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| 1 | Melanoma of the rectum: A rare entity显示文摘A 41-year-old man presented with a 6-mo history of changed defecation and rectal bleeding. A 3-cm polypoid tumor of the lower rectum was found at rectosigmoidos- copy, which proved to be a leiomyosarcoma upon biopsy. Dissemination studies did not show any metastases. He was underwent to an abdomino-perineal resection (APR). Histopathology of the specimen showed a melanoma (S-100 stain positive). Two years after the resection, me- tastases in the abdomen and right lung were found. He died one and half years later. Primary anorectal melano- ma is a rare and very aggressive disorder. According to current data, one should always perform a S-100 stain when anorectal sarcoma is suspected. A positive S-100 stain suggests the tumour to be most likely a melanoma. Subsequently, thorough dissemination studies need to be performed. Depending on the outcome of the dissemina- tion studies, a surgical resection has to be performed. Nowadays, a sphincter-saving local excision combined with adjuvant loco-regional radiotherapy should be pre- ferred in case of small tumors. The same loco-regional control is achieved with less 'loss of function' compared to non-sphincter saving surgery. Only in the case of large and obstructing tumors an abdomino-perineal resection is the treatment of choice. | PM van Schaik MF Ernst HA Meijer K Bosscha | 2008 | World Journal of Gastroenterology2008，14，10： | 3 |
| 2 | Auto immune hepatitis显示文摘To provide an update of the latest trends in epidemiology, clinical course, diagnostics, complications and treatment of auto immune hepatitis(AIH). A search ofthe MEDLINE database was performed using the search terms: 'auto immune hepatitis', 'clinical presentation', 'symptoms', 'signs', 'diagnosis', 'auto antibodies', 'laboratory values', 'serology', 'histopathology', ' h i s t o l o g y ', ' g e n e t i c s ', 'HLA g e n e s ', 'non-HLA genes', 'environment', 'epidemiology', 'prevalence', 'incidence', 'demographics', 'complications', 'HCC', 'PBC', 'PSC', 'corticosteroid', 'therapy', 'treatment', 'alternative treatment'. English-language full-text articles and abstracts were considered. Articles included reviews, meta-analysis, prospective retrospective studies. No publication date restrictions were applied. AIH is an immune meditated progressive inflammatory liver disease that predominantly affects middle-aged females but may affect people of all ages. The clinical spectrum of AIH is wide, ranging from absent or mild symptoms to fulminant hepatic failure. The aetiology of AIH is still unknown, but is believed to occur as the consequence of an aberrant immune response towards an un-known trigger in a genetically susceptible host. In the absence of a gold standard, diagnosis is based on the combination of clinical, biochemical and histopathological criteria. Immunosuppressive treatment has been the cornerstone of treatment since the earliest description of the disease in 1950 by Waldenstr?m. Such treatment is often successful at inducing remission and generally leads to normal life expectancy. Nevertheless, there remain significant areas of unmet aetiological a clinical needs including fundamental insight in disease pathogenesis, optimal therapy, duration of treatment and treatment alternatives in those patients unresponsive to standard treatment regimens. | nicole mf van gerven ynto s de boer chris jj mulder carin mj van nieuwkerk gerd bouma | 2016 | World Journal of Gastroenterology2016，22，19： | 3 |
| 3 | The ins and outs of FOXO shuttling:mechanisms of FOXO translocation and transcriptional regulation显示文摘 | van Der Heide LP Hoekman MF Smidt MP | 2004 | Biochem J2004，380，： | 1 |
| 4 | Bone-alkaline phosphatase as indicator of bone formation显示文摘 | Van Straalen JP Sanders R Prummel MF | 1991 | Clin Chim Acta1991，201，12： | 1 |
| 5 | Reconstitution of the vascular wall in vitro: A novel model to study interactions between endothelial and smooth muscle cells显示文摘 | van Bull - Wortelboer MF Brinkman HJM Dingemans KP | 1986 | Exp Cell Res1986，162，： | 1 |
| 6 | Iodine-induced thyroid inhibition and cell necrosis:two consequences of the same free-radical mediated mechanism显示文摘 | DENEF JF MANY MC VAN DEN HOVE MF | 1996 | Mol Cel Endocrinology1996，121，1： | 1 |
| 7 | Glutamine and the preservation of gut integrity显示文摘 | Van der Hulst RR Van Kreel BK Von Meyenfeldt MF | 1993 | Lancet1993，341，8857： | 1 |
| 8 | The early history of tubulation in nerve repair显示文摘 | IJpma FF Van De Graaf RC Meek MF | | 0，，05： | 1 |
| 9 | Gut permeability,intestinal morphology,and nutrition depletion显示文摘 | Von Meyenfeldt MF Van Kreel BK | 1998 | Nutrition1998，14，2： | 1 |
| 10 | A meta-analysis ofelectroconvulsive therapy efficacy in depression 显示文摘 | Kho KH van Vreeswijk MF Simpson S | 2003 | J ECT2003，19，3： | 1 |
| 11 | The use of poly-L- lactic acid in lumbar interbody cages: design and biomechanical evaluation in vitro显示文摘 | van Dijk M Smit TH Arnoe MF | 2003 | Fur Spine J2003，12，1： | 1 |
| 12 | Correlation of reversion-inducing eysteine-rich protein with kazal motifs (RECK) and extracellular matrix metalloproteinase inducer (EMMPRIN), with MMP-2, MMP-9, and survival in coloreetal cancer 显示文摘 | Van der Japt MF Sweep FC Waas ET | 2006 | Cancer Lett2006，237，2： | 1 |
| 13 | Variation of consumer contact with household products:a preliminary investigation显示文摘 | Weegels MF van Veen MP | 2001 | Risk Analysis2001，21，： | 1 |
| 14 | Identification of a new human eoronavirus 显示文摘 | VAN DER HOEK L PYRC K JEBBINK MF | 2004 | Nature Med2004，10，4： | 1 |
| 15 | P0sterior Urethral Valves in Three Siblings:A CaseReport and Review of theLiterature显示文摘 | schreuder MF~Van der Horst HJ Bokonkam PA) | 2008 | Birth Defects Research2008，82，4： | 1 |
| 16 | A mutation in human keratin K6b produces a phenocopy of the K17 disorder pachyonychia congenita type 2显示文摘 | Smith FJ Jonkman MF van Goor H | 1998 | Hum Mol Genet1998，7，7： | 1 |
| 17 | Developing quality indicators for general practice care for vulnerable elders transfer from US to the Netherlands显示文摘 | Van der Ploeg E Depla MF Shekelle P | 2008 | Qual Saf Health Care2008，17，4： | 1 |
| 18 | Vaccination with live type 4 adenovirus: evaluation of antibody response and protective efficacy显示文摘 | van der Veen J Abarbanel MF Oei KG | 1969 | Antonie van Leeuwenhoek1969，35，2： | 1 |
| 19 | The comparative effects of remifentanil or magnesium sulfate versus placebo on attenuating the hemodynamic responses after electreconvulsive therapy 显示文摘 | van Zijl DH Gordon PC James MF | 2005 | Anesth Analg2005，101，6： | 1 |
| 20 | Vaccination with live type 4 adenovirus: evaluation of antibody response and protective efficacy显示文摘 | van der Veen J Abarbanel MF Oei KG | 1968 | J Hyg (Lond)1968，66，4： | 1 |
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