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| 1 | The 5-HT2c receptor gene Cys23Ser polymorphism influences the intravaginal ejaculation latency time in Dutch Caucasian men with lifelong premature ejaculation显示文摘有终生的早泄(LPE ) 的人的坚持的短 intravaginal 射精潜伏时间(IELT ) 与 5-hydroxytryptamine (HT ) 有关是 2C 受体工作,这被要求了。这研究的目的是与 LPE 在人调查 Cys23Ser 5-HT 2C 受体基因多型性和 IELT 的持续时间的关系。因此,未来的研究与 LPE 在 64 个荷兰的白种人人被进行。基线 IELT 被秒表在一个 1 月的时期上在性交期间估计。所有人是为 Cys23Ser 5-HT 2C 受体基因多型性的 genotyped。Cys 的等位基因频率和 5-HT 2C 受体基因多型性的重量的单位变体是坚定的。在 Cys/Cys 和重量的单位 / 重量的单位遗传型和在有 LPE 的人的 IELT 的自然对数之间的协会被调查。作为结果,几何吝啬、中部、自然的吝啬的 IELT 是 25.2, 27.0, 33.9 s 分别地。所有人, 20.0% , 10.8% , 23.1% 和 41.5% 在 10 以内射精,在阴道穿入以后的 10-20, 20-30 和 30-60 s。64 个人,为 5-HT 2C 受体基因的 Cys23Ser 多型性的 Cys/Cys 和重量的单位 / 重量的单位遗传型频率分别地是 81% 和 19% 。wildtypes (Cys/Cys ) 的几何吝啬的 IELT 显著地更低(22.6 s;95% CI 18.3-27.8 s ) 比在男同型结合的异种(重量的单位 / 重量的单位)(40.4 s;95% CI 20.3-80.4 s )(P = 0.03 ) 。Cys23Ser 5-HT 2C 受体基因多型性与 LPE 在人与 IELT 被联系,这被结束。有 Cys/Cys 遗传型的人与重量的单位 / 重量的单位遗传型比人有更短的 IELT。 | Paddy KC Janssen Ron van Schaik Berend Olivier Marcel D Waldinger | 2014 | Asian Journal of Andrology2014，16，4： | 3 |
| 2 | Late side eftects ot short-course preoperative radiotherapy combined with total mesorectal excision for rectal cancer: increased bowel dysfunction in irradiated patients-a Dutch colorectal cancer group study 显示文摘 | Pceters KC van de Velde C J Leer JW | 2005 | J Clin Oncol2005，23，25： | 1 |
| 3 | NAAG peptidase inhibitor reduces cellular damage in a model of TBI with secondary hypoxia 显示文摘 | Feng JF Gurkoff GG Van KC | 2012 | Brain Res2012，1469，8： | 1 |
| 4 | Adenoma size and number are predictive of adenoma recurrence: implications for surveillance colonoscopy 显示文摘 | Noshir ~ani KC van Stolk RU Rybicki LA | 2000 | Gastrointest Endosc2000，51，41： | 1 |
| 5 | Spontaneous re mission in congenital leukemia is not related to (mosaic) trisomy 21 : case presentation and literature review 显示文摘 | Van den Berg H Hopman AH Kraakman KC | 2004 | Pediatr Hematoloncol2004，21，2： | 1 |
| 6 | VDR and SRDSA2 polymorphisms combine to increase risk for prostate cancer in both non-Hispanic White and Hispanic White men显示文摘 | Torkko KC van Bokhoven A Mai P | 2008 | Clin Cancer ges2008，14，10： | 1 |
| 7 | Toll-like ceptors in rheumatic diseases:are we paying a high price for our defense against bugs显示文摘 | Santegoets KC van Bon L van den Berg WB | | 0，，23： | 1 |
| 8 | Late side effects of short course preoperative radiotherapy combined with total mesoreetal excision for rectal cancer: increased bowel dysfunction in irradiated patients-a Dutch eolorectal cancer group study显示文摘 | Peeters KC van de Velde C J Leer JW | 2005 | J Clin Oncol2005，23，25： | 1 |
| 9 | Effects of acetate,propionate,and butyrate on the thermophilic anaerobic degradation of propionate by methanogenic sludge and defined cultures显示文摘 | Van Lier JB Grolle KC Frijters CT | | 0，，04： | 1 |
| 10 | Ademoma size and number are predictive of adenoma recurrence:Implications for surveillance colonoscopy显示文摘 | Noshirwani KC van Stolk RU Rybicki LA | 2000 | Gastrointest Endosc2000，51，： | 1 |
| 11 | The IL-9 receptor gene (IL9R):genomic structure,chromosomal localization in the pseudoautosomal region of the long arm of the sex chromosomes,and identification of IL9R pseudogenes at 9qter,10pter,16pter,and 18pter显示文摘 | Kermouni A Van Roost E Arden KC | 1995 | Genomics1995，29，2： | 1 |
| 12 | The inhibitory re ceptor FcγRⅡ reduces joint inflammation and destruction in experimental immune complex-mediated arthritides not only by inhibition of FcγRⅠ/Ⅲ but also by efficient clearance and endocytosis of immune complexes显示文摘 | van Lent P Nabbe KC Boross P | 2003 | Am J Pathol2003，163，： | 1 |
| 13 | NAAG peptidase inhibitor increases dialysate NAAG and reduces glutamate, aspartate and GABA levels in the dorsal hippocampus following fluid percussion injury in the rat 显示文摘 | Zhong C Zhao X Van KC | 2006 | J Neurochem2006，97，4： | 1 |
| 14 | Behavior problems in relation to sustained selective attention skills of moderately preterm children 显示文摘 | Bul KC van Baar AL | 2012 | Journal of developmental and physical disabilities2012，24，2： | 1 |
| 15 | Pitx3 is required for motor activity and for survival of a subset of midbrain dopaminergic neurons显示文摘 | Luk KC Ste-Marie L | 2003 | Development2003，130，11： | 1 |
| 16 | Predic- tive value of depressive symptoms and B - type natriuretic peptide for New - onset heart failure and mortality显示文摘 | Van den Broek KC Defilippi CR Christenson RH | 2011 | Am J Cardiol2011，107，5： | 1 |
| 17 | NAAG peptidase inhibitor increases dialysate NAAG and reduces glutamate, aspartate and GABA levels in the dorsal hippocampus following fluid percussion injury in the rat 显示文摘 | Zhong C Zhao X Van KC | 2006 | J Neurochem2006，97，4： | 1 |
| 18 | Protective and therapeutic role for alphaB-crystallln in autoimmune demyelination 显示文摘 | Ousman SS Tomooka BH van Noort JM Wawrousek EF O'Connor KC Hailer DA | 2007 | Nature2007，448，7152： | 1 |
| 19 | A population pharmacokinetic model of gabapentin developed in nonparametric adaptive grid and nonlinear mixed effec显示文摘 | Carlsson KC Van De Schootbrugge M Eriksen HO | 2009 | Ther Drug Monit2009，31，1： | 1 |
| 20 | Further factors for the esti- mation of mean glandular dose using the United Kingdom, European and IAEA breast dosimetry protocols显示文摘 | Dance DR Young KC Van Eegen RE | 2009 | Phys Med Biol2009，54，14： | 1 |
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