extrusion-spheronization显示文摘 | Varshosaz J Kennedy RA Gipps EM | 1997 | Drug Dev Ind Pharm1997，23，7： | 1 |
| 11 | Use of hydrophilic natural gums in formulation of sustained-release matrix tablets of tramadol hydrochloride显示文摘 | Jaleh Varshosaz Naser Tavakoli Fatemeh Kheirolahi | 2006 | AAPS PharmSciTech2006，，1： | 1 |
| 12 | Formulation and in vitro characterization of ciprofloxacin floating and bioadhesive extended release tablets 显示文摘 | Varshosaz J Tavakoli N Roozbahani F | 2006 | Drug Dcliv2006，12，4： | 1 |
| 13 | Comparison of conventional radiography with cone beam computed tomography for detection of vertical root fractures:an in vitro study显示文摘 | Varshosaz M Tavakoli MA Mostafavi M | 2010 | J Oral Sci2010，52，4： | 1 |
| 14 | Effect of binderlevel and granulating liquid on phenylbutazone pellets prepared by extrusion-spheronization 显示文摘 | Varshosaz J Kennedy R A Gipps E M | 1997 | Drug Dev Ind Pharm1997，23，7： | 1 |
| 15 | Stability and antimicrobial effect of amikacin-loaded solid lipid nanoparticles 显示文摘 | Ghaffari S Varshosaz J Saadat A | 2010 | Int J Nanomedi2010，6，1： | 1 |
| 16 | The promise of chitosan microspheres in drug delivery systems显示文摘 | Varshosaz J | 2007 | Expert Opin Drug Deliv2007，4，3： | 1 |
| 17 | Comparison of con- ventional radiography with cone beam computed tomography for de- tection of vertical root fractures:An in vitro study显示文摘 | Varshosaz M Tavakoli MA Mostafavi M | 2010 | J Oral Sci2010，52，4： | 1 |
| 18 | Preparation of cefuroxime axetil nanoparticles by rapid expansion of supercritical fluid technology显示文摘 | J. Varshosaz F. Hassanzadeh M. Mahmoudzadeh A. Sadeghi | 2008 | Powder Technology2008，，1： | 1 |
| 19 | Preparation of budesonide-dextran conjugates using glutarate spacer as a colon-targeted drug delivery system: in vitro/in vivo evalua-tion in induced ulcerative colitis 显示文摘 | Varshosaz J Emami J Ahmadi F | 2011 | J Drug Targeting2011，19，2： | 1 |
| 20 | Cross-linked Poly(vinyl alcohol)Study of Swelling and Drug Release Behaviour Hydrogel显示文摘 | VARSHOSAZ J KOOPAIE N | 2002 | Iranian Polymer Journal2002，11，2： | 1 |
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