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| 1 | 选择性5-羟色胺再吸收抑制剂与新生儿持续性肺动脉高压患病风险显示文摘Background: Persistent pulmonary hypertension of the newborn(PPHN) is associated with substantial infant mortality and morbidity. A previous cohort study suggested a possible association between maternal use of the selective serotonin- reuptake inhibitor(SSRI) fluoxetine late in the third trimester of pregnancy and the risk of PPHN in the infant. We performed a case- control study to assess whether PPHN is associated with exposure to SSRIs during late pregnancy. Methods: Between 1998 and 2003, we enrolled 377 women whose infants had PPHN and 836 matched control women and their infants. Maternal interviews were conducted by nurses, who were blinded to the study hypothesis, regarding medication use in pregnancy and potential confounders, including demographic variables and health history. Results: Fourteen infants with PPHN had been exposed to an SSRI after the completion of the 20th week of gestation, as compared with six control infants(adjusted odds ratio, 6.1; 95 percent confidence interval, 2.2 to 16.8). In contrast, neither the use of SSRIs before the 20th week of gestation nor the use of non- SSRI antidepressant drugs at any time during pregnancy was associated with an increased risk of PPHN. Conclusions: These data support an association between the maternal use of SSRIs in late pregnancy and PPHN in the offspring; further study of this association is warranted. These findings should be taken into account in decisions as to whether to continue the use of SSRIs during pregnancy. | Chambers C. D. Hernandez-Diaz S. Van Marter L.J. 任付先(译) 马超(校) | 2006 | 世界核心医学期刊文摘(心脏病学分册)2006，2，6： | 5 |
| 2 | Selective serotonin-reuptake inhibitors and risk of persistent pulmonary hypertension of the newborn显示文摘 | Chambers CD Hernandez-Diaz S Van Marter LJ | | 0，，06： | 1 |
| 3 | Endotoxin -directed innate immunity in tracheal aspirates of mechanically ventilated human neonates显示文摘 | Nathe KE Parad R Van Marter LJ | 2009 | Pediatr Res2009，66，2： | 1 |
| 4 | Fetal growth restriction and chronic lung disease among infants born before the 28th week of gestation显示文摘 | Bose C Van Marter L J Laughon M | 2009 | Pediatrics2009，124，3： | 1 |
| 5 | Fetal growth restriction and chronic lung disease among infants born before the 28th week of gestati显示文摘 | Bose C Van Marter LJ Laughon M | 2009 | Pediatrics2009，124，3： | 1 |
| 6 | Do clinical markers of barotrauma and oxygen toxicity explain interhospital variation in rates of chronic lung disease?The Neonatology Committee for the Developmental Network显示文摘 | Van Marter LJ Allred EN Pagano M | 2000 | Pediatrics2000，105，6： | 1 |
| 7 | Summary proceedings from the bronchopulmonary dysplasia group显示文摘 | Walsh MC Szefler S Davis J Allen M Van Marter L Abman S | 2006 | Pediatrics2006，117，3： | 1 |
| 8 | Induction of apoptosis by Apo2- ligand , a new member of the tumor necrosis factor cytokine family显示文摘 | PITTIR M MARTERS A RUPPERT S | 1996 | J Biol Chem1996，271，12： | 1 |
| 9 | Chorioamnionitis,mechanical ventilation,and post natal sepsis as modulators of chronic lung disease in preterm infants显示文摘 | Van Marter LJ Damonn O Allred EN | 2002 | J Pediatr2002，140，： | 1 |
| 10 | Improved oxygenation in a randomized trial of inhaled nitric oxide for persistent puhnonary hypertension of the newbom显示文摘 | Wessel DL Adatia I Van Marter LJ | 1997 | Pediatrics1997，100，5： | 1 |
| 11 | Chronic lung disease and developmental delay at 2 years of age in children born before 28 weeks' gestation显示文摘 | Laughon M O'Shea MT Allred EN Bose C Kuban K Van Marter LJ | 2009 | Pediatrics2009，124，2： | 1 |
| 12 | Fetal growth restriction and chronic lung disease among infants born before the 28th week of gestation显示文摘 | Bose C Van Marter LJ Laughon M | 2009 | Pediatrics2009，124，3： | 1 |
| 13 | Risk factors for persistent pulmonary hypertension of the newborn 显示文摘 | Diaz SH Van Marter LJ Werler MM | 2007 | Pediatrics2007，120，2： | 1 |
| 14 | Selective serotonin-reuptake inhibitors and risk of persistent pulmonary hypertension of the newborn 显示文摘 | Christina DC Diaz SH Van Marter LJ | 2006 | N Engl J Med2006，354，6： | 1 |
| 15 | Antecedents of clinically significant pulmonary hemorrhagre among newborn infants显示文摘 | Berger T M Allred E N Van Marter L J | 2000 | J Perinatol2000，20，5： | 1 |
| 16 | Strategies for preventing bronchopulmonary dysplasia 显示文摘 | van Marter LJ | 2005 | Curr Opin Pediatr2005，17，2： | 1 |
| 17 | Epidemiology of bronchopulmonary dysplasia显示文摘 | Van Marter LJ | 2009 | Semin Fetal Neonatal Med2009，14，6： | 1 |
| 18 | Do clinical markers of barotraumas and oxygen toxicity explain interhospital variation rates of chronic lung disease?显示文摘 | Van Marter LJ Allred EN Pagano M | 2000 | Pediatrics2000，105，： | 1 |
| 19 | Antenatal glucocorticoids increase early total thyroxine levels in premature infants 显示文摘 | Martin CR LJ Van Marter EN Allred | 2005 | Biol Neonate2005，87，4： | 1 |
| 20 | Do clinical markers of barotrauma and oxygen toxicity explain interhospital variation in rates of chronic lung disease? The Neonatology Committee for the Developmental Network显示文摘 | Van Marter LJ Allred EN Pagano M | 2000 | Pediatrics2000，105，6： | 1 |
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