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| 1 | Colonoscopic yield of colorectal neoplasia in daily clinical practice显示文摘AIM:To assess the prevalence and location of ad-vanced neoplasia in patients undergoing colonoscopy,and to compare the yield per indication.METHODS:In a multicenter colonoscopy survey (n = 18 hospitals) in the Amsterdam area (Northern Holland),data of all colonoscopies performed during a three month period in 2005 were analyzed. The location and the histological features of all colonic neoplasia were recorded. The prevalence and the distribution ofadvanced colorectal neoplasia and differences in yield between indication clusters were evaluated. Advanced neoplasm was defi ned as adenoma > 10 mm in size,with > 25% villous features or with high-grade dyspla-sia or cancer.RESULTS:A total of 4623 eligible patients underwent a total colonoscopy. The prevalence of advanced neo-plasia was 13%,with 281 (6%) adenocarcinomas and 342 (7%) advanced adenomas. Sixty-seven percent and 33% of advanced neoplasia were located in the distal and proximal colon,respectively. Of all patients with right-sided advanced neoplasia (n = 228),51% had a normal distal colon,whereas 27% had a syn-chronous distal adenoma. Ten percent of all colono-scopies were performed in asymptomatic patients,7% of whom had advanced neoplasia. In the respective procedure indication clusters,the prevalence of right-sided advanced neoplasia ranged from 11%-57%. CONCLUSION:One out of every 7-8 colonoscopies yielded an advanced colorectal neoplasm. Colonoscopy is warranted for the evaluation of both symptomatic and asymptomatic patients. | Jochim S Terhaar sive Droste Mike E Craanen Rene WM van der Hulst Joep F Bartelsman Dick P Bezemer Kim R Cappendijk Gerrit A Meijer Linde M Morsink Pleun Snel Hans ARE Tuynman Roy LJ van Wanrooy Eric IC Wesdorp Chris JJ Mulder | 2009 | World Journal of Gastroenterology2009，15，9： | 6 |
| 2 | β-Arrestin 1 and 2 and G protein-coupled receptor kinase 2 expression in pituitary adenomas:role in the regulation of response to somatostatin analogue treatment in patients with acromegaly显示文摘Recent in vitro studies highlighted G protein-coupled receptor kinase(GRK)2 andβ-arrestins as important players in driving somatostatin receptor(SSTR)desensitization and trafficking.Our aim was to characterize GRK2 andβ-arrestins expression in different pituitary adenomas and to investigate their potential role in the response to somatostatin analog(SSA)treatment in GHsecreting adenomas(GHomas).We evaluated mRNA expression of multiple SSTRs,GRK2,β-arrestin 1,andβ-arrestin 2 in 41pituitary adenomas(31 GHomas,6 nonfunctioning[NFPAs],and 4 prolactinomas[PRLomas]).Within the GHomas group,mRNA data were correlated with the in vivo response to an acute octreotide test and with the GH-lowering effect of SSA in cultured primary cells.β-Arrestin 1 expression was low in all 3 adenoma histotypes.However,its expression was significantly lower in GHomas | Gatto F Feelders R van der Pas R Kros JM Dogan F van Koetsveld PM van der Lelij AJ Neggers SJ Minuto F de Herder W Lamberts SW Ferone D Hofland LJ | 2013 | 中国神经肿瘤杂志2013，11，4： | 2 |
| 3 | Diffusion weighted magnetic resonance imaging in acute 显示文摘 | Van Everdingen K J Van der ground T Kappelle LJ | 2007 | Stroke2007，29，： | 1 |
| 4 | The role of membrane fatty-acid transporters in regulating skeletal muscle substrate use during exercise显示文摘 | Pelsers MM Stellingzoerff T van Loon LJ | 2008 | Sports Med2008，38，5： | 1 |
| 5 | The Janus face of glial-derived S100B :beneficial and detrimental functions in the brain 显示文摘 | Van Eldik LJ Wainwright MS | 2003 | Re- stor Neurol Neurosci2003，21，34： | 1 |
| 6 | A gene-expression signature as a predictor of survival in breast cancer显示文摘 | van de Vijver MJ He YD van't Veer LJ | 2002 | N Engl j Med2002，347，25： | 1 |
| 7 | Selective serotonin-reuptake inhibitors and risk of persistent pulmonary hypertension of the newborn显示文摘 | Chambers CD Hernandez-Diaz S Van Marter LJ | | 0，，06： | 1 |
| 8 | The DD genotype of the ACE gene polymorphism is associated with progression of diabetic nephropathy to end stage renal failure in IDDM显示文摘 | Vleming LJ van der Pijl JW Lemkes HH | 1999 | Clin Nephrol1999，51，： | 1 |
| 9 | The p38 MAP kinase family as regulators of proinflammatory cytokine production in degenerative diseases of the CNS显示文摘 | Bachstetter AD Van Eldik LJ | 2010 | Aging Dis2010，1，3： | 1 |
| 10 | Neonatal outcome after caesarean birth for fetal distress and/or meconium staining in a South African rural setting显示文摘 | Van Bogaert LJ Misra A | 2008 | J Obstet Gynaecol2008，28，1： | 1 |
| 11 | Role of Fas-mediated cell death in the regulation of immune responses显示文摘 | Van Parijis LJ and Abbas AK | 1996 | Curt Opin Inmmunol1996，8，： | 1 |
| 12 | A gene-expression signature as a predictor of survival in breast cancer 显示文摘 | van de Vijver MJ He YD van't Veer LJ Dai H Hart AA Voskuil DW | 2002 | N Engl J Med2002，347，25： | 1 |
| 13 | Soluble adhesion molecules reflect endothelial cell activation in ischaemic stroke and in carotid atherosclerosis显示文摘 | Frijns CJM Kappelle LJ Van Gijn J | 1997 | Stroke1997，28，： | 1 |
| 14 | Influence of prolonged endurance cycling and recovery diet on intramuscular triglyceride content in trained males显示文摘 | Van Loon LJ Schrauwen-Hinderling VB Koopman R | 2003 | Am J Physiol Endocrinol Metab2003，285，4： | 1 |
| 15 | MRA flow quantification in patients with a symptomatic internal carotid artery occlusion显示文摘 | van Everdingen KJ Klijn CJ Kappelle LJ | 1997 | Stroke1997，28，8： | 1 |
| 16 | Nonsteroidal antiinflammatory drugs and the risk of Alzheimer′s disease显示文摘 | in t′Veld BA Ruitenberg A Hofman A Launer LJ van Duijn CM Stijnen T | 2001 | N Engl J Med2001，345，21： | 1 |
| 17 | Stretch-induced paracrine hypertrophic stimuli increase TGF-beta1 expression in cardiomyocytes显示文摘 | van Wamel AJ Ruwhof C van der Valk-Kokshoom LJ | 2002 | Mol Cell Biochem2002，236，12： | 1 |
| 18 | N-acetylcysteine and hemodialysis treatment of a severe case of methyl ethyl ketone peroxide intoxication显示文摘 | van Enckevort CC Touw DJ Vleming LJ | 2008 | Clin Toxicol2008，46，： | 1 |
| 19 | MFG-E8 regulates microglial phagocytosis of apoptotic neurons显示文摘 | Fuller AD Van Eidik LJ | 2008 | J Neuroinnune Pharmacol2008，3，4： | 1 |
| 20 | Migraine is associated with an increased Risk of deep white matter lesions,subclinical posterior circulation infarcts and brain iron accumulation:the population-based显示文摘 | Krinit MC van Bnchem MA launer LJ | 2010 | MRI CAMERA Cephalalgia2010，30，： | 1 |
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