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| 1 | Asiaticoside, a trisaccaride triterpene induces biochemical and molecular variations in brain of mice with parkinsonism显示文摘Background:Parkinson’s disease characterized by oxidative stress and mitochondrial damage in the pars compacta of substantia nigra remains a challenge to manage with an added disadvantage of side effects of L-levo dopa,the standard drug used for therapy.Thus,an alternative approach of utilizing natural components would be beneficial in the management of the disease.The present study was aimed to investigate the potential role of asiaticoside(As),a trisaccaride triterpene against1–methyl 4–phenyl 1,2,3,6 tetrahydropyridine(MPTP)-induced neurotoxicity in experimental mice.Methods:Mice were divided into 4 groups:Group I received vehicle saline,group II was treated with 20 mg/kg of body weight of MPTP(2 doses with 2 h intervals),group III received MPTP along with 50 mg/kg body weight of As for the 21 consecutive days starting from the day of MPTP intoxication.Group IV received 50 mg/kg body weight of asiaticoside for the same period serving as drug control.Animals were sacrificed at the end of experimental period and the striatum and midbrain samples were analyzed for enzyme assays,transmission electron microscopic(TEM)analysis.Immunofluorescent assay was performed to study the expression of GFAP to detect astrocyte,which are activated due to neuronal damage.Imunohistochemical studies were carried out to quantify the expression of Bax and Bcl2,the molecular signatures that would provide clues of the extent of neurodegeneration.Results:The activities of enzymes were increased on As administration when compared with those of group II animals.Expressions of Bax and Bcl2 along with GFAP did show significant variations(p<0.05)on MPTP treatment when compared to control animals and the changes were found to be reversed significantly(p<0.05)after treatment with asiaticoside.TEM analysis also showed attenuated degenerative architecture on As administration.The mice which received As alone(drug control IV)did not show significant variation from that of the control mice.Conclusion:The observations suggest that asiaticoside may be efficacious in protecting neurons from the oxidative damage caused by the insult of MPTP. | Uvarajan Sampath Vanisree Arambakkam Janardhanam | 2013 | Translational Neurodegeneration2013，2，1： | 4 |
| 2 | Identification of four small m olecular mass proteins in the silk of Bombyx mori显示文摘 | Nirmala X Mita K Vanisree V | | 0，，05： | 1 |
| 3 | Ferulic acid, a phenolic phytochemical, inhibits UVB-induced matrix metalloproteinases in mouse skin via posttranslational mechanisms显示文摘 | Vanisree Staniforth Wen-Ching Huang Kandan Aravindaram Ning-Sun Yang | 2012 | The Journal of Nutritional Biochemistry2012，，5： | 1 |
| 4 | Immunomodulatory effects of phytocompounds characterized by in?vivo transgenic human GM-CSF promoter activity in skin tissues显示文摘 | Pei-Fen Su Vanisree Staniforth Chin-Jin Li Chien-Yu Wang Ming-Tsang Chiao Sheng-Yang Wang Lie-Fen Shyur Ning-Sun Yang | 2008 | Journal of Biomedical Science2008，，6： | 1 |
| 5 | Identification of four small molecular mass proteins in the silk of Bombyx mori显示文摘 | Nirmala X Mita K Vanisree V | 2001 | Insect Mol Biol2001，10，5： | 1 |
| 6 | In vitro evaluation of red and green lettuce (Lactuca sativa ) for functional food properties 显示文摘 | Vanisree M Mathieu N Ajay N | 2010 | Food Chemistry2010，118，11： | 1 |
| 7 | Status of lipid peroxidation and antioxidant enzymes in malignant (bronchogeniccarcinoma) and non- malignant pleural effusions显示文摘 | Vanisree AJ Shyamaladevi CS | 1999 | Indian J Cancer1999，36，2： | 1 |
| 8 | Identification of four small molecular mass proteins in the silk of Bombyx mori显示文摘 | NIRMALA X MITA K VANISREE V | 2001 | Insect Mol Biol2001，10，5： | 1 |
| 9 | Naringenin,a flavanone inhibits the proliferation of cerebrally implanted C6glioma cells in rats显示文摘 | Sabarinathan D Mahalakshmi P Vanisree AJ | 2011 | Chem Biol Interact2011，189，12： | 1 |
| 10 | Studies on the production of someimportant secondary metabolites from medicinal plants by plant tissuecultures 显示文摘 | Vanisree M Lee C Y Lo S F | 2004 | Botanical Bulletin of Academia Sinica2004，45，1： | 1 |
| 11 | Naringenin promote apoptosis in cerebrally implanted C6 glioma cells 显示文摘 | Sabarinathan D Mahalakshmi P Vanisree A J | 2010 | Mol Cell Biochem2010，435，12： | 1 |
| 12 | Impact of alkyl esters of caffeic and ferulic acids on tumor cell proliferation,cyclooxygenase enzyme,and lipid peroxidation显示文摘 | Jayaprakasam B Vanisree M Zhang Y | 2006 | J Agric Food Chem2006，54，15： | 1 |
| 13 | Studies on the production of some important secondary metabolites from medicinal plants by plant tissue cultures显示文摘 | Vanisree M Lee C Y Lo S F | 2004 | Bot Bull Acad Sin2004，45，1： | 1 |
| 14 | Studies on the production of some important secondary metabolites from medicinal plants by plant tissue cultures显示文摘 | VANISREE M LEE C Y LO S F | 2004 | Bot Bull Acad Sin2004，45，： | 1 |
| 15 | Curcumin Combats Against Cigarette Smoke and Ethanol-Induced Lipid Alterationsin Rat Lung and Liver显示文摘 | Vanisree A J Sudha N | 2006 | Molecular and Cellular Biochemistry2006，288，12： | 1 |
| 16 | In pact of alkyl esters of caffeic and ferulic acids on tumor cell proliferation, cyclooxygenase enzyme, and lipid peroxidation 显示文摘 | JAYAP RAKASAM B VANISREE M ZHANG Y | 2006 | J Agric Fobd Chem2006，54，15： | 1 |
| 17 | Naringenin, a flavanone alters the tumorigenic features of C6 glioma cells显示文摘 | Devan Sabarinathan Arambakkam Janardhanam Vanisree | 2011 | Biomedicine & Preventive Nutrition2011，，1： | 1 |
| 18 | In Vitro Evaluation of Red and Green Lettuce (Lactuca sativa) for Functional Food Properties显示文摘 | Vanisree Mulabagal Mathieu Ngouajio Ajay Nair | 2010 | Food Chemistry2010，118，： | 1 |
| 19 | Naringenin pro- mote apoptosis in cerebrally implanted C6 glioma cells 显示文摘 | Sabarinathan D Mahalakshmi P Vanisree A J | 2010 | Mol Cell Biochem2010，345，12： | 1 |
| 20 | Ursolic acid analogues: non-phenolic functional food components in Ja- maican raspberry fruits 显示文摘 | Camille S Bowen-Forbes Vanisree Mulabagal | 2009 | Food Chem2009，116，3： | 1 |
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