|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Cyclooxygenase-2 polymorphisms and the risk of esophageal adeno-or squamous cell carcinoma显示文摘AIM:To determine whether-1195 A→G and/or-765 G→C polymorphisms in Cyclooxygenase-2(COX-2 ) may have a risk modifying effect on the development of esophageal carcinoma in a Dutch Caucasian population.METHODS:Two study groups were recruited, 252 patients with esophageal carcinoma and 240 healthy controls, matched for race, age, gender and recruiting area.DNA was isolated from whole blood and used for genotyping.PCR products were digested with restriction enzymes and products were analyzed by agarose gel electrophoresis.Odds ratios(OR) and 95% confldence intervals(CI) were estimated.RESULTS:The distribution of the-1195 A→G polymorphism was signif icantly different in esophageal cancer patients compared to controls.The-1195 GG genotype resulted in a higher risk of developing esophageal adenocarcinoma(OR = 3.85, 95% CI:1.45-10.3) compared with the-1195 AA genotype as a reference.The-765 G→C genotype distribution was not different between the two groups.The GG/ GG haplotype was present more often in esophageal adenocarcinoma patients than in controls(OR = 3.45, 95% CI:1.24-9.58;with AG/AG as a reference).The same trends were observed in patients with squamous cell carcinomas, however, the results did not reach statistical signif icance.CONCLUSION:Presence of the COX-2-1195 GG genotype and of the GG/GG haplotype may result in a higher risk of developing esophageal carcinoma. | Jón O Kristinsson Paul van Westerveld Rene HM te Morsche Hennie MJ Roelofs T Wobbes Ben JM Witteman Adriaan CITL Tan Martijn GH van Oijen Jan BMJ Jansen Wilbert HM Peters | 2009 | World Journal of Gastroenterology2009，15，28： | 11 |
| 2 | COX-2 polymorphisms-765G→C and-1195A→G and colorectal cancer risk显示文摘AIM:To determine the possible modulating effect of the COX-2 polymorphisms,-765G→C and-1195A→G, on the risk of colorectal cancer(CRC)in a Dutch population. METHODS:This case-control study includes 326 patients with CRC and 369 age-and gender-matched controls.Genotypes of the COX-2 polymorphisms -765G→C and-1195A→G were determined by polymerase chain reaction-based restriction fragment length polymorphism.COX-2 genotypes and haplotypes were analyzed and odds ratios with 95%confi- dence intervals were estimated by logistic regression. RESULTS:The-765GG genotype was associated with an increased risk of developing CRC(OR,1.45; 95%CI,1.03-2.04).No significant difference was observed in the genotype distribution of the-1195A→ G polymorphism between patients and controls.The GG/AC haplotype was present significantly less often in patients than in controls(OR 0.44;95%CI,0.22-0.85). When the AC,AG and GG haplotypes were investigated separately,the AC haplotype showed a tendency to be less frequent in patients than in controls(OR(AG/AC)0.78; 95%CI,0.57-1.06). CONCLUSION:The-765GG genotype is associatedwith an increased risk of developing CRC and the GG/ AC haplotype seems to protect against CRC.These findings suggest a modulating role for the COX-2 polymorphisms-765G→C and-1195A→G in the development of CRC in a Dutch population. | Juliёt H Hoff Rene HM te Morsche Hennie MJ Roelofs Elise MJ van der Logt Fokko M Nagengast Wilbert HM Peters | 2009 | World Journal of Gastroenterology2009，15，36： | 6 |
| 3 | Assessment of oxidative stress in chronic pancreatitis patients显示文摘AIM: To assess the levels of antioxidant capacity and oxidative damage in blood of chronic pancreatitis (CP) patients in comparison with those in healthy control sub- jects, by using several different analytical techniques. METHODS: Thirty-five CP patients and 35 healthy con- trol subjects were investigated prospectively with re- spect to plasma levels of thiols, ferric reducing ability of plasma (FRAP, i.e. antioxidant capacity), levels of protein carbonyls and thiobarbituric acid reactive substances (TBARS). Additionally, we evaluated the production of reactive oxygen species (ROS) in whole blood. RESULTS: The antioxidative thiols including cysteine, cysteinylglycine and glutathione were significantly lower in CP patients. In addition, the non-enzymatic antioxi- dant capacity was significantly lower in CP patients, which correlated with the amount of oxidative protein (protein carbonyls) and the extent of lipid damage (TBARS), both were significantly higher in CP patients. The ROS production in whole blood after stimulation with phorbol 12-myritate 13-acetaat, demonstrated a strong tendency to produce more ROS in CP patients. CONCLUSION: Oxidative stress may contribute to the pathogenesis of chronic pancreatitis by decreasing anti- oxidant capacity and increasing oxidative damage in CP patients may be a rationale for intervention with antioxi- dant therapy. | Mariette Verlaan Hennie MJ Roelofs Annie van Schaik Geert JA Wanten Jan BMJ Jansen Wilbert HM Peters Joost PH Drenth | 2006 | World Journal of Gastroenterology2006，12，35： | 3 |
| 4 | Reversal of in vitro cellular MRPI and MRP2 mediated vincristine resistance by the flavonoid myricetin 显示文摘 | VAN ZANDEN JJ DE MUL A WORTELBOER HM | 2005 | Biochem Pharmacol2005，69，11： | 1 |
| 5 | Resemblance of osteophytes in experimental osteoarthritts to transforming growth factor beta-induced osteophytes:Limited role of bone morphogenetic protein in early osteoarthritic osteophyte formation显示文摘 | Blaney Davidson EN Vitters EL van Beuningen HM | 2007 | Arthritis Rheum2007，56，12： | 1 |
| 6 | Mechanisms of synergism between cisplatin and gemcitabine in ovarian abd non - small - cell lung cancer lines显示文摘 | Van Moorsel CJ Pinedo HM Veerman G | 1999 | Br J Cancer1999，80，7： | 1 |
| 7 | Comparative analysis of risk factors for pathological fracture with femoral metastases显示文摘 | Van Der Linden YM Dijkstra PD Kroon HM | 2004 | J Bone Joint Surg Br2004，86，： | 1 |
| 8 | Reverse structural and gap-junctional after prolonged atrial fibrillation in the goat显示文摘 | Ausma J van der Velden HM Lenders MH | 2003 | Circulation2003，107，15： | 1 |
| 9 | Strong decrease of high sensitivity C- reactive protein with high-dose atorvastation in patients with type 2 diabetes mellitus显示文摘 | Van de Ree MA Huisman MV Princen HM | 2003 | Atheroscler2003，116，1： | 1 |
| 10 | Gemcitabine: future prospects of single-agent and combination studies显示文摘 | Van Moorsel CJ Peters GJ Pinedo HM | 1997 | Oncologist1997，2，3： | 1 |
| 11 | Anterior chamber i- ris-fixated phakic intraocular lens for anisometropic amblyopia 显示文摘 | Saxena R van Minderhout HM Luyten GP | 2003 | J Cataract Refract Surg2003，29，4： | 1 |
| 12 | Mechanisms of symergism between and gemcitabine in ovarian and nonsmall lung cancer显示文摘 | Van Moorsec M Pinedo HM Veernan C | 1999 | Brj Cancer1999，80，7： | 1 |
| 13 | Treatmentof relapsed and refractory multiple myeloma in the era of novel a- gents显示文摘 | van de Donk NW Lokhorst HM Dimopoulos M | 2011 | Cancer Treat Rev2011，37，4： | 1 |
| 14 | Gene expression profile in the endometrium on the day of oocyte retrieval after ovarian stimulation with low-dose hCG in the follicular phase 显示文摘 | Blockeel C1 Van Vaerenbergh I Fatemi HM | 2011 | Mol Hum Reprod2011，17，1： | 1 |
| 15 | Impaired emotion recognition in music in Parkinson,s disease显示文摘 | van Tricht MJ Smeding HM Speelman JD | 2010 | Brain Cogn2010，74，1： | 1 |
| 16 | Paired measurements of quantitative hepatitis B virus DNA in saliva and serum of chronic hepatitis B patients:implications for saliva as infection agent显示文摘 | Van der Eijk AA Niesters HG Gotz HM | 2004 | J Clin Virol2004，29，2： | 1 |
| 17 | Clinica outcome of Crohn's disease according to the Vienna classification:disease location is a useful predictor of disease course显示文摘 | Oostenbrug LE van Dullenmen HM te Meerman GJ | 2006 | Eur J Gastroenterol Hepatol2006，18，3： | 1 |
| 18 | Resemblance of osteophytes in experimental osteoarthritis to transforming growth factor beta-induced osteophytes:limited role of bone morphogenetic protein in early osteoarthritic osteophyte formation显示文摘 | Blaney Davidson EN Vitters EL van Beuningen HM | | 0，，12： | 1 |
| 19 | Students' andteachers'perceptions of clinical assessment program:A qualitative study in a PBL curriculum显示文摘 | A l Kadri HM Al-Moamary M S van der Vleuten C | | 0，，02： | 1 |
| 20 | Antennal sensilla of two parasitoid wasps:a comparative scanning electron microscopy study显示文摘 | Bleeker MAK Smid HM van Aelst AC van Loon JJA Vet LEM | | 0，，05： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员